Stroke RSS Page 14

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Specialty: Neurology
Therapy: Stem Cell Therapy

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Total 527 results found since Jan 2013.

Hypoxic postconditioning promotes neurogenesis by modulating the metabolism of neural stem cells after cerebral ischemia
In conclusion, cerebral ischemia modulated the FAO and glycolysis of neural stem cells. HPC promoted the proliferation and migration of neural stem cells after MCAO, and these effects may be related to the regulation of metabolism, including FAO and glycolysis.PMID:34563509 | DOI:10.1016/j.expneurol.2021.113871
Source: Experimental Neurology - September 26, 2021 Category: Neurology Authors: Haiyan Li Sijie Li Changhong Ren Chen Gao Ning Li Chunxiu Wang Lin Wang Wenbo Zhao Xunming Ji Kunlin Jin Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

GATA3 improves the protective effects of bone marrow-derived mesenchymal stem cells against ischemic stroke induced injury by regulating autophagy through CREG
CONCLUSION: Our results indicated that GATA3 overexpression improved the therapeutic effects of rBMSCs transplantation against ischemic stroke induced injury by regulating autophagy through CREG.PMID:34500038 | DOI:10.1016/j.brainresbull.2021.09.001
Source: Brain Research Bulletin - September 9, 2021 Category: Neurology Authors: Yongchang Li Wei Zhong Qianyi Huang Bing Lang Xiangqi Tang Source Type: research

GATA3 improves the protective effects of bone marrow-derived mesenchymal stem cells against ischemic stroke induced injury by regulating autophagy through CREG
CONCLUSION: Our results indicated that GATA3 overexpression improved the therapeutic effects of rBMSCs transplantation against ischemic stroke induced injury by regulating autophagy through CREG.PMID:34500038 | DOI:10.1016/j.brainresbull.2021.09.001
Source: Brain Research - September 9, 2021 Category: Neurology Authors: Yongchang Li Wei Zhong Qianyi Huang Bing Lang Xiangqi Tang Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564
Source: Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Mesenchymal Stem Cell (MSC) –Derived Extracellular Vesicles Protect from Neonatal Stroke by Interacting with Microglial Cells
Abstract Mesenchymal stem cell (MSC)-based therapies are beneficial in models of perinatal stroke and hypoxia –ischemia. Mounting evidence suggests that in adult injury models, including stroke, MSC-derived small extracellular vesicles (MSC-sEV) contribute to the neuroprotective and regenerative effects of MSCs. Herein, we examined if MSC-sEV protect neonatal brain from stroke and if this effect is mediat ed via communication with microglia. MSC-sEV derived from bone marrow MSCs were characterized by size distribution (NanoSight™) and identity (protein markers). Studies in microglial cells isolated from the injured o...
Source: Neurotherapeutics - July 7, 2021 Category: Neurology Source Type: research

Angiogenin in the Neurogenic Subventricular Zone After Stroke
Ischemic stroke is a leading cause of death and disability worldwide with effective acute thrombolytic treatments. However, brain repair mechanisms related to spontaneous or rehabilitation-induced recovery are still under investigation, and little is known about the molecules involved. The present study examines the potential role of angiogenin (ANG), a known regulator of cell function and metabolism linked to neurological disorders, focusing in the neurogenic subventricular zone (SVZ). Angiogenin expression was examined in the mouse SVZ and in SVZ-derived neural stem cells (NSCs), which were exposed to exogenous ANG treat...
Source: Frontiers in Neurology - June 21, 2021 Category: Neurology Source Type: research

Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1
In conclusion, BMSCs reverse microglia from pro-inflammatory type TNF-a microglia to anti-inflammatory type CD206 microglia in the infarct region of MCAO rats (3rd to 7th days post BMSC transplantation), through triggering of CX3CL1 secretion. Therefore, the potential effects of CX3CL1 secreted by BMSCs would provide an insight for stem cell-dependent therapeutic strategies in treating ischaemic stroke-associated disorders.PMID:33969675 | DOI:10.5114/fn.2021.105129
Source: Folia Neuropathologica - May 10, 2021 Category: Neurology Authors: Xiu-Juan Bai Lei Hao Yan-E Guo Xiao-Bing Shi Wei-Ping Wu Source Type: research

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