Filtered By:
Specialty: Neuroscience
Therapy: Stem Cell Therapy

This page shows you your search results in order of date. This is page number 7.

Order by Relevance | Date

Total 104 results found since Jan 2013.

Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells
Jukka Jolkkonen
Source: Journal of Cerebral Blood Flow and Metabolism - February 27, 2015 Category: Neuroscience Authors: Bhimashankar MitkariErja KerkeläJohanna NystedtMatti KorhonenJukka Jolkkonen Tags: β-amyloid calcium cell therapy cerebral ischemia secondary pathology Source Type: research

Enhanced angiogenesis promoted by human umbilical mesenchymal stem cell transplantation in stroked mouse is Notch1 signaling associated
Publication date: 2 April 2015 Source:Neuroscience, Volume 290 Author(s): J. Zhu , Q. Liu , Y. Jiang , L. Wu , G. Xu , X. Liu Cellular therapy has provided hope for restoring neurological function post stroke through promoting endogenous neurogenesis, angiogenesis and synaptogenesis. The current study was based on the observation that transplantation of human umbilical cord mesenchymal stem cells (hUCMSCs) promoted the neurological function improvement in stroked mice and meanwhile enhanced angiogenesis in the stroked hemisphere. Grafted hUCMSCs secreted human vascular endothelial growth factor A (VEGF-A). Notch1 signali...
Source: Neuroscience - February 22, 2015 Category: Neuroscience Source Type: research

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke.
Abstract Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-ba...
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Tang YH, Ma YY, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression.
CONCLUSION: TREK-1 plays an important role in the therapeutic effects of the SSRI escitalopram in PSD model, making TREK-1 an attractive candidate molecule for further understanding the pathophysiology and treatment of PSD. PMID: 25675906 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Lin DH, Zhang XR, Ye DQ, Xi GJ, Hui JJ, Liu SS, Li LJ, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Comparison of the effects of human dental pulp stem cells and human bone marrow‐derived mesenchymal stem cells on ischemic human astrocytes in vitro
This study assesses the cytoprotective effects of human dental pulp stem cells (hDPSCs) and conditioned medium from hDPSCs (CM‐hDPSCs) on ischemic human astrocytes (hAs) in vitro compared with human bone marrow‐derived mesenchymal stem cells (hMSCs). Ischemia of hAs was induced by oxygen–glucose deprivation (OGD). CM‐hDPSCs and hMSCs were collected after 48 hr of culture. Cell death was determined by 3‐[4,5‐dimethylthialzol‐2‐yl]‐2,5‐diphenyltetrazolium bromide and cellular ATP assays. The expression of glial fibrillary acidic protein (GFAP) and musashi‐1 as markers of reactive astrogliosis was examin...
Source: Journal of Neuroscience Research - February 7, 2015 Category: Neuroscience Authors: Miyeoun Song, Seong‐Suk Jue, Young‐Ah Cho, Eun‐Cheol Kim Tags: Research Article Source Type: research

Neuroprotection by human umbilical cord blood-derived progenitors in ischemic brain injuries.
Authors: Arien-Zakay H, Lecht S, Nagler A, Lazarovici P Abstract Stem cells have an extremely high potential to treat many devastating diseases, including neuronal injuries. Albeit the need for human neuronal stem cells, their quantities are very limited by relying on early human embryos as the main source. Therefore, progenitors of other origins, such as human umbilical cord blood (CB) are being considered. In the last decade, various populations isolated from the CB were reported to differentiate in vitro towards a neural phenotype. The conditions to induce the cell differentiation are not conclusive and may incl...
Source: Archives Italiennes de Biologie - November 25, 2014 Category: Neuroscience Tags: Arch Ital Biol Source Type: research

Gender-Linked Stem Cell Alterations in Stroke and Postpartum Depression.
Abstract Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a comorbidity factor of stroke, plays a key role in regenerative medicine, in particular stem cell therapy. We hypothesize that gender is a key factor in culture-induced stemness of adult stem cells. Our goal is to provide new evidence supporting gender effects on stroke and stem cells for the pur...
Source: CNS Neuroscience and Therapeutics - November 15, 2014 Category: Neuroscience Authors: Pabón MM, Ji XM, Fernandez JW, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

The Dance Between The Immune System and Stem Cells
We named it the  immunoLinkTM We have been testing a growing number of Clients with our Quantibody Arrays. Many of of these clients have Autoimmune Disorder Diseases. These range from Rheumatoid Arthritis to Multiple Sclerosis.These arrays are designed to precisely measure factors or markers (proteins) that are dysregulated by these diseases. We measure the levels of these biomarkers in our Clients' Blood serum. The arrays have also been used to measure the levels of markers in plasma and cell culture supernatants.Based on results, we are finding links between immune system and stem cell health. We call this the ...
Source: Neuromics - September 30, 2014 Category: Neuroscience Tags: autoimmune disease G-CSF GM-CSF Human Mesenchymal Stem Cells immune response immunoLink Neural Progenitor Cells Neural Stem Cell Markers Source Type: news

Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia
Abstract Human umbilical cord blood (HUCB) cells have shown efficacy in rodent models of focal ischemia and in vitro systems that recapitulate stroke conditions. One potential mechanism of protection is through secretion of soluble factors that protect neurons and oligodendrocytes (OLs) from oxidative stress. To overcome practical issues with cellular therapies, identification of soluble factors released by HUCB and other stem cells may pave the way for treatment modalities that are safer for a larger percentage of stroke patients. Among these soluble factors is leukemia inhibitory factor (LIF), a cytokine that exerts plei...
Source: European Journal of Neuroscience - July 1, 2014 Category: Neuroscience Authors: Derrick D. Rowe, Lisa A. Collier, Hilary A. Seifert, Cortney B. Chapman, Christopher C. Leonardo, Alison E. Willing, Keith R. Pennypacker Tags: Research Report Source Type: research

Neural stem and progenitor cells in the aged subependyma are activated by the young niche
Abstract: Previous studies have demonstrated an age related decline in the size of the neural stem cell (NSC) pool and a decrease in neural progenitor cell proliferation, however, the mechanisms underlying these changes are unclear. In contrast to previous reports, we report that the numbers of NSCs is unchanged in the old age subependyma and the apparent loss is because of reduced proliferative potential in the aged stem cell niche. Transplantation studies reveal that the proliferation kinetics and migratory behavior of neural precursor cells are dependent on the age of the host animal and independent of the age of the do...
Source: Neurobiology of Aging - January 31, 2014 Category: Neuroscience Authors: David Piccin, Adele Tufford, Cindi M. Morshead Tags: Regular Articles Source Type: research

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke.
CONCLUSIONS: Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation. PMID: 24393245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, Zhuge QC, Xie LK, Wang B, Su DM, Jin KL Tags: CNS Neurosci Ther Source Type: research

Gypenosides pre-treatment protects the brain against cerebral ischemia and increases neural stem cells/progenitors in the subventricular zone.
Abstract Gypenosides (GPs) have been reported to have neuroprotective effects in addition to other bioactivities. The protective activity of GPs during stroke and their effects on neural stem cells (NSCs) in the ischemic brain have not been fully elucidated. Here, we test the effects of GPs during stroke and on the NSCs within the subventricular zone (SVZ) of middle cerebral artery occlusion (MCAO) rats. Our results show that pre-treatment with GPs can reduce infarct volume and improve motor function following MCAO. Pre-treatment with GPs significantly increased the number of BrdU-positive cells in the ipsilateral...
Source: International Journal of Developmental Neuroscience - December 12, 2013 Category: Neuroscience Authors: Wang XJ, Sun T, Kong L, Shang ZH, Yang KQ, Zhang QY, Jing FM, Dong L, Xu XF, Liu JX, Xin H, Chen ZY Tags: Int J Dev Neurosci Source Type: research

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation.
CONCLUSION: Our results indicate that PFT-α enhances the survival of grafted NSCs through the inhibition of p53 translocation into the nucleus. PMID: 23253187 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Lei XH, Zhao D, Li YL, Li XF, Sun X, Du WZ, Sun Y, Hao ZF, Xin SY, Liu C, Zhang ZR, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research