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Specialty: Cardiology
Condition: Cholesterol
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Total 2240 results found since Jan 2013.
Statins Tied to Lower Stroke Risk in Atrial Fibrillation Statins Tied to Lower Stroke Risk in Atrial Fibrillation
Initiation of statins soon after diagnosis of AF is associated with lower risk of ischemic and hemorrhagic strokes; longer-term use is tied to further benefit, a new study shows.Medscape Medical News
Source: Medscape Cardiology Headlines - April 28, 2023 Category: Cardiology Tags: Cardiology News Source Type: news
Understanding the molecular mechanisms of statin pleiotropic effects
Arch Toxicol. 2023 Apr 21. doi: 10.1007/s00204-023-03492-6. Online ahead of print.ABSTRACTStatins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic cardiovascular disease. These medications not only reduce low-density lipoprotein cholesterol (LDL-C) via inhibition of 3-hydroxy-3-methylglutarate attached to CoA reductase, the key rate-limiting step in the cholesterol biosynthetic pathway, but also upregulate expression of the low-density lipoprotein receptor, improving serum clearance. Given LDL-C is a causal risk factor for the development of atherosclerosis, these complementary mechanisms ...
Source: Atherosclerosis - April 21, 2023 Category: Cardiology Authors: Charles A German James K Liao Source Type: research
Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction
Front Pharmacol. 2023 Mar 31;14:1151244. doi: 10.3389/fphar.2023.1151244. eCollection 2023.ABSTRACTElevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition characterized by impaired nitric oxide production and decreased vasodilatory capacity. Endothelial dysfunction can promote vascular disease, such as atherosclerosis, where macrophages accumulate in the vascular intima and fatty plaques form that impair normal blood flow in conduit arteries. Current pharmacological strategies to treat atherosclerosis mostly focus on lipid lowering to prevent high levels of plasma cholesterol that induce...
Source: Atherosclerosis - April 17, 2023 Category: Cardiology Authors: O Daniel Vera Heike Wulff Andrew P Braun Source Type: research
Attenuating lipid metabolism in atherosclerosis: The potential role of Anti-oxidative effects on low-density lipoprotein of herbal medicines
Front Pharmacol. 2023 Mar 31;14:1161657. doi: 10.3389/fphar.2023.1161657. eCollection 2023.ABSTRACTAtherosclerosis (AS) is a multifactorial chronic disease with great harm to the health of human being, which is a basic pathogenesis of many cardiovascular diseases and ultimately threatens human life. Abnormal blood lipid level is one of the most common diagnostic indicators of AS in clinic, and lipid metabolism disorder is often observed in patients with AS. Cholesterol is an important lipid in the human body, which is of great significance for maintaining normal life activities. Generally, cholesterol is transported to per...
Source: Atherosclerosis - April 17, 2023 Category: Cardiology Authors: Huxinyue Duan Pan Song Ruolan Li Hong Su Lisha He Source Type: research
Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction
Front Pharmacol. 2023 Mar 31;14:1151244. doi: 10.3389/fphar.2023.1151244. eCollection 2023.ABSTRACTElevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition characterized by impaired nitric oxide production and decreased vasodilatory capacity. Endothelial dysfunction can promote vascular disease, such as atherosclerosis, where macrophages accumulate in the vascular intima and fatty plaques form that impair normal blood flow in conduit arteries. Current pharmacological strategies to treat atherosclerosis mostly focus on lipid lowering to prevent high levels of plasma cholesterol that induce...
Source: Atherosclerosis - April 17, 2023 Category: Cardiology Authors: O Daniel Vera Heike Wulff Andrew P Braun Source Type: research
Attenuating lipid metabolism in atherosclerosis: The potential role of Anti-oxidative effects on low-density lipoprotein of herbal medicines
Front Pharmacol. 2023 Mar 31;14:1161657. doi: 10.3389/fphar.2023.1161657. eCollection 2023.ABSTRACTAtherosclerosis (AS) is a multifactorial chronic disease with great harm to the health of human being, which is a basic pathogenesis of many cardiovascular diseases and ultimately threatens human life. Abnormal blood lipid level is one of the most common diagnostic indicators of AS in clinic, and lipid metabolism disorder is often observed in patients with AS. Cholesterol is an important lipid in the human body, which is of great significance for maintaining normal life activities. Generally, cholesterol is transported to per...
Source: Atherosclerosis - April 17, 2023 Category: Cardiology Authors: Huxinyue Duan Pan Song Ruolan Li Hong Su Lisha He Source Type: research
The effect of intensive statin therapy in non-symptomatic intracranial arteries: The STAMINA-MRI sub-study
CONCLUSION: Intensive statin therapy produced a favorable morphological change in cerebral arteries of not only the target arterial segment but also non-symptomatic arterial segments. The change in cerebral arterial luminal diameter was influenced by the baseline SBP and was dependent on the topographic distribution of the cerebral arteries.Clinical Trial Registration: ClinicalTrials.gov, identifier NCT02458755.PMID:37056360 | PMC:PMC10088516 | DOI:10.3389/fneur.2023.1069502
Source: Atherosclerosis - April 14, 2023 Category: Cardiology Authors: Jae Eun Sim Ha-Na Song Jong-Un Choi Ji-Eun Lee In Young Baek Hwan-Ho Cho Jong-Hoon Kim Jong-Won Chung Gyeong-Moon Kim Hyun-Jin Park Oh Young Bang Woo-Keun Seo Source Type: research
Inflammation Beats Cholesterol: A Comment on the Unequivocal Driver of Cardiovascular Disease Risk
J Clin Med. 2023 Mar 27;12(7):2519. doi: 10.3390/jcm12072519.ABSTRACTDespite advancements in the current standard of care, cardiovascular diseases continue to hold the top spot as the leading cause of mortality worldwide. The development of atherosclerosis is the most common culprit behind ailments such as myocardial infarction, stroke, and peripheral vascular disease. Consequently, it imposes a significant burden on life expectancy, quality of life, morbidity, and societal costs. Both increased cholesterol levels and the activation of the inflammatory cascade are known as cardiovascular risk facts. Their relative weight i...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Mauro Vaccarezza Francesco Maria Galassi Source Type: research
Recurrent Atherosclerotic Cardiovascular Disease Events Potentially Prevented with Guideline-Recommended Cholesterol-Lowering Therapy following Myocardial Infarction
ConclusionImplementation of guideline-recommended cholesterol-lowering therapy could prevent a substantial percentage of recurrent ASCVD events.
Source: Cardiovascular Drugs and Therapy - April 13, 2023 Category: Cardiology Source Type: research
Correlation and predictive value of platelet biological indicators and recurrence of large-artery atherosclerosis type of ischemic stroke
This study confirmed that PAg-ADP, PAg-COL, and FIB are closely related to the formation of LAA-IS due to carotid atherosclerosis, and the combined PAg-ADP, PAg-COL, and FIB index levels are the most promising for assessing the prognostic development of recurrence in patients with LAA-IS. Combined monitoring of platelet aggregation rate and FIB index is of important evaluation value in judging the recurrence prognosis of LAA-IS patients.PMID:37038758 | DOI:10.1080/02648725.2023.2196879
Source: Atherosclerosis - April 11, 2023 Category: Cardiology Authors: Min Zhan Lin-Juan Sun Ye-Hao Zhang Jia-Ming Gao Jian-Xun Liu Source Type: research
The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials
Conclusion: Based on this meta-analysis, we found that in the treatment of T2DM patients with CAS, combined with CHM may have more advantages than WM alone, which can further reduce CIMT and carotid plaque Crouse score, regulate glucose and lipid metabolism, improve insulin resistance and enhance islet β-cell function. Meanwhile, CHM is relatively safe. However, limited by the quality and heterogeneity of included studies, the efficacy and safety of CHM remain uncertain. More high-quality studies are still needed to provide more reliable evidence for the clinical application of CHM. Systematic Review Registration: https:/...
Source: Atherosclerosis - April 10, 2023 Category: Cardiology Authors: Zehua Zhang Yulin Leng Zhengtao Chen Xiaoxu Fu Qingzhi Liang Xi Peng Hongyan Xie Hong Gao Chunguang Xie Source Type: research
