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Total 99 results found since Jan 2013.

Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke
This study is the first to characterize the gut microbiotic profiles of patients with lacunar or non-lacunar, acute ischemic strokes, and those recovering from stroke, and to identify microbiotic predictors of such strokes.
Source: Frontiers in cellular and infection microbiology - December 21, 2020 Category: Microbiology Source Type: research

Tspan18 is a novel regulator of thrombo-inflammation
AbstractThe interplay between thrombosis and inflammation, termed thrombo-inflammation, causes acute organ damage in diseases such as ischaemic stroke and venous thrombosis. We have recently identified tetraspanin Tspan18 as a novel regulator of thrombo-inflammation. The tetraspanins are a family of 33 membrane proteins in humans that regulate the trafficking, clustering, and membrane diffusion of specific partner proteins. Tspan18 partners with the store-operated Ca2+ entry channel Orai1 on endothelial cells. Orai1 appears to be expressed in all cells and is critical in health and disease. Orai1 mutations cause human immu...
Source: Medical Microbiology and Immunology - May 22, 2020 Category: Microbiology Source Type: research

Simvastatin improves cardiac function through Notch1 activation in BALB/c mice with chronic Chagas cardiomyopathy.
Conclusions and Implications: Simvastatin, probably acting through the Notch1 pathway, decreases inflammation, improving cardiac function in chronically T. cruzi-infected mice. PMID: 32393497 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - May 10, 2020 Category: Microbiology Authors: Guzmán-Rivera D, Liempi A, González-Herrera F, Fuentes S, Carrillo I, Abarca P, Castillo C, Kemmerling U, Pesce B, Maya JD Tags: Antimicrob Agents Chemother Source Type: research

Innovative application of nested PCR for detection of Porphyromonas gingivalis in human highly calcified atherothrombotic plaques.
Authors: Brun A, Rangé H, Prouvost B, Mazighi M, Kapila Y, Bouchard P, Michel JB Abstract Atherothrombosis, leading to stroke and myocardial infarction, is responsible for most of the deaths in the world. An increased risk of atherothrombotic vascular events has been reported in patients with periodontitis. Periodontitis is a chronic multifactorial inflammatory disease, which involves a dysbiotic microbiota, and leads to a progressive destruction of the tooth-supporting apparatus. Transcient periodontal pathogen blood translocation, mainly bacteremia, has been associated with the severity of gingival inflammation....
Source: Journal of Oral Microbiology - May 5, 2020 Category: Microbiology Tags: J Oral Microbiol Source Type: research

Fecal Microbiota Transplantation in Neurological Disorders
Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.
Source: Frontiers in cellular and infection microbiology - March 23, 2020 Category: Microbiology Source Type: research

Re-initiation of Oral Food Intake Following Enteral Nutrition Alters Oral and Gut Microbiota Communities
This study tried to clarify that re-initiating oral food intake could modify the composition of oral/gut microbial communities in patients with dysphagia. From 78 patients with sub-acute stage of stroke, 11 complete tube feeding subjects without taking antibiotics were enrolled and received rehabilitation for re-initiation of oral food intake, and 8 subjects were brought back to complete oral feeding. Oral and gut microbiota community profiles were evaluated using 16S rRNA sequencing of the saliva and feces samples before and after re-initiation of oral food intake in patients recovering from enteral nutrition under the sa...
Source: Frontiers in cellular and infection microbiology - December 19, 2019 Category: Microbiology Source Type: research

The emerging role of gut microbial metabolism on cardiovascular disease.
Abstract The gut microbiome has been implicated in the progression of cardiovascular diseases (CVD) including hypertension, dyslipidemia, atherosclerosis, thrombosis, heart failure, and ischemic stroke. Metabolomics studies in humans and diverse mouse populations have revealed associations between diet-derived gut bacterial metabolites, including trimethylamine-N-oxide, short-chain fatty acids, and intermediates of aromatic amino acid breakdown, with progression of CVD. Functional studies in animals fed diets of defined composition have been instrumental for establishing causal links between these metabolites, the...
Source: Current Opinion in Microbiology - November 2, 2019 Category: Microbiology Authors: Kasahara K, Rey FE Tags: Curr Opin Microbiol Source Type: research

Change of intestinal microbiota in cerebral ischemic stroke patients
Gut microbiota has been suggested to play a role in stroke patients. Nevertheless, little is known about gut microbiota and the clinical indexes in stroke patients.
Source: BMC Microbiology - August 19, 2019 Category: Microbiology Authors: Na Li, Xingcui Wang, Congcong Sun, Xinwei Wu, Mei Lu, Youfeng Si, Xiang Ye, Tan Wang, Xiaolin Yu, Xinjing Zhao, Na Wei and Xingbang Wang Tags: Research article Source Type: research

Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans
This study demonstrated that n-butylphthalide exhibited antifungal activity against Candida albicans with minimum inhibitory concentrations of 128μg/mL and n-butylphthalide combined with fluconazole showed synergistic antifungal effects against resistant Candida albicans, resulting in a decrease in the minimum inhibitory concentrations of fluconazole from>512 to 0.25-1μg/mL. Time-killing curves verified the antifungal activity in dynamic. Besides, n-butylphthalide exhibited anti-biofilm activity against Candida albicans biofilms preformed
Source: Frontiers in Microbiology - July 1, 2019 Category: Microbiology Source Type: research

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis
Conclusion Recent advances in research on HTLV-1 provide better understanding of the molecular pathogenesis and mechanisms of HAM/TSP, and several clinical trials of novel therapies for patients with HAM/TSP have been initiated. However, long-term improvement of motor disability and quality of life still have not been achieved in HAM/TSP patients, and the clinical management remains challenging. Given that HAM/TSP is characterized by activated T-cells in both the periphery and CNS, studies in HAM/TSP will be highly informative for clarifying the pathogenesis of other neuroinflammatory disorders such as multiple sclerosis....
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut
Xiuli Zeng, Xuxuan Gao, Yu Peng, Qiheng Wu, Jiajia Zhu, Chuhong Tan, Genghong Xia, Chao You, Ruoting Xu, Suyue Pan, Hongwei Zhou, Yan He, Jia Yin
Source: Frontiers in cellular and infection microbiology - February 4, 2019 Category: Microbiology Source Type: research

Subdural effusion and ischemic stroke complicating meningococcal meningitis in an adult
Publication date: Available online 22 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chun-Yu Chang, Tsung-Lang Chiu, Pau-Yuan Chang, Chih-Ming Hu, Lih-Shinn Wang
Source: Journal of Microbiology, Immunology and Infection - November 22, 2018 Category: Microbiology Source Type: research

Subdural effusion and ischemic stroke complicating meningococcal meningitis in an adult.
PMID: 30497911 [PubMed - as supplied by publisher]
Source: Journal of Microbiology, Immunology, and Infection - November 22, 2018 Category: Microbiology Authors: Chang CY, Chiu TL, Chang PY, Hu CM, Wang LS Tags: J Microbiol Immunol Infect Source Type: research