Monoamine oxidase polymorphisms in rhesus and Japanese macaques (Macaca mulatta and M. fuscata)
Discussion of our results are centered on implications for future investigations that aim to better understand the functionality of monoamine oxidase polymorphisms in the context of primate social behavior. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - November 17, 2019 Category: Neuroscience Source Type: research

Long-Term Administration of High-Dose Methylphenidate-Induced Cerebellar Morphology and Function Damage in Adult Rats
Publication date: Available online 15 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Amir Raoofi, Abass Aliaghaei, Mohammad-Amin Abdollahifar, Mahdi Eskandarian Boroujeni, Sara Sadat javadinia, Hadi Atabati, Beheshteh AbouhamzehAbstractBackground and AimStated in previous studies, physicians are typically prescribing methylphenidate (MPH), commonly known as Ritalin, for children diagnosed with attention deficit hyperactivity disorder (ADHD). Nevertheless, researchers have not still understood mechanisms of this stimulant medication. Research has also found an association between apoptosis signaling pathway...
Source: Journal of Chemical Neuroanatomy - November 17, 2019 Category: Neuroscience Source Type: research

Alpha Lipoic Acid ameliorates THIM-induced prefrontal cell loss and abnormal enzymatically contents in the developing rat
Publication date: Available online 15 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Mehrazin Noshadian, Zahra Namvarpour, Abdollah Amini, Amir Raoofi, Hadi Atabati, Yousef Sadeghi, Abass Aliaghaei, Modammad-Amin AbdollahifarAbstractThimerosal (THIM) is a common preservative used in many pharmaceutical drugs, vaccines, cosmetics and many other products. Today, it was somewhat clear that Thimerosal (THIM) is a neurotoxicant preservative. We aimed to use of a suitable agent for preventing of THIM side effects on brain. Therefore, in this research, the protective effects of Alpha Lipoic Acid (ALA), against TH...
Source: Journal of Chemical Neuroanatomy - November 17, 2019 Category: Neuroscience Source Type: research

Swimming reduces fatty acids-associated hypothalamic damage in mice
Publication date: Available online 11 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Pedro Augusto Silva Nogueira, Miriam Pimenta Pereira, Jeferson José Gomes Soares, Juliana de Assis Silva Gomes, Daniele Lisboa Ribeiro, Daniela Soares Razolli, Licio Augusto Velloso, Morun Bernardino Neto, Renata Graciele ZanonAbstractThe arcuate and the paraventricular and lateral hypothalamic nuclei, related to hunger and satiety control, are generally compromised by excess fatty acids. In this situation, fatty acids cause inflammation via TLR4 (toll like receptor 4) and the nuclei become less responsive to the ho...
Source: Journal of Chemical Neuroanatomy - November 12, 2019 Category: Neuroscience Source Type: research

Maternal exposure to busulfan reduces the cell number in the somatosensory cortex associated with delayed somatic and reflex maturation in neonatal rats
Publication date: Available online 7 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Henrique J.C.B. Gouveia, Raul Manhães-de-Castro, Bárbara J.R. Costa-de-Santana, Carolina R. Mendonça, Glayciele Leandro de Albuquerque, Diego Bulcão Visco, Diego Cabral Lacerda, Ana Elisa ToscanoAbstractBusulfan is a bifunctional alkylating agent used for myeloablative conditioning and in the treatment of chronic myeloid leukemia due to its ability to cause DNA damage. However, in rodent experiments, busulfan presented a potential teratogenic and cytotoxic effect. Studies have evaluated the effec...
Source: Journal of Chemical Neuroanatomy - November 8, 2019 Category: Neuroscience Source Type: research

Serotonin systems in three socially communicating teleost species, the grunting toadfish (Allenbatrachus grunniens), a South American marine catfish (Ariopsis seemannii), and the upside-down catfish (Synodontis nigriventris)
Publication date: Available online 6 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Elisabeth Rosner, Boris P. Chagnaud, Mario F. WullimannAbstractWe investigated immunohistochemically the distribution of serotonergic cell populations in three teleost species (one toadfish, Allenbatrachus grunniens, and two catfishes, Synodontis nigriventris and Ariopsis seemanni). All three species exhibited large populations of 5-HT positive neurons in the paraventricular organ (PVO) and the dorsal (Hd) and caudal (Hc) periventricular hypothalamic zones, plus a smaller one in the periventricular pretectum, a few cells in...
Source: Journal of Chemical Neuroanatomy - November 7, 2019 Category: Neuroscience Source Type: research

Fluoxetine attenuates stress-induced depressive-like behavior through modulation of hippocampal GAP43 and neurogenesis in male rats
This study provides evidence that fluoxetine is a potent enhancer of GAP-43, a protein related to the neuronal plasticity, in the hippocampus of the rat model of depression. Interestingly, our results showed that although fluoxetine significantly is effective in increasing BrdU positive cells, it is more effective in increasing the neurite formation compared with neurogenesis.The results support the idea that antidepressants can promote neuronal plasticity. We concluded that the increase of GAP-43- induced neurite formation may be an important mechanism by which fluoxetine augments hippocampal neuroplasticity and play its ...
Source: Journal of Chemical Neuroanatomy - November 7, 2019 Category: Neuroscience Source Type: research

Isorhamnetin exerts neuroprotective effects in STZ-induced diabetic rats via attenuation of oxidative stress, inflammation and apoptosis
ConclusionThese findings suggested that isorhamnetin has potential effects as neuroprotective agents against diabetes-related changes in the brain. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - November 5, 2019 Category: Neuroscience Source Type: research

Conditioned medium obtained from human amniotic mesenchymal stem cells attenuates focal cerebral ischemia/ reperfusion injury in rats by targeting mTOR pathway
Publication date: Available online 28 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Donya Nazarinia, Nahid Aboutaleb, Raheleh Gholamzadeh, Solmaz Nasseri Maleki, Behnaz Mokhtari, Mahin NikougoftarAbstractConditioned medium obtained from human amniotic mesenchymal stem cells (hAMSC-CM) was recently shown to have many antioxidant, antiapoptotic and proangiogenic growth factors. The present study was performed to investigate whether protective effects of hAMSC-CM against focal cerebral ischemia/ reperfusion (I/R) injury is associated with modulation of the mammalian target of rapamycin (mTOR) pathway.A rat mo...
Source: Journal of Chemical Neuroanatomy - October 30, 2019 Category: Neuroscience Source Type: research

Tyrosine hydroxylase-immunoreactive neurons in the brain of tadpole of the narrow mouthed frog Microhyla ornata
In this study, we report the distribution of catecholaminergic neurons in different areas of the brain in the tadpole of Microhyla ornata at metamorphic climax stage. Application of antisera against tyrosine hydroxylase (TH) revealed the presence of catecholaminergic cells and fibres in the olfactory bulb, the telencephalon, the diencephalon, the mesencephalon, the spinal cord and the pituitary gland. Whereas densest aggregations of TH-ir fibres were noticed in the nucleus accumbens and the amygdala pars medialis regions of the telencephalon, highest population of TH-ir cells with dorsolaterally and rostrocaudally oriented...
Source: Journal of Chemical Neuroanatomy - October 27, 2019 Category: Neuroscience Source Type: research

Reproductive status-dependent dynorphin and neurokinin B gene expression in female Damaraland mole-rats
Publication date: Available online 24 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Cornelia Voigt, Nigel BennettAbstractDamaraland mole rats (Fukomys damarensis) are cooperatively breeding, subterranean mammals, which exhibit high reproductive skew. Reproduction is monopolized by the dominant female of the group, while subordinates are physiologically suppressed. The blockade of reproduction results from an inhibition of ovulation, which is caused by inadequate secretion of luteinizing hormone (LH) from the pituitary, which in turn might be brought about by a disruption of the normal GnRH secretion from t...
Source: Journal of Chemical Neuroanatomy - October 25, 2019 Category: Neuroscience Source Type: research

Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP
Conclusionthe present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - October 25, 2019 Category: Neuroscience Source Type: research

Patterns of c-Fos expression in telencephalic areas of Tropidurus hygomi (Iguania: Tropiduridae) exposed to different social contexts
Publication date: Available online 20 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Rodrigo Santos Siqueira, José Ronaldo dos Santos, Edson Lima Santos, Auderlan Mendonça de Gois, Eduardo José dos Reis DiasAbstractSocial behavior in lizards contributes to understanding biological standards and provides models for structuring research about neural mechanisms. Studies have confirmed the effectiveness of comparative models and evidence has contributed to clarifying adult brain plasticity phenomenon when exposed to different stimuli. The expression of c-Fos has been widely used to identify...
Source: Journal of Chemical Neuroanatomy - October 21, 2019 Category: Neuroscience Source Type: research

“Anatomical mechanism of ideation, association and attention” [1895] and “Certain points in neurological histophysiology” [1896]: Cajal’s conjectures, then and now
Publication date: Available online 9 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Elena I. Antonakou, Lazaros C. TriarhouAbstractThe purpose of this article is two-fold: first, to preserve, in updated English translations, two theoretical papers written by Santiago Ramón y Cajal (1852–1934) in 1895 and 1896 under the titles, “Conjectures on the anatomical mechanism of ideation, association and attention” and “Conjectural interpretations of certain points in neurological histophysiology”; and second, to set some of the ideas proposed by Cajal in a modern perspective. In...
Source: Journal of Chemical Neuroanatomy - October 10, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: November 2019Source: Journal of Chemical Neuroanatomy, Volume 101Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - October 9, 2019 Category: Neuroscience Source Type: research

Neuroanatomical relationship between the cholinergic and tachykininergic systems in the adult human brainstem: an immunohistochemical study
Publication date: Available online 1 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): P. Marcos, R. CoveñasAbstractThe cholinergic system plays an important role in brain homeostasis and interacts with the neuropeptidergic systems, and the functional relationships between both systems are well known. However, in the brainstem the possible physiological interactions between neurokinins and acetylcholine are unknown, although both substances have been detected in the same brainstem nuclei and have been implicated in similar functions controlled from brainstem regions such as some cranial motor nuclei. Th...
Source: Journal of Chemical Neuroanatomy - October 2, 2019 Category: Neuroscience Source Type: research

Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine
Publication date: Available online 30 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Moulay Mustapha Bouyatas, Abdellatif Abbaoui, Halima GamraniAbstractLead (Pb) is a non physiological metal that has been implicated in toxic processes affecting several organs and biological systems, including the central nervous system. Several studies have focused on changes in lead-associated neurobehavioral and neurochemical alterations that occur due to Pb exposure. The present study evaluates the effects of acute and chronic Pb acetate exposure on serotoninergic and dopaminergic systems within the dorsal raphe nucle...
Source: Journal of Chemical Neuroanatomy - September 30, 2019 Category: Neuroscience Source Type: research

Neurotrophin Mediated HPA Axis Dysregulation in Stress Induced Genesis of Psychiatric Disorders: Orchestration by Epigenetic Modifications
Publication date: Available online 27 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Ashutosh Kumar, Pavan Kumar, Vikas Pareek, Muneeb A. Faiq, Ravi K. Narayan, Khursheed Raza, Pranav Prasoon, Vivek K. SharmaAbstractApart from their established role in embryonic development, neurotrophins (NTs) have diverse functions in the nervous system. Their role in the integration of physiological and biochemical aspects of the nervous system is currently attracting much attention. Based on a systematic analysis of the literature, we here propose a new paradigm that, by exploiting a novel role of NTs, may help explai...
Source: Journal of Chemical Neuroanatomy - September 29, 2019 Category: Neuroscience Source Type: research

Neuroprotective effects of docosahexaenoic acid against sub-acute manganese intoxication induced dopaminergic and motor disorders in mice
Publication date: Available online 25 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Radouane El Fari, Abdellatif Abbaoui, Anas Bourziq, Mohamed Zroudi, Ahmed Draoui, Abdelaati El Khiat, Mounir Belkouch, Abdeljalil Elgot, Halima GamraniAbstractManganese (Mn) is an essential metallic trace element involved in several vital biological functions. Conversely, exposure to excessive levels of Mn induces manganism, causing neurodegeneration and symptoms similar to those seen in Parkinson's disease (PD). Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid exhibiting neuroprotective properties ag...
Source: Journal of Chemical Neuroanatomy - September 26, 2019 Category: Neuroscience Source Type: research

Geniposide attenuates neonatal mouse brain injury after hypoxic-ischemia involving the activation of PI3K/Akt signaling pathway
This study aims to investigate whether Geniposide has therapeutic potential to HI brain injury and the underlying mechanisms. C57/bl6 mice were subjected to HI insult on postnatal day 10. Geniposide (20 mg/kg b.w.) was administered intragastrically every day after HI insult for 7 successional days. Then mice at P18 were sacrificed and brain tissues were collected for further analysis. Geniposide treatment significantly inhibited cell apoptosis, reduced serum IgG leakage into brain tissue, attenuated astrogliosis and microgliosis, prevented loss of pericytes, loss of tight junction and adherens junction proteins. The...
Source: Journal of Chemical Neuroanatomy - September 26, 2019 Category: Neuroscience Source Type: research

Special Issue of the Journal of Chemical Neuroanatomy “New methods for studying brain connectivity using viral tracing”
Publication date: Available online 24 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Richard T. Born, Harry W.M. Steinbusch (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - September 25, 2019 Category: Neuroscience Source Type: research

Mobile phone induced cognitive and neurochemical consequences
This study was performed to find out the effect of mobile phone frequency on male Wistar rats. Animals were divided into two groups (n = 6 in each group). Group one was considered as control and group two (experimental group) was exposed to microwave radiation (2100 MHz) for 4 hours/day (5 days/week) for 3 months. Exposure of microwave radiation frequency showed significant alterations in cholinesterase activity, muscular strength, learning ability and anxiety. MWR exposure was also associated with significant alteration in the oxidative defense system and hippocampus degeneration. Histopatholog...
Source: Journal of Chemical Neuroanatomy - September 23, 2019 Category: Neuroscience Source Type: research

The temporal and spatial changes of microtubule cytoskeleton in the CA1 stratum radiatum following global transient ischemia
Publication date: Available online 5 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Tian-Qing Xiong, Chun-Yan Guo, Bai-hong Tan, Yue Gui, Yan-Chao LiAbstractThe down-regulation of microtubule proteins has been widely documented in the ischemic brain, but the temporal or spatial alteration of microtubules has not been systematically investigated in the vulnerable areas after ischemia. By examining the stability and distribution of microtubules following transient global ischemia, we found that the biomarkers of stable microtubules, MAP2 and acetylated α-tubulin, became significantly down-regulated in...
Source: Journal of Chemical Neuroanatomy - September 6, 2019 Category: Neuroscience Source Type: research

Postischemic fish oil treatment restores dendritic integrity and synaptic proteins levels after transient, global cerebral ischemia in rats
Publication date: Available online 6 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Daniela Velasquez de Oliveira, Tuany Caroline Bernardi, Silvana Regina de Melo, Jacqueline Godinho, Rúbia Maria Weffort de Oliveira, Humberto MilaniAbstractWe previously found that fish oil (FO) facilitated memory recovery in the absence of pyramidal neuron rescue after transient, global cerebral ischemia (TGCI). Fish oil preserved the expression of microtubule-associated protein 2 (MAP-2), suggesting a relationship between dendritic plasticity and memory recovery that is mediated by FO after TGCI. The present study...
Source: Journal of Chemical Neuroanatomy - September 6, 2019 Category: Neuroscience Source Type: research

Volumetric investigation of the hippocampus in rat offspring due to diabetes in pregnancy–A stereological study
ConclusionThese data indicate that diabetes during pregnancy has a negative impact on the development of the hippocampus in the rats. These changes in the volume of hippocampal CA1, DG, and subiculum areas might be at the core of underlying neurocognitive and neurobehavioral impairments observed in the children of diabetic mothers. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 31, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: October 2019Source: Journal of Chemical Neuroanatomy, Volume 100Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 28, 2019 Category: Neuroscience Source Type: research

Changes in pyramidal and granular neuron numbers in the rat hippocampus 7 days after exposure to a continuous 900-MHz electromagnetic field during early and mid-adolescence
In conclusion, higher numbers of both pyramidal and granule neurons were found in the male rat hippocampus after continuous 900-MHz EMF treatment. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 27, 2019 Category: Neuroscience Source Type: research

Volumetric Investigation of the Hippocampus in Rat Offspring Due to Diabetes in Pregnancy- A Stereological Study
ConclusionThese data indicate that diabetes during pregnancy has a negative impact on the development of the hippocampus in the rats. These changes in the volume of hippocampal CA1, DG, and subiculum areas might be at the core of underlying neurocognitive and neurobehavioral impairments observed in the children of diabetic mothers. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 21, 2019 Category: Neuroscience Source Type: research

Long noncoding RNA NORAD regulates MPP+-induced Parkinson’s disease model cells
ConclusionWe presented a novel functional role of lncRNA NORAD in regulating human Parkinson’s disease. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 15, 2019 Category: Neuroscience Source Type: research

Regulation of adult hippocampal neurogenesis exerted by sexual, cognitive and physical activity: An update
Publication date: Available online 14 August 2019Source: Journal of Chemical NeuroanatomyAuthor(s): P. Leal-Galicia, H. Romo-Parra, L.M. Rodríguez-Serrano, M. Buenrostro-JáureguiAbstractIn 1962, Joseph Altman described that the brain generates neurons after the postnatal period, and this continues throughout your life (Altman, 1962). This was a breakthrough in the neuroscience field because before this the accepted paradigm was that the brain only generated neurons during the embryonal development. This discovery has been controversial ever since, especially since one of the areas of the brain with neurogenic...
Source: Journal of Chemical Neuroanatomy - August 14, 2019 Category: Neuroscience Source Type: research

Response of distant regions affected by diaschisis commissuralis in one of the most common models of transient focal ischemia in rats
In conclusion, transient focal ischemia affects remote regions of the brain and initiates processes involved in neuronal degeneration in an order which corresponds to the tissue sensitivity to ischemia, namely earlier in the contra-penumbra, and afterwards in the contra-core. The mechanism of secondary damage would influence the progressive neuronal loss of more distant brain regions. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 13, 2019 Category: Neuroscience Source Type: research

Monosynaptic tracing: a step-by-step protocol
Publication date: Available online 10 August 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Thomas K. Lavin, Lei Jin, Ian R. WickershamAbstractMonosynaptic tracing using deletion-mutant rabies virus allows whole-brain mapping of neurons that are directly presynaptic to a targeted population of neurons. The most common and robust way of implementing it is to use Cre mouse lines in combination with Cre-dependent adeno-associated viral vectors for expression of the required genes in the targeted neurons before subsequent injection of the rabies virus. Here we present a step-by-step protocol for performing such experim...
Source: Journal of Chemical Neuroanatomy - August 12, 2019 Category: Neuroscience Source Type: research

Phenotyping neurons activated in the mouse brain during restoration of salt debt
Publication date: Available online 6 August 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Craig M Smith, Joshua Cross, Izel M Eraslan, Aparna Attawar, Sarah Ch’ng, Poshmaal Dhar, Rasika Samarasinghe, Laura Gray, Andrew J LawrenceAbstractSalt overconsumption contributes to hypertension, which is a major risk factor for stroke, heart and kidney disease. Characterising neuronal pathways that may control salt consumption is therefore important for developing novel approaches for reducing salt overconsumption. Here, we identify neurons within the mouse central amygdala (CeA), lateral parabrachial nucleus (LPBN), ...
Source: Journal of Chemical Neuroanatomy - August 8, 2019 Category: Neuroscience Source Type: research

Spatial and temporal immunoreactivity in the rat brain using an affinity purified polyclonal antibody to DNSP-11
Publication date: Available online 5 August 2019Source: Journal of Chemical NeuroanatomyAuthor(s): James W.H. Sonne, Jason S. Groshong, Corey Seavey, Don M. GashAbstractDNSP-11 antibody signal was investigated in perfusion fixated Fischer 344 rat brains by immunohistochemistry with a custom, affinity purified polyclonal antibody. The DNSP-11-antibody signal was differentially localized from the mature GDNF protein both spatially and temporally. In the mesencephalon of post-natal day 10 animals, when GDNF is maximally expressed, DNSP-11 and GDNF antibody immunoreactivities co-localize extensively but not exclusively. In adu...
Source: Journal of Chemical Neuroanatomy - August 6, 2019 Category: Neuroscience Source Type: research

Pro-apoptotic cell signaling in the prefrontal cortex contributes to depressive-/anxiogenic-like behavioral phenotype of mice subchronically exposed to dexamethasone
Publication date: Available online 30 July 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Suélen Osório Heck, Vanessa Angonesi Zborowski, Simone Pinton, Cristina Wayne NogueiraAbstractAnimal models have been used to investigate the depressive-/anxiogenic-like phenotype induced by synthetic glucocorticoids (GCs). The aim of the present study was to evaluate if apoptosis in the mouse prefrontal cortex (PFC) contributes to the depressive-/anxiogenic-like behavioral phenotype induced by dexamethasone (DEX) subchronic exposure. In the present study, adult male Swiss mice were exposed to DEX (2 mg/kg...
Source: Journal of Chemical Neuroanatomy - July 31, 2019 Category: Neuroscience Source Type: research

Evaluation of retrograde labeling profiles of HSV1 H129 anterograde tracer
Publication date: Available online 23 July 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Peng Su, Huadong Wang, Jinjin Xia, Xin Zhong, Liang Hu, Yingli Li, Yanqiu Li, Min Ying, Fuqiang XuAbstractHerpes simplex virus type 1 H129 strain has been widely used as a useful anterograde neuronal circuit tracing tool. However, whether H129 is a rigorous anterograde tracer and undergoes anterograde-only spreading are questions of significant interest. In the present study, we evaluated the retrograde labeling efficiency of H129 using a TK and ICP34.5 dual deleted H129 recombinant (named as H306) which was replication-defici...
Source: Journal of Chemical Neuroanatomy - July 24, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: September 2019Source: Journal of Chemical Neuroanatomy, Volume 99Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - July 6, 2019 Category: Neuroscience Source Type: research

Publisher’s Note: Introducing article numbering to Journal of Chemical Neuroanatomy
Publication date: Available online 2 July 2019Source: Journal of Chemical NeuroanatomyAuthor(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - July 3, 2019 Category: Neuroscience Source Type: research

Nꭃ-nitro-L-arginine methyl model of pre-eclampsia elicits differential IBA1 and EAAT1 expressions in brain
Publication date: Available online 25 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Olayemi Kafilat Ijomone, Philemon Shallie, Thajasvarie NaickerAbstractPre-eclampsia (PE) is a pregnancy syndrome associated with an increased risk of both the mother and the baby developing cardiovascular disorders later in life. It is widely accepted that women with severe PE develop a neurological impairment however studies have revealed that the mother and baby are at jeopardy for a neurological deficit later in life. The present study examined expression of Ionized calcium binding adaptor molecule 1 (IBA1) and Excitatory a...
Source: Journal of Chemical Neuroanatomy - June 26, 2019 Category: Neuroscience Source Type: research

Upregulation of hippocampal synaptophysin, GFAP and mGluR3 in a Pilocarpine rat model of epilepsy with history of prolonged febrile seizure
Publication date: Available online 24 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Oluwole Ojo Alese, Musa V. MabandlaAbstractDespite the increasing interest and efforts to prevent, treat, and control epilepsy and its clinical manifestation (seizure), the prevalence has not decreased due to incomplete understanding of its etiology. The present study aimed at determining the effect of prolonged febrile seizure (PFS) on the onset of seizure in pilocarpine rat model of temporal lobe epilepsy (TLE).After induction of PFS at postnatal day (PND) 14 in ten out of thirty pups, epilepsy was induced with 350 mg...
Source: Journal of Chemical Neuroanatomy - June 26, 2019 Category: Neuroscience Source Type: research

Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field
Publication date: Available online 19 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Ahmad yahyazadeh, Berrin Zuhal AltunkaynakAbstractExposure to electromagnetic field in long-term use of cell phones has increased concerns about serious health problems. Our aim was to survey the possible effects of electromagnetic field radiation (60 min/day for 28 days) on the spinal cords of 12 weeks old rats. Further, we investigated whether the administration of thymoquinone (10 mg/kg/day) would protect the spinal cord tissue against the adverse effects of electromagnetic field or not. Twenty-four adult male...
Source: Journal of Chemical Neuroanatomy - June 20, 2019 Category: Neuroscience Source Type: research

Neuroprotective effect of exogenous melatonin on the noradrenergic neurons of adult male rats’ locus coeruleus nucleus following REM sleep deprivation
Publication date: Available online 17 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Seyed Behnamedin Jameie, Somaye Mesgar, Abbas Aliaghaei, Amir Raoofi, Maryam Amini, Fariba Khodagholi, Samira Danyali, Marziyeh Sorraya, Yousef SadeghiAbstractMelatonin is primarily secreted by the pineal gland in dark. In addition to its role as an internal sleep facilitator, melatonin acts as an antioxidant, anti-inflammatory and neuroprotective agents. melatonin has been introduced as a therapeutic strategy for sleep disorders. Hence, in the present study, we studied the neuroprotective effects of pre- and post-treatment of...
Source: Journal of Chemical Neuroanatomy - June 18, 2019 Category: Neuroscience Source Type: research

A single injection of imipramine affected proliferation in the hippocampus of adult Swiss mice depending on the route of administration, doses, survival time and lodging conditions
Publication date: Available online 13 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Martina Podolan, Juliano dos Santos, Thais Walber, Fernanda Possamai, Giordano Gubert Viola, Cilene Lino de OliveiraAbstractSwiss mice may be valuable for the screening of antidepressants in preclinical trials. Acute treatment with antidepressants may affect the behaviour of Swiss mice, but the effects on their hippocampal neurogenesis remain unknown. The present work aims to assess the influence of acute treatment with antidepressants on cell proliferation in the dentate gyrus of the hippocampus of adult Swiss mice. Cell prol...
Source: Journal of Chemical Neuroanatomy - June 14, 2019 Category: Neuroscience Source Type: research

Method for Labeling and Reconstruction of Single Neurons Using Sindbis Virus Vectors
We describe in detail a protocol for single-neuron labeling using Sindbis virus vectors, and we provide an example of a recent project at our laboratory in which we successfully applied these methods to study thalamocortical projection neurons. Further, we discuss the strengths and limitations of Sindbis virus vectors for single neuron reconstruction, comparing them with adeno-associated virus vectors. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - June 8, 2019 Category: Neuroscience Source Type: research

Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic Aluminum exposure in rat
Publication date: Available online 4 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Wafaa Laabbar, Abdeljalil Elgot, Omar Elhiba, Halima GamraniAbstractAluminum (Al) among the abundant metals on the earth crust, is able to cross the biological barriers via the gastrointestinal and lung tissues. Once in the body, this heavy metal accumulates in different organs, especially the central nervous system. Though its influence is evidently shown in the substantia nigra of Parkinson’s disease patients and other brain areas in other neurodegenerative diseases, few studies have demonstrated that Al could trigger p...
Source: Journal of Chemical Neuroanatomy - June 4, 2019 Category: Neuroscience Source Type: research

DNA sequencing in high-throughput neuroanatomy
Publication date: Available online 4 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Justus M KebschullAbstractMapping brain connectivity at single cell resolution is critical for understanding brain structure. For decades, such mapping has been principally approached with microscopy techniques, aiming to visualize neurons and their connections. However, these techniques are very labor intensive and do not scale well to the complexity of mammalian brains. We recently leveraged the speed and parallelization of DNA sequencing to map the projections of thousands of single neurons in single experiments, and to map ...
Source: Journal of Chemical Neuroanatomy - June 4, 2019 Category: Neuroscience Source Type: research

The Effect of Acute Organophosphate Intoxication on Female Rat Hippocampus Cornu Ammonis Region Pyramidal Neuron Numbers, Biochemistry and Morphology
Publication date: Available online 29 May 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Orhan Bas (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 30, 2019 Category: Neuroscience Source Type: research

Noradrenergic terminal density varies among different groups of hypoglossal premotor neurons
Publication date: Available online 22 May 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Caroline E. Boyle, Anjum Parkar, Amanda Barror, Leszek KubinAbstractIn obstructive sleep apnea (OSA) patients, contraction of the muscles of the tongue is needed to protect the upper airway from collapse. During wakefulness, norepinephrine directly excites motoneurons that innervate the tongue and other upper airway muscles but its excitatory effects decline during sleep, thus contributing to OSA. In addition to motoneurons, NE may regulate activity in premotor pathways but little is known about these upstream effects. To start...
Source: Journal of Chemical Neuroanatomy - May 23, 2019 Category: Neuroscience Source Type: research

MicroRNAs expressed in depression and their associated pathways: a systematic review and a bioinformatics analysis
This study review systematically the literature to identify which microRNAs are currently being associated with depression and their related pathways. The electronic search was conducted in PubMed, Scopus, Scielo, ISI Web of Knowledge, and PsycINFO databases, using the search terms “Depressive Disorder” or “Depression” and “MicroRNAs”. After, microRNAs that were up and down-regulated in depression were analyzed by bioinformatics. We observed that among the 77 microRNAs cited by included studies, 54 had their levels altered in depressed individuals compared to controls, 30 being up-regula...
Source: Journal of Chemical Neuroanatomy - May 23, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: July 2019Source: Journal of Chemical Neuroanatomy, Volume 98Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 21, 2019 Category: Neuroscience Source Type: research