Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia

The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression ofUbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA ofUbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA ofUbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10.
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research