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Specialty: Neuroscience
Therapy: Stem Cell Therapy

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Total 104 results found since Jan 2013.

Nitrogen-doped carbon nanocages and human umbilical cord mesenchymal stem cells cooperatively inhibit neuroinflammation and protect against ischemic stroke
This study aimed to explore the synergistic effects of nitrogen-doped carbon nanocages (NCNCs) and human umbilical cord mesenchymal stem cells (HUC-MSCs) on ischemic stroke and investigate the potential underlying mechanisms.Main methodsThe properties of NCNCs were analyzed by transmission electron microscopy, and the markers of HUC-MSCs were detected by flow cytometry. The cell toxicity of NCNCs was evaluated by MTT. Mice were induced cerebral infarction by transient middle cerebral artery occlusion (MCAO). NCNCs or HUC-MSCs or HUC-MSCs-NCNCs were intravenously injected thirty minutes after reperfusion. The infarct volume...
Source: Neuroscience Letters - June 21, 2019 Category: Neuroscience Source Type: research

Neural Stem Cells Transfected with Leukemia Inhibitory Factor Promote Neuroprotection in a Rat Model of Cerebral Ischemia
AbstractLeukemia inhibitory factor (LIF) contributes to the neuroprotection by neural stem cells (NSCs) after ischemic stroke. Our aim was to explore whether LIF-transfected NSCs (LIF-NSCs) can ameliorate brain injury and promote neuroprotection in a rat model of cerebral ischemia. To accomplish this goal, we transfected NSCs with a lentivirus carrying the LIF gene to stably overexpress LIF. The LIF-NSCs reduced caspase 3 activation under conditions of oxygen-glucose deprivationin vitro. Transient cerebral ischemia was induced in rats by 2  h of middle cerebral artery occlusion (MCAo), and LIF-NSCs were intravenously inje...
Source: Neuroscience Bulletin - June 18, 2019 Category: Neuroscience Source Type: research

Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model
Publication date: Available online 16 April 2019Source: NeuroscienceAuthor(s): Masahito Nakazaki, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Junpei Suzuki, Yuichi Sasaki, Hiroshi Nagahama, Kazuo Hashi, Jeffery D. Kocsis, Osamu HonmouAbstractCerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood–brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atr...
Source: Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

MicroRNAs and Regeneration in Animal Models of CNS Disorders.
Abstract microRNAs (miRNAs) are recently identified small RNA molecules that regulate gene expression and significantly influence the essential cellular processes associated with CNS repair after trauma and neuropathological conditions including stroke and neurodegenerative disorders. A number of specific miRNAs are implicated in regulating the development and propagation of CNS injury, as well as its subsequent regeneration. The review focuses on the functions of the miRNAs and their role in brain recovery following CNS damage. The article introduces a brief description of miRNA biogenesis and mechanisms of miRNA...
Source: Neurochemical Research - March 14, 2019 Category: Neuroscience Authors: Roitbak T Tags: Neurochem Res Source Type: research

Blood vessels as a scaffold for neuronal migration
Publication date: Available online 6 March 2019Source: Neurochemistry InternationalAuthor(s): Teppei Fujioka, Naoko Kaneko, Kazunobu SawamotoAbstractNeurogenesis and angiogenesis share regulatory factors that contribute to the formation of vascular networks and neuronal circuits in the brain. While crosstalk mechanisms between neural stem cells (NSCs) and the vasculature have been extensively investigated, recent studies have provided evidence that blood vessels also play an essential role in neuronal migration in the brain during development and regeneration. The mechanisms of the neuronal migration along blood vessels, r...
Source: Neurochemistry International - March 8, 2019 Category: Neuroscience Source Type: research

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders
Publication date: Available online 14 November 2018Source: Progress in NeurobiologyAuthor(s): Sydney Zarriello, Julian Tuazon, Sydney Corey, Samantha Schimmel, Mira Rajani, Anna Gorsky, Diego Incontri, Bruce D. Hammock, Cesar V. BorlonganAbstractSoluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway. EETs exert a variety of largely beneficial effects in the context of inflammation and vascular regulation. sEH inhibition is shown to be therapeutic in several cardiovascu...
Source: Progress in Neurobiology - November 14, 2018 Category: Neuroscience Source Type: research

CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients
In conclusion, in this study NSE indicated some activity of the CD45−CD34 + CXCR7+, CD45−CD34 + and CD45−CD34 + CXCR4+ stem/progenitor cells in the first 7 days after ischemic stroke. Additionally, this study supports the thesis that NSE might be a valuable prognostic marker in acute ischemic stroke.
Source: Neurochemistry International - August 17, 2018 Category: Neuroscience Source Type: research

The membrane mesenchymal stem cell derived conditioned medium exerts neuroprotection against focal cerebral ischemia by targeting apoptosis
ConclusionThe results of this study indicate that treatment with AMSC-CM improves the pathological effects in the acute phase of cerebral ischemia. These findings establish a substantial foundation for stroke therapy and future research.
Source: Journal of Chemical Neuroanatomy - August 17, 2018 Category: Neuroscience Source Type: research

Neural stem cell therapies and hypoxic-ischemic brain injury
Publication date: Available online 21 May 2018Source: Progress in NeurobiologyAuthor(s): Lei Huang, Lubo ZhangAbstractHypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic effects of neural stem cell-based treatments for hypoxic-ischemic brain injury. There are two major strategies of neural stem cell-based therapies: transplanting exogenous neural stem cells and boosting self-repair of endogenous neural stem cells. Neural stem cell transplantation has been proved to improve functional recovery ...
Source: Progress in Neurobiology - July 10, 2018 Category: Neuroscience Source Type: research

Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen –Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis
In this study, we identified the role of exosomal microRNA-181b-5p (181b-Exos) in regulating post-stroke angiogenesis. The results of migration assay and capillary network formation assay showed that exosomes secreted by ADSCs (ADSCs-Exos) promoted the mobility and angiogenesis of brain microvascular endothelial cells (BMECs) after oxygen-glucose deprivation (OGD). Quantitative real-time polymerase chain reaction (qRT-PCR) showed that microRNA-212-5p (miR-212-5p) and miR-181b-5p were upregulated in BMECs subjected to the brain extract of the middle cerebral artery occlusion rats. The migration distance and tube length were...
Source: Journal of Molecular Neuroscience - April 29, 2018 Category: Neuroscience Source Type: research

Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia
Publication date: 1 June 2018 Source:Neuroscience, Volume 380 Author(s): Krista M. Rodgers, Jared T. Ahrendsen, Olivia P. Patsos, Frank A. Strnad, Joan C. Yonchek, Richard J. Traystman, Wendy B. Macklin, Paco S. Herson Replacement of dead neurons following ischemia, either via enhanced endogenous neurogenesis or stem cell therapy, has long been sought. Unfortunately, while various therapies that enhance neurogenesis or stem cell therapies have proven beneficial in animal models, they have all uniformly failed to truly replace dead neurons in the ischemic core to facilitate long-term recovery. Remarkably, we observe robust...
Source: Neuroscience - April 17, 2018 Category: Neuroscience Source Type: research

Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
Publication date: 14 February 2018 Source:Neuroscience Letters, Volume 666 Author(s): Nina Kosi, Ivan Alić, Iva Salamon, Dinko Mitrečić Although transplantation of stem cells improves recovery of the nervous tissue, little is known about the influence of different brain regions on transplanted cells. After we confirmed that cells with uniform differentiation potential can be generated in independent experiments, one million of neural stem cells isolated from B6.Cg-Tg(Thy1-YFP)16Jrs/J mouse embryos were transplanted into the brain 24 h after induction of stroke. The lateral ventricles, the corpus callosum and the stri...
Source: Neuroscience Letters - January 4, 2018 Category: Neuroscience Source Type: research

Transplantation of feeder ‐free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia
Abstract The use of human induced pluripotent stem cells (hiPSCs) eliminates the ethical issues associated with fetal or embryonic materials, thus allowing progress in cell therapy research for ischemic stroke. Strict regulation of cell therapy development requires the xeno‐free condition to eliminate clinical complications. Maintenance of hiPSCs with feeder‐free condition presents a higher degree of spontaneous differentiation in comparison with conventional cultures. Therefore, feeder‐free derivation might be not ideal for developing transplantable hiPSC derivatives. We developed the feeder‐free condition for dif...
Source: Journal of Neuroscience Research - November 7, 2017 Category: Neuroscience Authors: Yulius Hermanto, Tadashi Sunohara, Ahmad Faried, Yasushi Takagi, Jun Takahashi, Takakuni Maki, Susumu Miyamoto Tags: RESEARCH ARTICLE Source Type: research