Filtered By:
Cancer: Gastric (Stomach) Cancer
This page shows you your search results in order of date. This is page number 20.
Order by Relevance | Date
Total 20058 results found since Jan 2013.
LDHA and LDHB overexpression promoted the Warburg effect in malignantly transformed GES-1 cells induced by N-nitroso compounds
Food Chem Toxicol. 2023 Aug 28:114007. doi: 10.1016/j.fct.2023.114007. Online ahead of print.ABSTRACTN-nitroso compounds (NOCs) exposure is a major risk factor for the development of gastric cancer. However, the carcinogenic mechanisms by which NOCs induce gastric and other cancers, especially the NOCs-induced Warburg effect, have not been comprehensively studied. Lactate dehydrogenase (LDH), which has two subunits (LDHA and LDHB), plays an important role in the Warburg effect of tumor cells. Therefore, we hypothesized that LDHA and LDHB could promote Warburg effect in malignant transformed GES-1 cells induced by Nmethyl-N...
Source: Food and Chemical Toxicology - August 30, 2023 Category: Food Science Authors: Xing Liu Xihuan Zou Yueyue Zhou Ruobing Chen Yuting Peng Man Qu Source Type: research
Synthesis, docking studies and evaluation of chalcones as anti-Helicobacter pylori and antitumoral agents
In this study, we synthesized and characterized a series of 14 chalcones and evaluated their anti-H. pylori, NO inhibition (in vitro and in silico), and AGS cells cytotoxic effects. The compounds 3b and 3h showed MIC of 8 µg/mL. We observed structure-activity relationships, mainly related to the influence of methoxyl substituent at C-2 (3b) and the nitro group at C-4 (3h) in chalcone scaffold. The fourteen chalcones inhibited the NO production in LPS-stimulated macrophages and showed potential for interaction on the active site of the iNOS enzyme. Finally, 3b and 3h showed the highest selectivity to the AGS cells line. Th...
Source: Chemistry and Biodiversity - August 30, 2023 Category: Biochemistry Authors: Jessica Rodrigues Pereira de Oliveira Borlot Luna Schlittler Dos Santos Guilherme Jos é Schwarzt Sampaio Augusto Santos Borges Ricardo Pereira Rodrigues Rita de C ássia Ribeiro Gonçalves Reginaldo Bezerra Dos Santos Rodrigo Rezende Kitagawa Source Type: research
Preclinical evaluation of a dual-receptor targeted tracer < sup > 68 < /sup > GaGa-HX01 in 10 different subcutaneous and orthotopic tumor models
CONCLUSIONS: [68Ga]Ga-HX01, as a dual target imaging agent, exhibited superior in vivo performance in different subcutaneous and orthotopic mice models of human tumors over [18F]FDG and its respectively mono-receptor targeted agents, which warrants the future clinical translation for tumor imaging.PMID:37642706 | DOI:10.1007/s00259-023-06412-z
Source: Molecular Medicine - August 29, 2023 Category: Molecular Biology Authors: Xiaoying Lv Xiangming Song Yu Long Dexing Zeng Xiaoli Lan Yongkang Gai Source Type: research
Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets
CONCLUSIONS: Tumor genomic profiling can facilitate the selection of targeted/immunotherapies, as well as clinical trial enrollment, for patients with cervical cancer.PMID:37643132 | DOI:10.1158/1078-0432.CCR-23-1078
Source: Clinical Cancer Research - August 29, 2023 Category: Cancer & Oncology Authors: Claire F Friedman Vignesh Ravichandran Kathryn Miller Chad Vanderbilt Qin Zhou Alexia Iasonos Malavika Vivek Pamela Mishra Mario M Leitao Vance A Broach Yukio Sonoda Chrisann Kyi Dmitriy Zamarin Roisin E O'Cearbhaill Jason Konner Michael F Berger Britta W Source Type: research
Germline CDH1 variants in hereditary diffuse gastric cancer syndrome with focus on younger women
CONCLUSIONS: Young women carrying germline CDH1 variants with DGC are comparatively frequent in the HDGC syndrome, and potentially at higher risk to develop DGC particularly in low-incidence areas for GC.PMID:37639007 | DOI:10.1007/s00432-023-05318-5
Source: Clinical Breast Cancer - August 28, 2023 Category: Cancer & Oncology Authors: Giovanni Corso Giovanni Comelli Paolo Veronesi Beatrice Bianchi Salvatore Petitto Andrea Polizzi Antonia Girardi Antonio Cioffi Carlo La Vecchia Vincenzo Bagnardi Francesca Magnoni Source Type: research
Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis
Exp Cell Res. 2023 Aug 26:113757. doi: 10.1016/j.yexcr.2023.113757. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a common malignancy worldwide nowadays and liver metastasis is the primary cause of death in patients with CRC. Although lysosomal integral membrane protein 2 (LIMP2) has been reported to play important roles in gastric cancer and prostate cancer, its role in CRC remains unclear. The aim of this study was to investigate the function of LIMP2 in CRC invasion and migration, along with the potential underlying molecular mechanisms. We found that LIMP2 levels were higher in CRC tissues compared to adjace...
Source: Experimental Cell Research - August 28, 2023 Category: Cytology Authors: Yu Tian Liumei Liang Junxiong Chen Jiaqi Liu Yixi Su Mengchen Shi Weiqian Li Jingdan Zhang Yanchun Feng Lingyuan He Huanliang Liu Xiangling Yang Source Type: research
Retraction: Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells < em > in vitro < /em > and < em > in vivo < /em >
Aging (Albany NY). 2023 Aug 28;undefined. doi: 10.18632/aging.205020. Online ahead of print.NO ABSTRACTPMID:37635421 | DOI:10.18632/aging.205020
Source: Aging - August 28, 2023 Category: Biomedical Science Authors: Liang Shi Zhenyong Wang Xiuchao Geng Yuhao Zhang Ziqing Xue Source Type: research
Germline CDH1 variants in hereditary diffuse gastric cancer syndrome with focus on younger women
CONCLUSIONS: Young women carrying germline CDH1 variants with DGC are comparatively frequent in the HDGC syndrome, and potentially at higher risk to develop DGC particularly in low-incidence areas for GC.PMID:37639007 | DOI:10.1007/s00432-023-05318-5
Source: Clinical Genitourinary Cancer - August 28, 2023 Category: Cancer & Oncology Authors: Giovanni Corso Giovanni Comelli Paolo Veronesi Beatrice Bianchi Salvatore Petitto Andrea Polizzi Antonia Girardi Antonio Cioffi Carlo La Vecchia Vincenzo Bagnardi Francesca Magnoni Source Type: research
Retraction: Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells < em > in vitro < /em > and < em > in vivo < /em >
Aging (Albany NY). 2023 Aug 28;undefined. doi: 10.18632/aging.205020. Online ahead of print.NO ABSTRACTPMID:37635421 | DOI:10.18632/aging.205020
Source: Aging - August 28, 2023 Category: Biomedical Science Authors: Liang Shi Zhenyong Wang Xiuchao Geng Yuhao Zhang Ziqing Xue Source Type: research
Association between history of cholecystectomy and risk of gastric cancer: a meta-analysis of epidemiological studies
CONCLUSION: This meta-analysis suggests that a history of cholecystectomy may be associated with an increased risk of gastric cancer.PMID:37640459 | DOI:10.1136/bmjopen-2021-057138
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Mei Sun Tianyi Ma Huawei Yuan Source Type: research
Survival of 48866 cancer patients: results from Nantong area, China
CONCLUSION: Overall survival improved over the years, although the improvement at some sites was not significant. The observed survival varies from region to region, reflecting differences in the patterns of major sites, disparities in proportions of hospitalization, and demographic characteristics.PMID:37637071 | PMC:PMC10455932 | DOI:10.3389/fonc.2023.1244545
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Gao-Ren Wang Hong Xu Hai-Zhen Chen Yong-Sheng Chen Zhuo-Jian Ni Li-Yun Fan Ai-Hong Zhang Pei-Pei Xu Yun Qian Bo Cai Jian-Guo Chen Source Type: research
IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
NAR Cancer. 2023 Aug 24;5(3):zcad046. doi: 10.1093/narcan/zcad046. eCollection 2023 Sep.ABSTRACTConstant communication between mitochondria and nucleus ensures cellular homeostasis and adaptation to mitochondrial stress. Anterograde regulatory pathways involving a large number of nuclear-encoded proteins control mitochondrial biogenesis and functions. Such functions are deregulated in cancer cells, resulting in proliferative advantages, aggressive disease and therapeutic resistance. Transcriptional networks controlling the nuclear-encoded mitochondrial genes are known, however alternative splicing (AS) regulation has not b...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Vasiliki Papadaki Zoi Erpapazoglou Maria Kokkori Malgorzata Ewa Rogalska Myrto Potiri Andrada Birladeanu Eleni N Tsakiri Hassan Ashktorab Duane T Smoot Katerina Papanikolopoulou Martina Samiotaki Panagiota Kafasla Source Type: research
Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis
Exp Cell Res. 2023 Aug 26:113757. doi: 10.1016/j.yexcr.2023.113757. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a common malignancy worldwide nowadays and liver metastasis is the primary cause of death in patients with CRC. Although lysosomal integral membrane protein 2 (LIMP2) has been reported to play important roles in gastric cancer and prostate cancer, its role in CRC remains unclear. The aim of this study was to investigate the function of LIMP2 in CRC invasion and migration, along with the potential underlying molecular mechanisms. We found that LIMP2 levels were higher in CRC tissues compared to adjace...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Yu Tian Liumei Liang Junxiong Chen Jiaqi Liu Yixi Su Mengchen Shi Weiqian Li Jingdan Zhang Yanchun Feng Lingyuan He Huanliang Liu Xiangling Yang Source Type: research
STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer
CONCLUSION: TRIM21 is a tumor-suppressive gene in gastric cancer, and its transcriptional activity is inhibited by STAT1.PMID:37639009 | DOI:10.1007/s00432-023-05307-8
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Chengdong Huo Yanmei Gu Daijun Wang Xiaoxia Zhang Futian Tang Bin Zhao Tao Liu Wenting He Yumin Li Source Type: research
