• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

A nationwide cohort study comparing the effectiveness of diuretics and calcium channel blockers on top of renin-angiotensin system inhibitors on chronic kidney disease progression and mortality.
It is unknown whether initiating diuretics on top of renin-angiotensin system inhibitors (RASi) is superior to alternative antihypertensive agents such as calcium channel blockers (CCBs) in patients with chronic kidney disease (CKD). For this purpose, we emulated a target trial in the Swedish Renal Registry 2007-2022 that included nephrologist-referred patients with moderate-advanced CKD and treated with RASi, who initiated diuretics or CCB. Using propensity score-weighted cause-specific Cox regression, we compared risks of major adverse kidney events (MAKE; composite of kidney replacement therapy [KRT], experiencing over ...
Source: Kidney International - June 15, 2023 Category: Urology & Nephrology Authors: Anne-Laure Faucon, Edouard L. Fu, B énédicte Stengel, Faizan Mazhar, Marie Evans, Juan-Jesús Carrero Tags: clinical investigation Source Type: research

Targeting TMEM16A-encoded Ca2+-activated Cl − channels: a new paradigm for antihypertensive therapy?
Hypertension is the leading risk factor for the development of heart diseases and stroke. Many hypertensive patients experience undesirable side effects to conventional antihypertensive pharmacotherapy. Cil et  al. documented the antihypertensive profile of a novel molecule, TMinh-23 (2-bromodifluoroacetylamino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid o-tolylamide), in the spontaneously hypertensive rat model of systemic hypertension. They showed that this agent reduces blood pressu re by inhibiting transmembrane member 16A–encoded calcium-activated chloride channels in vascular myocytes from resistance arteries.
Source: Kidney International - July 19, 2021 Category: Urology & Nephrology Authors: Normand Leblanc Tags: Commentary Source Type: research

Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats.
CONCLUSION: Berberine treatment improved short-term memory in hyperlipidemia by increasing neuronal proliferation and inhibiting neuronal apoptosis. Berberine treatment also improved lipid metabolism. PMID: 31795609 [PubMed]
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China.
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - September 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The Renal Molecular Clock: Broken by Aging and Restored by Exercise.
Abstract The mammalian circadian clock governs physiological, endocrine, and metabolic responses coordinated in a 24h rhythmic pattern by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. The SCN also dictates circadian rhythms in peripheral tissues like the kidney. The kidney has several important physiological functions including removing waste and filtering the blood, regulation of: fluid volume, blood osmolarity, blood pressure and calcium metabolism, all of which are under tight control of the molecular/circadian clock. Normal aging has a profound influence on both renal function, central and pe...
Source: Am J Physiol Renal P... - August 27, 2019 Category: Urology & Nephrology Authors: Schmitt EE, Johnson EC, Yusifova M, Bruns DR Tags: Am J Physiol Renal Physiol Source Type: research

Add-On Antihypertensive Medications to Angiotensin-Aldosterone System Blockers in Diabetes: A Comparative Effectiveness Study.
CONCLUSIONS: Compared with thiazide diuretics, calcium channel blockers were associated with a lower risk of significant kidney events and a similar risk of cardiovascular events. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_03_23_CJASNPodcast_18_5_S.mp3. PMID: 29572286 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 23, 2018 Category: Urology & Nephrology Authors: Schroeder EB, Chonchol M, Shetterly SM, Powers JD, Adams JL, Schmittdiel JA, Nichols GA, O'Connor PJ, Steiner JF Tags: Clin J Am Soc Nephrol Source Type: research

Nutrient intake and urinary incontinence in Korean women: A propensity score ‐matched analysis from the Korea National Health and Nutrition Examination Survey data
ConclusionHigh carbohydrate intake seems to be significantly related to female urinary incontinence in the Korean population.
Source: International Journal of Urology - August 28, 2017 Category: Urology & Nephrology Authors: Jun Ho Lee, Hyo Serk Lee Tags: Original Article Source Type: research

Phosphate-Binding Agents in Adults With CKD: A Network Meta-analysis of Randomized Trials
Conclusions There is currently no evidence that phosphate-binder treatment reduces mortality compared to placebo in adults with CKD. It is not clear whether the higher mortality with calcium versus sevelamer reflects whether there is net harm associated with calcium, net benefit with sevelamer, both, or neither. Iron-based binders show evidence of greater phosphate lowering that warrants further examination in randomized trials.
Source: American Journal of Kidney Diseases - July 22, 2016 Category: Urology & Nephrology Source Type: research

Design and baseline characteristics of the LANDMARK study
Conclusions The LANDMARK study will determine whether LC, a non-Ca-based P binder, reduces cardiovascular mortality and morbidity in chronic hemodialysis patients.
Source: Clinical and Experimental Nephrology - July 11, 2016 Category: Urology & Nephrology Source Type: research

Valvular calcification upon initiating dialysis predict the appearance of cardiovascular events in patient evolution.
CONCLUSIONS: The prevalence of VC at the commencement of dialysis is very high and its presence is an independent predictor of event and cardiovascular mortality presentation in the course of follow-up. PMID: 26300509 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - August 25, 2015 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Association Between Kidney Function, Rehabilitation Outcome, and Survival in Older Patients Discharged From Inpatient Rehabilitation
Conclusions eGFR category and Barthel score are independent risk markers for survival in older rehabilitation patients, but advanced CKD does not preclude successful rehabilitation.
Source: American Journal of Kidney Diseases - June 2, 2015 Category: Urology & Nephrology Source Type: research

Subclinical Atherosclerosis Measures for Cardiovascular Prediction in CKD
In conclusion, each measure improved cardiovascular risk prediction in subjects with CKD, with the greatest improvement observed with coronary artery calcium score.
Source: Journal of the American Society of Nephrology : JASN - January 30, 2015 Category: Urology & Nephrology Authors: Matsushita, K., Sang, Y., Ballew, S. H., Shlipak, M., Katz, R., Rosas, S. E., Peralta, C. A., Woodward, M., Kramer, H. J., Jacobs, D. R., Sarnak, M. J., Coresh, J. Tags: Clinical Epidemiology Source Type: research

Cardiovascular disease in chronic kidney disease
Publication date: January–March 2014 Source:Clinical Queries: Nephrology, Volume 3, Issue 1 Author(s): Shivendra Singh Chronic kidney disease (CKD) is emerging health problem with prevalence of approximately 10% in general population. The incidence and prevalence of cardiovascular disease (CVD) is high in CKD patients, approaching >50% in patients in advance CKD. CVD outcomes are worse in presence of CKD suggesting different pathophysiology compared to general population. Patients with CKD are at increased risk of both atherosclerotic and structural heart disease, stroke and peripheral vascular disease. Congesti...
Source: Clinical Queries: Nephrology - November 1, 2014 Category: Urology & Nephrology Source Type: research

Do higher dialysate calcium concentrations increase vascular stiffness in haemodialysis patients as measured by aortic pulse wave velocity?
Background: Haemodialysis patients have an increased prevalence of hypertension and risk of cardiovascular mortality and stroke. Higher dialysate calcium concentrations have been reported to cause both an acute and chronic increase in arterial stiffness. We therefore looked at changes in arterial stiffness in established haemodialysis patients to determine whether there was a threshold effect of dialysate calcium concentration linked to change in arterial stiffness. Methods: We performed pulse wave velocity measurements six months apart in patients dialysing with calcium concentrations of 1.0, 1.25, 1.35 and>=1.5 mmol/l. R...
Source: BMC Nephrology - September 8, 2013 Category: Urology & Nephrology Authors: Evangelia CharitakiAndrew Davenport Source Type: research

Effect of lower sodium intake on health: systematic review and meta-analyses
This is another article that supports the literature for reduction in salt intake for overall population health. This systematic further shows that not only does salt lower blood pressure, but there are no adverse effects on lipids, catecholamine levels of renal function. Furthermore, it is associated with lower risk of stroke and fatal coronary heart disease in adults. : Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis. Systematic Review: Vitamin D and C...
Source: Nephrology Now - July 15, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: General Nephrology Hypertension Source Type: research

Pages: 1  2