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Specialty: Microbiology

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Total 99 results found since Jan 2013.

TAT-HSA-α-MSH fusion protein with extended half-life inhibits tumor necrosis factor-α in brain inflammation of mice.
Abstract Neuroinflammation constitutes a principal process involved in the progression of various central nervous system (CNS) disorders, including Parkinson's disease, Alzheimer's disease, ischemic stroke, and traumatic brain injury. The safety and efficacy of potential neuroprotective therapeutic agents is controversial and limited. Alpha-melanocyte-stimulating hormone (α-MSH) as a tridecapeptide derived from pro-opiomelanocortin displays potent anti-inflammatory and protective effects with a wide therapeutic window in brain damage. However, it is difficult to deliver effective concentrations of α-MSH into bra...
Source: Applied Microbiology and Biotechnology - January 27, 2016 Category: Microbiology Authors: Wang M, Zhi D, Wang H, Ru Y, Ren H, Wang N, Liu Y, Li Y, Li H Tags: Appl Microbiol Biotechnol Source Type: research

Edible mushrooms: improving human health and promoting quality life.
Authors: Valverde ME, Hernández-Pérez T, Paredes-López O Abstract Mushrooms have been consumed since earliest history; ancient Greeks believed that mushrooms provided strength for warriors in battle, and the Romans perceived them as the "Food of the Gods." For centuries, the Chinese culture has treasured mushrooms as a health food, an "elixir of life." They have been part of the human culture for thousands of years and have considerable interest in the most important civilizations in history because of their sensory characteristics; they have been recognized for their attractive culinary attributes. Nowadays, mu...
Source: International Journal of Microbiology - February 17, 2015 Category: Microbiology Tags: Int J Microbiol Source Type: research

Increased risk of dementia among chronic osteomyelitis patients
This study investigates whether COM increases the risk of dementia. Taiwanese National Health Insurance (NHI) inpatient claims were used to identify 17,238 patients newly diagnosed with COM from 2000 to 2008, and 68,944 age- and gender-matched patients without COM were randomly selected for comparison. Risks of dementia associated with COM and comorbidities, including hypertension, diabetes, stroke, hyperlipidemia, and depression, were evaluated using data from the end of 2011. Dementia risk was 1.6-fold higher (95 % confidence interval [CI]: 1.4–1.83) in the COM cohort than in the control group, calculated using the mu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 1, 2015 Category: Microbiology Source Type: research

Stroke in patients with tuberculous meningitis in a low TB endemic country: an increasing medical emergency?
This study evaluated the frequency, clinical characteristics, risk factors and outcomes of patients with TBM complicated by stroke admitted to the Infectious Disease Clinic, University of Perugia Hospital, Italy from 1971 to 2010. Over four decades, 419 patients were admitted with tuberculosis, of these 30 (7.1%) were diagnosed with TBM: 20 definite, one probable and nine possible. Twenty-six were evaluable for stroke and six (23%) had stroke. The latter six had advanced stages of meningitis, two tested HIV positive, three HIV negative and in one HIV was not performed. Of seven patients without stroke tested for HIV, only ...
Source: New Microbiologica - December 1, 2014 Category: Microbiology Tags: New Microbiol Source Type: research

Periodontal Innate Immune Mechanisms Relevant to Atherosclerosis
This article is protected by copyright. All rights reserved.
Source: Oral Microbiology and Immunology - October 1, 2014 Category: Microbiology Authors: Salomon Amar, Marianne Engelke Tags: Original Article Source Type: research

Amino acid supplementation enhances urokinase production by HT-1080 cells.
We describe here medium optimization for maximizing urokinase production by HT-1080 cells using supplementation of specific amino acids. The new specifically designed method resulted in 240 % increase in urokinase productivity. PMID: 24671568 [PubMed - as supplied by publisher]
Source: Journal of Industrial Microbiology and Biotechnology - March 27, 2014 Category: Microbiology Authors: Khaparde SS, Roychoudhury PK Tags: J Ind Microbiol Biotechnol Source Type: research

Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis
Background: Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA. Methods: A total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA le...
Source: Annals of Clinical Microbiology and Antimicrobials - March 26, 2014 Category: Microbiology Authors: Mahmut SunnetciogluZafer MengelogluAli BaranMustafa KarahocagilMehmet TosunAbdulkadir KucukbayrakMehmet CeylanHayrettin AkdenizCenk Aypak Source Type: research

Kocuria kristinae endocarditis related to diabetic foot infection.
We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 °C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confir...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Citro R, Prota C, Greco L, Mirra M, Masullo A, Silverio A, Bossone E, Piscione F Tags: J Med Microbiol Source Type: research

The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis
Conclusions: The Mtb mutant DeltakstD strain, which is unable to use cholesterol as a source of carbon and energy, has a limited ability to multiply in resting M[latin capital letter o with stroke] following infection, reflecting a failure of the DeltakstD strain to inhibit the TLR2-dependent bactericidal activity of resting M[latin capital letter o with stroke].
Source: BMC Microbiology - Latest articles - February 20, 2013 Category: Microbiology Authors: Marta BrzezinskaIzabela SzulcAnna BrzostekMagdalena KlinkMichal KielbikZofia SulowskaJakub PawelczykJaroslaw Dziadek Source Type: research