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Specialty: Neurology
Therapy: Stem Cell Therapy
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Total 527 results found since Jan 2013.
Retraction notice to "Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3" Brain Res. Bull. 172 (2021) 220-228
Brain Res Bull. 2022 Sep 9;189:153. doi: 10.1016/j.brainresbull.2022.09.005. Online ahead of print.NO ABSTRACTPMID:36095955 | DOI:10.1016/j.brainresbull.2022.09.005
Source: Brain Research Bulletin - September 12, 2022 Category: Neurology Authors: Zhibing Ai Chaohui Cheng Lan Zhou Songhe Yin Lei Wang Yong Liu Source Type: research
Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke
Ischemic stroke is becoming one of the most common causes of death and disability in developed countries. Since current therapeutic options are quite limited, focused on acute reperfusion therapies that are hampered by a very narrow therapeutic time window, it is essential to discover novel treatments that not only stop the progression of the ischemic cascade during the acute phase, but also improve the recovery of stroke patients during the sub-acute or chronic phase. In this regard, several studies have shown that endothelial progenitor cells (EPCs) can repair damaged vessels as well as generate new ones following cerebr...
Source: Frontiers in Neurology - September 8, 2022 Category: Neurology Source Type: research
Bone marrow-derived mesenchymal stem cells overexpressed with miR-182-5p protects against brain injury in a mouse model of cerebral ischemia
This study investigates whether overexpressing miR-182-5p in bone marrow-derived mesenchymal stem cells (BM-MSCs) could potentiate the neuroprotective effects of BM-MSCs in a mouse model of ischemic brain injury.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2022 Category: Neurology Authors: Mingyang Deng, Jianyang Liu, Jialin He, Ziwei Lan, Shuangxi Cheng, Zhiping Hu, Han Xiao Source Type: research
Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
AbstractNeurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are the most common NDs. A rise in the absolute number of individuals affected with these diseases indicates that the current treatment strategies in management and prevention of these debilitating diseases are not effective sufficiently. Therefore, novel treatment strategies are being explored to cure these diseases by addressing the causative mechanisms at the molecular level. Advanced therapies like gene therapy (gene ed...
Source: Neurological Sciences - September 6, 2022 Category: Neurology Source Type: research
Endogenous Neural Stem Cell –induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
AbstractIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments include transplantation of exogenous stem cells but also stimulating endogenous neural ...
Source: Translational Stroke Research - September 3, 2022 Category: Neurology Source Type: research
Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury via Neuroinflammation Regulation
In this study, we aimed to evaluate and compare the thera peutic effects of NSC and GBC therapies post-CA. In in vitro studies, BV2 cells underwent oxygen–glucose deprivation (OGD) for three hours and were then treated with GBC or co-cultured with human NSCs (hNSCs). Microglial polarization phenotype and TLR4/NLRP3 inflammatory pathway proteins were detected by immunofluorescence staining. Twenty-four Wistar rats were ra ndomly assigned to three groups (control, GBC, and hNSCs, N = 8/group). After 8 min of asphyxial CA, GBC was injected intraperitoneally or hNSCs were administered intranasally in the treatment gr...
Source: Translational Stroke Research - August 3, 2022 Category: Neurology Source Type: research
Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges
AbstractIt is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells (MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander effects rather than to cell replacement in infarcted areas. This therapeutic plasticity is due to MSCs ’ ability to secrete a broad range of bioactive molecules including growth factors, trophic factors, cytokines, chemokines, and extracellular vesicles, overall known as the secretome. The secretome derivatives, such as conditioned medium (CM) or purified extracellular vesicles (EVs), exert remarka ble advantages over MSC transplantat...
Source: Molecular Neurobiology - August 3, 2022 Category: Neurology Source Type: research
Treatments in Ischemic Stroke: Current and Future
Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well as strategies able to improve ischemic stroke management from the pre-hospital setting is needed.Summary: The pathophysiology of ischemic stroke involves multiple pathways resulting in cerebral artery obstruction and brain tissue ischemia. To date, the only approved drug for acute ischemic stroke is intravenous thrombolytic alt...
Source: European Neurology - August 2, 2022 Category: Neurology Source Type: research
Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
AbstractCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke,23Na MRI evaluates treatment efficacy within 24 h after middle cerebral artery occlusion, showing recovery of sodium homeostasis and lesion reduction in specimens treated with hMSC while1H MRS identifi...
Source: Translational Stroke Research - July 28, 2022 Category: Neurology Source Type: research
Involvement of T-bet and GATA3 transcription factors in Mesenchymal stem cells and royal jelly combination treatment in brain stroke
Stroke as a common non-communicable disease can manifest itself as ischemic (87%) and hemorrhagic.1 However, the viable cells surrounding the infarct core have been shown to be at risk for infarct and apoptosis. Some therapeutic approaches are trying to improve neuronal recovery in the region and reduce post-stroke disability.2,3 Currently, to dissolve the clot and rescue the surrounding cells in the ischemic condition, tissue plasminogen activator (tPA) is administrated within the first three hours of the onset of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2022 Category: Neurology Authors: Mohammad Kazemi Arababadi, Mohammad Reza Rahmani, Fatemeh Asadi, Ahmad Shabanizadeh, Aliakbar Yousefi-Ahmadipour Source Type: research
Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain
Exp Neurol. 2022 Jul 19:114177. doi: 10.1016/j.expneurol.2022.114177. Online ahead of print.ABSTRACTIschemic stroke is a leading cause of morbidity and mortality, with limited treatments that can facilitate brain regeneration. Neural progenitor cells (NPCs) hold promise for replacing tissue lost to stroke, and biomaterial approaches may improve their efficacy to overcome hurdles in clinical translation. The immune response and its role in stroke pathogenesis and regeneration may interplay with critical mechanisms of stem cell and biomaterial therapies. Cellular therapy can modulate the immune response to reduce toxic neuro...
Source: Experimental Neurology - July 22, 2022 Category: Neurology Authors: Myles R McCrary Michael Q Jiang Kaleena Jesson Xiaohuan Gu Meghan T Logun Anika Wu Nathan Gonsalves Lohitash Karumbaiah Shan Ping Yu Ling Wei Source Type: research
Metabolic Switching of Cultured Mesenchymal Stem Cells Creates Super Mitochondria in Rescuing Ischemic Neurons
AbstractTransfer of healthy mitochondria from mesenchymal stem cells (MSCs) to ischemic neurons represents a potent stroke therapeutic. MSCs were grown under ambient conditions (nMSCs) or a metabolic switching paradigm by alternating galactose and glucose in medium (sMSCs) and then assayed for oxygen consumption rates using the Seahorse technology. Subsequently, primary neurons were subjected to oxygen glucose deprivation (OGD) and then co-cultured with either nMSCs or sMSCs. Compared to nMSCs, sMSCs displayed higher basal energy production, larger spare respiratory capacity, greater ATP production, and decreased proton le...
Source: NeuroMolecular Medicine - July 20, 2022 Category: Neurology Source Type: research
Adipose-derived mesenchymal stem cells reduced transient cerebral ischemia injury by modulation of inflammatory factors and AMPK signaling
In this study, by releasing the clips, the reperfusion period was extended to 96hours, and two hours after cerebral ischemia, animals received adipose-derived MSCs. MSCs were isolated from the inguinal fat pads of rats and injected into two-vessel occlusion (2VO) rats 1hour after ischemia induction. Ninety-six hours after 2VO induction, behavioral and molecular tests were assessed. Adipose-derived MSCs treatment improves neurological scores, passive avoidance memory, and novel object recognition tests in the 2VO model compared to 2VO rats (P<0.001). MSCs treatment decreased TNF-α (P<0.01) and IL-6 (P<0.01) and ap...
Source: Behavioural Brain Research - July 9, 2022 Category: Neurology Authors: Mina Ranjbaran Reyhaneh Vaali Zahra Yaghoobi Fardin Sehati Vida Jashn Sevda Mahdipour Kolur Fariba Akhondzadeh Ghorbangol Ashabi Source Type: research
