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Therapy: Antibiotic Therapy
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Total 89 results found since Jan 2013.
New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2015 Category: Hematology Authors: J. Hawiger, R. A Veach, J. Zienkiewicz Tags: Review Article Source Type: research
Neurologic Complications of Osler-Weber-Rendu Syndrome: A Case Report and Literature Review (P3.058)
CONCLUSIONS: Brain abscess or ischemic stroke must be expected in patients with history of OWRS who present with neurologic manifestations. Family members of such patients should be screened for OWRS with appropriate genetic testing. All the patients with OWRS, whether symptomatic or not, should be screened for pulmonary AVMs. If found, pulmonary AVM’s should be treated to prevent paradoxical embolism which can result in brain abscess or ischemic stroke, both of which can be potentially fatal. Endovascular embolization is the treatment of choice for pulmonary AVMS and a long term follow-up is recommended after the pr...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Farooq, S., Mowla, A., AbdelRazek, M., Iqbal, A., Sawyer, R. Tags: Headache II Source Type: research
Aspiration Pneumonia in the Geriatric Population
Abstract
Aspiration pneumonia is a common infection in older adults and has a high mortality rate. Oropharyngeal dysphagia is the major mechanism leading to aspiration pneumonia in the older adult. Many conditions that are prevalent in the older adult population such as stroke, parkinsonism, dementia, and institutionalization have an increased incidence of oropharyngeal dysphagia. Aspiration pneumonia is a bacterial pulmonary infection which is dependent upon the amount of bacterial inoculum, the virulence of the organism, and the host immune system. It is treated with antibiotic therapy that is similar to therapi...
Source: Current Geriatrics Reports - March 31, 2015 Category: Geriatrics Source Type: research
The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial
Publication date: Available online 20 January 2015 Source:The Lancet Author(s): Willeke F Westendorp , Jan-Dirk Vermeij , Elles Zock , Imke J Hooijenga , Nyika D Kruyt , Hans J L W Bosboom , Vincent I H Kwa , Martijn Weisfelt , Michel J M Remmers , Robert ten Houten , A H C M (Tobien) Schreuder , Sarah E Vermeer , Ewout J van Dijk , Diederik W J Dippel , Marcel G W Dijkgraaf , Lodewijk Spanjaard , Marinus Vermeulen , Tom van der Poll , Jan M Prins , Frederique H Vermeij , Yvo B W E M Roos , Ruud P Kleyweg , Henk Kerkhoff , Matthijs C Brouwer , Aeilko H Zwinderman , Diederik van de Beek , Paul J Nederkoorn Background In a...
Source: The Lancet - January 21, 2015 Category: Journals (General) Source Type: research
Preventive antibiotic therapy in stroke: PASSed away?
Publication date: Available online 20 January 2015 Source:The Lancet Author(s): Andreas Meisel
Source: The Lancet - January 21, 2015 Category: Journals (General) Source Type: research
Comment Preventive antibiotic therapy in stroke: PASSed away?
Stroke not only impairs neurological function but also leads to severe medical complications,1 of which infections, especially pneumonia, are the most important.2 In the past 10 years, epidemiological data have consistently shown that post-stroke infections are associated with increased mortality and poor neurological outcomes.3–5 Dysphagia and a stroke-induced immunodepressive state are risk factors for post-stroke infections.6 Despite general measures for infection prevention, pneumonia remains a common and severe clinical challenge, even for patients treated in specialised stroke units5,7 that are known to reduce the ...
Source: LANCET - January 20, 2015 Category: Journals (General) Authors: Andreas Meisel Tags: Comment Source Type: research
Medical management of abdominal aortic aneurysms.
Abstract
Abdominal aortic aneurysms (AAA) are the most common arterial aneurysms. Endovascular or open surgical aneurysm repair is indicated in patients with large AAA ≥ 5.5 cm in diameter as this prevents aneurysm rupture. The presence even of small AAAs not in need of immediate repair is associated with a very high cardiovascular risk including myocardial infarction, stroke or cardiovascular death. This risk by far exceeds the risk of aneurysm rupture. These patients therefore should be considered as high-risk patients and receive optimal medical treatment and life-style modificiation of their cardiovascular r...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 27, 2014 Category: Surgery Authors: Weiss N, Rodionov RN, Mahlmann A Tags: Vasa Source Type: research
Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan
Conclusions:
The data from PASS will establish whether preventive antibiotic therapy in acute stroke improves functional outcome by preventing infection and will be analyzed according to this pre-specified SAP.Trial registration: Current controlled trials; ISRCTN66140176. Date of registration: 6 April 2010.
Source: Trials - October 1, 2014 Category: Journals (General) Authors: Willeke WestendorpJan-Dirk VermeijDiederik DippelMarcel DijkgraafTom van der PollJan PrinsFrederique VermeijYvo RoosMatthijs BrouwerAeilko ZwindermanDiederik van de BeekPaul Nederkoorn Source Type: research
Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial
Conclusion:
The data from PASS will establish whether preventive antibiotic therapy in acute stroke improves functional outcome by preventing infection. In this update, we changed our primary outcome analysis from dichotomisation to ordinal regression analysis.Trial registration: Current controlled trials; ISRCTN66140176. Date of registration: 6 April 2010.
Source: Epidemiologic Perspectives and Innovations - April 21, 2014 Category: Epidemiology Authors: Willeke F WestendorpJan-Dirk VermeijNan van GelovenDiederik WJ DippelMarcel GW DijkgraafTom van der PollJan M PrinsLodewijk SpanjaardFrederique H VermeijPaul J NederkoornDiederik van de Beek Source Type: research
Compartmentalization of Immune Responses during Staphylococcus aureus Cranial Bone Flap Infection.
Abstract
Decompressive craniectomy is often required after head trauma, stroke, or cranial bleeding to control subsequent brain swelling and prevent death. The infection rate after cranial bone flap replacement ranges from 0.8% to 15%, with an alarming frequency caused by methicillin-resistant Staphylococcus aureus, which is problematic because of its recalcitrance to antibiotic therapy. Herein we report the establishment of a novel mouse model of S. aureus cranial bone flap infection that mimics several aspects of human disease. Bacteria colonized bone flaps for up to 4 months after infection, as revealed by scan...
Source: The American Journal of Pathology - June 6, 2013 Category: Pathology Authors: Cheatle J, Aldrich A, Thorell WE, Boska MD, Kielian T Tags: Am J Pathol Source Type: research
Kocuria kristinae endocarditis related to diabetic foot infection.
We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 °C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confir...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Citro R, Prota C, Greco L, Mirra M, Masullo A, Silverio A, Bossone E, Piscione F Tags: J Med Microbiol Source Type: research
‘A clear case of chronic aspiration of starch (potato)’
In June 2011 a 74 years old‐non smoker woman came to our attention complaining for months dyspnea and dry cough resistant to nonspecific antibiotic therapy (amoxicillin/clavulanic acid and levofloxacin, prescribed by her physician, for 10 days). She had no history of respiratory diseases; she had instead history of cerebri stroke (in March 2006), without neurological outcome, and throat cancer treated with radiotherapy 10 years before. When she came to our attention, physical examination showed dry crackles bilaterally in the lower lung fields. Pulmonary function test showed a mild restrictive respiratory pattern while t...
Source: The Clinical Respiratory Journal - April 11, 2013 Category: Respiratory Medicine Authors: A. Andreani, G. Cappiello, M. Valli, E. Businarolo, R. Melara, M. Giovannini, G. Rossi Tags: Forum Source Type: research
Early blood-based microbiological testing is ineffective in severe stroke patients
Conclusions: Very early bacteremia seems not to be a feature of severe stroke in patients despite signs of early immune system depression and frequent subsequent evidence of infection including pneumonia. Consequently our data suggests, that routine early blood-based standard or molecular microbiological assays do not reveal bacteremia, this finding questions the usefulness of their routine performance in this context.
Source: Journal of the Neurological Sciences - January 28, 2013 Category: Neurology Authors: Christoph Gumbinger, Andreas Hug, Bettina Mürle, Benjamin Berger, Markus Zorn, Klaus-Peter Becker, Stefan Zimmermann, Alexander H. Dalpke, Roland Veltkamp Tags: Original Articles Source Type: research
Fulminant Cerebral Infarction of Anterior and Posterior Cerebral Circulation after Ascending Type of Facial Necrotizing Fasciitis
Necrotizing fasciitis is a soft tissue infection that is characterized by extensive necrosis of the subcutaneous fat, neurovascular structures, and fascia. Cerebral infarction after facial necrotizing fasciitis has been rarely reported. A 61-year-old woman with diabetes was admitted with painful swelling of her right cheek. One day later, she was stuporous and quadriplegic. A computed tomographic scan of her face revealed right facial infection in the periorbital soft tissue, parotid, buccal muscle, and maxillary sinusitis. A computed tomographic scan of the brain revealed cerebral infarction in the right hemisphere, left ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2012 Category: Neurology Authors: Jun Ho Lee, Hui-Chul Choi, Chulho Kim, Jong Hee Sohn, Heung Cheol Kim Tags: Case Reports Source Type: research
