The Renal Molecular Clock: Broken by Aging and Restored by Exercise.

The Renal Molecular Clock: Broken by Aging and Restored by Exercise. Am J Physiol Renal Physiol. 2019 Aug 28;: Authors: Schmitt EE, Johnson EC, Yusifova M, Bruns DR Abstract The mammalian circadian clock governs physiological, endocrine, and metabolic responses coordinated in a 24h rhythmic pattern by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. The SCN also dictates circadian rhythms in peripheral tissues like the kidney. The kidney has several important physiological functions including removing waste and filtering the blood, regulation of: fluid volume, blood osmolarity, blood pressure and calcium metabolism, all of which are under tight control of the molecular/circadian clock. Normal aging has a profound influence on both renal function, central and peripheral circadian rhythms, and the sleep-wake cycle. Disrupted circadian rhythms in the kidney as a result of increased age likely contribute to adverse health outcomes such as nocturia, hypertension, and increased risk for: stroke, cardiovascular disease, and end organ failure. Regular physical activity improves circadian misalignment in both young and old mammals, though the precise mechanisms for this protection remain poorly described. Recent advances in the heart and skeletal muscle literature suggest that regular endurance exercise entrains peripheral clocks, and we propose that similar beneficial adaptations may occur in the kidney through regulation of r...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research