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Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study
ConclusionOur study indicated a significant,non-linear, negative association between plasma selenium and first stroke in males but not in females.Trial registrationChiCTR1800017274.
Source: Biology of Sex Differences - May 29, 2021 Category: Biology Source Type: research

Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin
Free Radic Biol Med. 2021 May 6:S0891-5849(21)00283-5. doi: 10.1016/j.freeradbiomed.2021.05.002. Online ahead of print.ABSTRACTFolates (vitamin B9) are essential components of our diet and our gut microbiota. They are omnipresent in our cells and blood. Folates are necessary for DNA synthesis, methylation, and other vital bioprocesses. Folic acid (FA), as the synthetic form of folates, is largely found in supplements and fortified foods. FA and folate drugs are also extensively used as therapeutics. Therefore, we are continuously exposed to the pterin derivatives, and their photo-degradation products, such as 6-formylpteri...
Source: Free Radical Biology and Medicine - May 9, 2021 Category: Biology Authors: Goossens Jean-Fran çois Xavier Thuru Christian Bailly Source Type: research

Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis.
In this study we demonstrated that parenteral administration of vitamin C significantly improved neurological deficits and reduced brain infarction and brain edema by attenuating the transient middle cerebral artery occlusion (tMCAO)-induced nitrosative stress, inflammatory responses, and the resultant disruptions of blood brain barrier and cerebral neuronal apoptosis. These results suggest that parenteral administration of vitamin C has potential as an adjuvant agent with intravenous thrombolysis or endovascular thrombectomy in acute treatment of ischemic stroke. PMID: 32450129 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 21, 2020 Category: Biology Authors: Chang CY, Chen JY, Wu MH, Hu ML Tags: Free Radic Biol Med Source Type: research

α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury
ConclusionOverall, α-TOH inhibits ischemia/reperfusion injury-induced oxidative and inflammatory responses, and ultimately preserves cardiac function. Therefore, our study provides a strong incentive to test vitamin E as an acute therapy in patients suffering a MI.Graphical abstract
Source: Redox Biology - August 7, 2019 Category: Biology Source Type: research

Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia
The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression ofUbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA ofUbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA ofUbiAd1 gene. F...
Source: Bulletin of Experimental Biology and Medicine - May 24, 2018 Category: Biology Source Type: research

Assessment of Gender-Related Differences in Vitamin D levels and Cardiovascular Risk factors in Saudi Patients with Type 2 Diabetes Mellitus
Publication date: Available online 4 April 2017 Source:Saudi Journal of Biological Sciences Author(s): Manal Abudawood, Hajera Tabassum, Sabah Ansar, Khalid Almosa, Samia Sobki, Mir Naiman Ali, Ali Aljohi Diabetes is a major risk factor for cardiovascular disease (CVD) including stroke, coronary heart disease, and peripheral artery disease. It remains a leading cause of mortality throughout the world, affecting both women and men. This investigation was aimed to study gender based differences in cardiovascular risk factors of adult population with diabetes mellitus (T2DM) and to check the correlation between serum HbA1C, ...
Source: Saudi Journal of Biological Sciences - April 5, 2017 Category: Biology Source Type: research

Low levels of two components of vitamin D can help predict risk of heart attack
(Intermountain Medical Center) Low levels of total vitamin D and bioavailable vitamin D can help predict a person's risk of major adverse cardiovascular events such as a heart attack, stroke, heart failure or death, according to a first-of-its-kind study from the Intermountain Medical Center Heart Institute in Salt Lake City.
Source: EurekAlert! - Biology - April 2, 2016 Category: Biology Source Type: news

Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage.
This study was performed by using the characteristic high lethality rate and sepsis-mimic systemic inflammatory response of a murine model of heat stroke to test our hypothesis that supra-physiological doses of ascorbate may have therapeutic use in critical care. We demonstrated that parenteral administration of ascorbate abrogated the lethality and thermoregulatory dysfunction in murine model of heat stroke by attenuating heat stroke-induced accelerated systemic inflammatory, coagulation responses and the resultant multiple organ injury, especially in hypothalamus. Overall, our findings support the hypothesis and notion t...
Source: Free Radical Biology and Medicine - December 15, 2015 Category: Biology Authors: Chang CY, Chen JY, Chen SH, Cheng TJ, Lin MT, Hu ML Tags: Free Radic Biol Med Source Type: research

Microalgae for the prevention of cardiovascular disease and stroke
Publication date: 15 March 2015 Source:Life Sciences, Volume 125 Author(s): Maria Filomena de Jesus Raposo , Alcina Maria Miranda Bernardo de Morais This review focuses on and discusses the primary phytochemicals present in microalgal biomass — carotenoids, phenolic compounds, antioxidant vitamins, sterols, and polyunsaturated fatty acids — and also on the exopolysaccharides, which are produced by some types of microalgae and may play a significant role in the prevention of cardiovascular diseases (CVD) and strokes. We have listed several preclinical trials and clinical studies supporting the health benefits that mos...
Source: Life Sciences - March 4, 2015 Category: Biology Source Type: research

Excessive {alpha}-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke Research Communication
The vitamin E family includes both tocopherols and tocotrienols, where α-tocopherol (αTOC) is the most bioavailable form. Clinical trials testing the therapeutic efficacy of high-dose αTOC against stroke have largely failed or reported negative outcomes when a "more is better" approach to supplementation (>400 IU/d) was used. This work addresses mechanisms by which supraphysiologic αTOC may contribute to stroke-induced brain injury. Ischemic stroke injury and the neuroinflammatory response were studied in tocopherol transfer protein-deficient mice maintained on a diet containing αTOC vitami...
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Khanna, S., Heigel, M., Weist, J., Gnyawali, S., Teplitsky, S., Roy, S., Sen, C. K., Rink, C. Tags: Research Communication Source Type: research

Effects of vitamin E on peroxisome proliferator-activated receptor γ and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia induced atherosclerosis.
Abstract Atherosclerosis and associated cardiovascular complications such as stroke and myocardial infarction are major causes of morbidity and mortality. We have previously reported a significant increase in mRNA levels of the scavenger receptor CD36 in aortae of cholesterol fed rabbits and shown that vitamin E treatment attenuated increased CD36 mRNA expression. In the present study, we further investigated the redox signaling pathways associated with protection against atherogenesis induced by high dietary cholesterol and correlated these with CD36 expression and the effects of vitamin E supplementation in a ra...
Source: Free Radical Biology and Medicine - February 26, 2014 Category: Biology Authors: Bozaykut P, Karademir B, Yazgan B, Sozen E, Siow RC, Mann GE, Ozer NK Tags: Free Radic Biol Med Source Type: research

Can citrus ward off your risk of stroke?
(American Academy of Neurology) Eating foods that contain vitamin C may reduce your risk of the most common type of hemorrhagic stroke, according to a study released today that will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26-May 3, 2014.
Source: EurekAlert! - Biology - February 14, 2014 Category: Biology Source Type: news