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Specialty: Neuroscience
Therapy: Stem Cell Therapy
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Total 104 results found since Jan 2013.
Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice
CONCLUSION: The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke.PMID:37592866 | DOI:10.1111/cns.14412
Source: CNS Neuroscience and Therapeutics - August 18, 2023 Category: Neuroscience Authors: Yu Yang Qianqian Liu Song Deng Qian Shao Long Peng Yuejuan Ling Yue Huang Siqi Zheng Qiaoji Jiang Dekang Nie Jian Chen Source Type: research
MiR-199a-5p enhances neuronal differentiation of neural stem cells and promotes neurogenesis by targeting Cav-1 after cerebral ischemia
CONCLUSION: MiR-199a-5p may target and inhibit Cav-1 to enhance neurogenesis and thus promote functional recovery after cerebral ischemia. These findings indicate that miR-199a-5p is a promising target for the treatment of ischemic stroke.PMID:37349971 | DOI:10.1111/cns.14323
Source: CNS Neuroscience and Therapeutics - June 23, 2023 Category: Neuroscience Authors: Hua-Qian Jin Wei-Feng Jiang Xin-Tian Zheng Lin Li Yan Fang Yan Yang Xiao-Wei Hu Li-Sheng Chu Source Type: research
Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia
CONCLUSIONS: Fibrinogen deposition inhibits remyelination after ischemic damage and NSC-derived exosomal miR-128-3p promotes OPC differentiation into OLs by suppressing BMP signaling, indicating that NSC-derived exosomal miR-128-3p represents a potential therapeutic target for ischemic stroke.PMID:36756722 | DOI:10.1111/cns.14113
Source: CNS Neuroscience and Therapeutics - February 9, 2023 Category: Neuroscience Authors: Huiqing Hou Yafei Wang Lan Yang Yongjun Wang Source Type: research
Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD/R-Treated Microglia via the GPR30-TLR4-NF- κB Axis
Neurochem Res. 2023 Jan 30. doi: 10.1007/s11064-023-03866-3. Online ahead of print.ABSTRACTIschemic stroke (IS) is the most common type of stroke and the second leading cause of death overall. Neural stem cells play protective roles in IS, but the underlying mechanism remains to be determined. Neural stem cells (NSC) were obtained from the fetal brain tissue of C57BL/6J mice. NSC-derived exosomes (NSC-Exos) were identified in the conditioned medium. Internalization of NSC-Exos was analyzed by fluorescence microscopy. In vitro microglia ischemic stroke injury model was induced using oxygen glucose deprivation/re-oxygenation...
Source: Neurochemical Research - January 30, 2023 Category: Neuroscience Authors: Jun Peng Zhengtao Yu Rongjun Xiao Xiqi Hu Ying Xia Source Type: research
Neuroprotective Effects of Conditioned Medium of Mesenchymal Stem Cells (MSC-CM) as a Therapy for Ischemic Stroke Recovery: A Systematic Review
Neurochem Res. 2022 Dec 30. doi: 10.1007/s11064-022-03848-x. Online ahead of print.ABSTRACTIt has been reported that the therapeutic potential of stem cells is mainly mediated by their paracrine factors. In order to identify the effects of conditioned medium of mesenchymal stem cells (MSC-CM) against stroke, a systematic review was conducted. We searched PubMed, Scopus, and ISI Web of Science databases for all available articles relevant to the effects of MSC-CM against the middle cerebral artery occlusion (MCAO) model of ischemic stroke until August 2022. The quality of the included studies was evaluated using The STAIR s...
Source: Neurochemical Research - December 29, 2022 Category: Neuroscience Authors: Mahin Behzadifard Nahid Aboutaleb Mojtaba Dolatshahi Maryam Khorramizadeh Hamzeh Mirshekari Jahangiri Zeynab Kord Donya Nazarinia Source Type: research
Therapeutic potential of hair follicle-derived stem cell intranasal transplantation in a rat model of ischemic stroke
Stem cell-based therapy has received considerable attention as a potential candidate in the treatment of ischemic stroke; however, employing an appropriate type of stem cells and an effective delivery route ar...
Source: BMC Neuroscience - July 25, 2022 Category: Neuroscience Authors: Seyedeh Maryam Mousavi, Bijan Akbarpour, Saeideh Karimi-Haghighi, Sareh Pandamooz, Ivaldo Jesus Almeida Bel ém-Filho, Marianella Masís-Calvo, Haniye Salimi, Ramin Lashanizadegan, Alireza Pouramini, Maryam Owjfard, Etrat Hooshmandi, Mahnaz Bayat, Seyedeh Tags: Research Source Type: research
Hippocampal neuroprotection mediated by secretome of human mesenchymal stem cells against experimental stroke
CONCLUSION: Our results suggest that hESC-MSC-CM could promote neurogenesis and protect brain tissue from ischemic injury, partly mediated by induction of angiogenesis and neurotrophic factors and inhibition of inflammatory and apoptotic factors expression.PMID:35715988 | DOI:10.1111/cns.13886
Source: CNS Neuroscience and Therapeutics - June 18, 2022 Category: Neuroscience Authors: Afsaneh Asgari Taei Leila Dargahi Pariya Khodabakhsh Mehdi Kadivar Maryam Farahmandfar Source Type: research
