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Therapy: Radiation Therapy

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Total 256 results found since Jan 2013.

Risk of Cerebrovascular Events in Elderly Patients After Radiation Therapy Versus Surgery for Early-Stage Glottic Cancer
Purpose: Comprehensive neck radiation therapy (RT) has been shown to increase cerebrovascular disease (CVD) risk in advanced-stage head-and-neck cancer. We assessed whether more limited neck RT used for early-stage (T1-T2 N0) glottic cancer is associated with increased CVD risk, using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database.Methods and Materials: We identified patients ≥66 years of age with early-stage glottic laryngeal cancer from SEER diagnosed from 1992 to 2007. Patients treated with combined surgery and RT were excluded. Medicare CPT codes for carotid interventions, Medicare IC...
Source: International Journal of Radiation Oncology * Biology * Physics - July 30, 2013 Category: Radiology Authors: Julian C. Hong, Tim J. Kruser, Vinai Gondi, Pranshu Mohindra, Donald M. Cannon, Paul M. Harari, Søren M. Bentzen Tags: Head and Neck Cancers Source Type: research

Branch retinal artery occlusion following radiation therapy to the head and neck: a case report
Conclusion: This case demonstrates that patients receiving radiation to the head and neck may be at increased risk for developing a BRAO secondary to atherosclerotic changes of vessels adjacent to the radiation target. Given this risk, it may be reasonable to obtain carotid artery imaging in patients with a history of cervical radiation who present with sudden or transient visual field defects, even in the absence of other conventional risk factors for atherosclerosis.
Source: BMC Ophthalmology - Latest articles - November 1, 2013 Category: Opthalmology Authors: Helen JiangMaxwell StemJerome Finkelstein Source Type: research

Proton Therapy for Reirradiation of Progressive or Recurrent Chordoma
Conclusions: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional toxicities may develop with longer follow-up times.
Source: International Journal of Radiation Oncology * Biology * Physics - November 23, 2013 Category: Radiology Authors: Mark W. McDonald, Okechuckwu R. Linton, Mitesh V. Shah Tags: Central Nervous System Tumors Source Type: research

Proton therapy for reirradiation of progressive or recurrent chordoma.
CONCLUSIONS: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional toxicities may develop with longer follow-up times. PMID: 24267972 [PubMed - in process]
Source: Health Physics - November 28, 2013 Category: Physics Authors: McDonald MW, Linton OR, Shah MV Tags: Int J Radiat Oncol Biol Phys Source Type: research

Predictors of functional recovery in adults with posterior fossa ependymomas.
Conclusions Greater extent of resection and adjuvant radiotherapy significantly improve PFS in adult patients with posterior fossa ependymomas. Tumor size, cystic changes, and the need for CSF diversion were independent predictors of the rate of functional recovery in this patient population. Taken together, these functional outcome predictors may guide preoperative estimations of recovery following microsurgical resection. PMID: 24579660 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 28, 2014 Category: Neurosurgery Authors: Mirzadeh Z, Bina R, Kusne Y, Coons SW, Spetzler RF, Sanai N Tags: J Neurosurg Source Type: research

Microvascular free tissue reconstruction in the multiply irradiated patient
Conclusion: Microvascular free tissue transfer to the head and neck is expected to provide a successful reconstruction in patients who have received multiple courses of radiation who develop second primary tumors, recurrence of disease, or who suffer from late complications of their radiation therapy.
Source: The Laryngoscope - March 20, 2014 Category: ENT & OMF Authors: Eli A. Gordin, Yadranko Ducic Tags: Original Report Source Type: research

Headaches in brain tumor patients: primary or secondary?
CONCLUSION: Our literature review revealed that brain tumor headache uncommonly presents with classic brain tumor headache characteristics and often satisfies criteria for a primary headache category such as migraine or tension-type. Thus, clinicians may miss headaches due to brain tumors in following ICHD-3 criteria, and the distinction between primary and secondary headache disorders may not be so clear-cut. PMID: 24697234 [PubMed - in process]
Source: Headache - April 1, 2014 Category: Neurology Authors: Nelson S, Taylor LP Tags: Headache Source Type: research

Microvascular free tissue reconstruction in the patient with multiple courses of radiation
ConclusionsMicrovascular free tissue transfer to the head and neck is expected to provide a successful reconstruction in patients who have received multiple courses of radiation and who develop second primary tumors, recurrence of disease, or who suffer from late complications of their radiation therapy. Level of Evidence4. Laryngoscope 124:2252–2256, 2014
Source: The Laryngoscope - May 2, 2014 Category: ENT & OMF Authors: Eli A. Gordin, Yadranko Ducic Tags: Facial Plastics and Reconstructive Surgery Source Type: research

Rt-08 * proton therapy (pt) large-volume re-irradiation for recurrent glioma: overall survival (os) and toxicity outcomes
CONCLUSION: Large-volume PT re-irradiation for recurrent glioma is safe and associated with promising OS outcomes, particularly in the setting of bevacizumab-refractory tumors.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Desai, B., Rockne, R., Rademaker, A., Raizer, J., Paleologos, N., Merrell, R., Grimm, S., Azeem, S., Hartsell, W., Sweeney, P., Swanson, K., Gondi, V. Tags: RADIATION THERAPY (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

In search of a treatment for radiation-induced optic neuropathy
Opinion statement Radiation-induced optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss in one or both eyes within the months to years following radiation therapy. Posterior RON is a rare but devastating toxicity of radiation applied to the visual pathways to treat paranasal sinus and skull base tumors. Anterior RON is an unavoidable consequence of proton beam irradiation or ophthalmic plaque treatment of orbital, choroidal, or retinal tumors. Various treatments aimed at stabilizing and ideally reversing vision loss have been investigated but only in small cases serie...
Source: Current Treatment Options in Neurology - November 8, 2014 Category: Neurology Source Type: research

Phase II trial of hypofractionated intensity-modulated radiation therapy combined with temozolomide and bevacizumab for patients with newly diagnosed glioblastoma
This study demonstrated 90 % 6-month PFS and OS comparable to historic data in patients receiving standard treatment. Bevacizumab did not prevent radiation necrosis associated with this hypofractionated radiation regimen and large PTV volumes may have contributed to high rates of presumed radiation necrosis.
Source: Journal of Neuro-Oncology - December 19, 2014 Category: Cancer & Oncology Source Type: research

Refractory status epilepticus due to SMART syndrome
Conclusions Taking into account clinical evolution and ictal neuroimaging studies, status epilepticus could explain the origin of these episodes in SMART syndrome. Although most patients have reversible symptoms, in some cases, aggressive treatment to avoid sequelae is needed. This article is part of a Special Issue entitled “Status Epilepticus”.
Source: Epilepsy and Behavior - June 12, 2015 Category: Neurology Source Type: research

Refractory status epilepticus due to SMART syndrome.
CONCLUSIONS: Taking into account clinical evolution and ictal neuroimaging studies, status epilepticus could explain the origin of these episodes in SMART syndrome. Although most patients have reversible symptoms, in some cases, aggressive treatment to avoid sequelae is needed. This article is part of a Special Issue entitled "Status Epilepticus". PMID: 26071996 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 11, 2015 Category: Neurology Authors: Jaraba S, Puig O, Miró J, Velasco R, Castañer S, Rodríguez L, Izquierdo C, Simó M, Veciana M, Falip M Tags: Epilepsy Behav Source Type: research

Basic principles and technique of diffusion-weighted imaging and diffusion tensor imaging.
CONCLUSION: Diffusion-weighted MRI is an established technique for the assessment of pathological processes. Although DWI is mainly applied in stroke diagnostics, it is increasingly being used to detect and characterize various lesions in the brain as well as in the whole body. With new sequence techniques imaging artefacts can be significantly reduced. In addition, DTI allows the reconstruction and 3-dimensional visualization of tissue fibre structure. This method has proven to be clinically important primarily for the depiction of nerve tracts in the brain and spinal cord when planning surgical interventions and radiatio...
Source: Der Radiologe - September 2, 2015 Category: Radiology Authors: Backens M Tags: Radiologe Source Type: research

Clinical Reasoning: A 68-year-old man with a history of lung cancer presenting with right-sided weakness and aphasia
A 68-year-old man with paroxysmal atrial fibrillation on warfarin, left subclavian thrombosis treated with carotid-subclavian bypass, and lung adenocarcinoma treated with pneumonectomy, chemotherapy, and prophylactic cranial irradiation and in remission since 1987 was admitted to our neurocritical care unit with acute onset of right-sided weakness, expressive aphasia, and lethargy. On admission his temperature was 101.7°F, and initial blood pressure was 140/60 mm Hg. There was no nuchal rigidity. He was alert and mute with impaired comprehension. He had left gaze preference. Vision was impaired in the right field. Ther...
Source: Neurology - October 5, 2015 Category: Neurology Authors: Gupta, A., Etherton, M. R., McKee, K., Baker, J. M., Izzy, S., Feske, S. K. Tags: All Cerebrovascular disease/Stroke, Radiation therapy-tumor, All Epilepsy/Seizures RESIDENT AND FELLOW SECTION Source Type: research