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Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative TCD Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

HIV infection does not influence stroke outcomes in HIV-infected patients: A prospective study.
CONCLUSION: HIV infection does not affect in-hospital mortality and functional outcome in stroke patients a part the length of hospital stay. PMID: 30948261 [PubMed - as supplied by publisher]
Source: Revue Neurologique - April 6, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Variability in the use of neuroimaging techniques for diagnosis and follow-up of stroke patients
Publication date: Available online 14 January 2019Source: Neurología (English Edition)Author(s): C. Valcárcel-Nazco, D. Alonso-Modino, F. Montón-Álvarez, R. Sabatel-Hernández, M.S. Pastor-Santoveña, P. Mesa-Blanco, J.C. López-Fernández, P. Serrano-AguilarAbstractIntroduction and objectiveImaging diagnosis is essential for treatment planning in stroke patients. However, use of these techniques varies due to uncertainty about their effectiveness. Our purpose was to describe the use of CT and MRI in stroke and transient ischaemic attack (TIA) over 5 years in hospitals belonging to the Canary Islands Health Service and...
Source: Neurologia - January 15, 2019 Category: Neurology Source Type: research

Efficacy of a dynamic orthosis on the upper limbs in the chronic phase of strokes. A longitudinal study.
CONCLUSIONS: Rehabilitation following a stroke improves strength and body activities in the upper limb. The use of a dynamic orthosis can further improve the strength in this limb, but additional research is needed to confirm our results. PMID: 28849862 [PubMed - in process]
Source: Revista de Neurologia - August 30, 2017 Category: Neurology Authors: Gonzalez-Bernal J, de la Fuente-Anuncibay R, Gonzalez-Santos J, Cuesta-Gomez JL, Cubo E Tags: Rev Neurol Source Type: research

The Temporospatial Role of Microcirculatory Dysfunction in the Prediction of Ischemia or Infarction in Patients with Aneurysmal Subarachnoid Hemorrhages (P2.281)
Conclusions:This ongoing study suggests that patients with low mean minimal pulsatility index had poor functional outcomes relative to patients that had higher mean pulsatility index.Study Supported by: This work was supported in part by a grant from the McKnight Brain Research Foundation, Brain and Spinal Cord Injury Research Trust Fund, a grant from NIH National Institute of Neurological Disorders and Stroke, a Medical Student Anesthesia Research Fellowship awarded by the Foundation for Anesthesiology Education and Research, a grant from the Medical Student Research Program at the University of Florida, and the Departmen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zamora, A., Gupta, A., Leclerc, J., Vasilopoulos, T., Dore, S. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Early Palliative Care Consultation Decreases Length of Stay in Severe Stroke Patients (P1.211)
Conclusions:Early PCC in severe stroke patients decreased hospital LOS by 3 days. This may be due to prompt clarification of goals of care and hastened discharge to hospice. Advanced age, poor pre-stroke functional status, and severe post-stroke deficits and disability warrant early PCC. In addition to decreasing LOS, further study is needed to determine whether early PCC also limits futile tests, procedures, and iatrogenic complications. Ultimately, timely identification of PCC candidates may produce higher satisfaction and decreased hospital costs.Disclosure: Dr. Schloss has nothing to disclose. Dr. Tversky has nothing t...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Schloss, E. R., Tversky, S., Katz, J. M., Wright, P. Tags: Pain and Palliative Care Source Type: research

Early Improvement in NIH Stoke Scale during Inter-hospital Transfer is Common and is Associated with Lower In-hospital Mortality (P3.044)
Conclusions:Early improvement in stroke severity during interhospital transfer is common, and is not confined to patients receiving thrombolysis. These early improvement patients have very low mortality, and it is substantially lower than in those without early improvement, despite higher initial NIHSS. This has important implications for assessing the safety and efficacy of drip and ship thrombolysis or other pre-transfer interventions. Further research is warranted.Disclosure: Dr. Mahmood has nothing to disclose. Dr. Ali has nothing to disclose. Dr. Siddiqui has nothing to disclose. Dr. Cohen has nothing to disclose. Dr....
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mahmood, S., Ali, S., Siddiqui, K., Cohen, A., Schwamm, L. Tags: Practice, Policy, and Ethics III Source Type: research

Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis? Clinical Sciences
Conclusions— In children with dissection and transient cerebral arteriopathy, cerebral arteries demonstrate increased tortuosity. Quantified arterial tortuosity may represent a clinically relevant imaging biomarker of vascular biology in pediatric stroke.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Wei, F., Diedrich, K. T., Fullerton, H. J., deVeber, G., Wintermark, M., Hodge, J., Kirton, A., the Vascular Effects of Infection in Pediatric Stroke (VIPS) Investigators, Dowling, Benedict, Bernard, Fox, Friedman, Lo, Ichord, Tan, Mackay, Hernandez, Hump Tags: Risk Factors, Angiography, Magnetic Resonance Imaging (MRI), Ischemic Stroke, Vascular Disease Clinical Sciences Source Type: research

Safety and Efficacy of IV-tPA Use in Patients 80 Years and Older- A Retrospective Review (P2.305)
Conclusion—We observed no increase in sICH post IV-tPA in patients 80+ when compared to those younger. Higher mortality in those 80+ likely due to baseline disabilities. Within the 80+ group, predictors of mortality and poor outcomes included disabilities prior to hospitalization, prior stroke/TIA, higher NIHSS at admission, sICH post treatment and higher diastolic blood pressure.Disclosure: Dr. Lau has nothing to disclose. Dr. Romero has nothing to disclose. Dr. Kwan has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Babikian has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Lau, H., Romero, J., Kwan, S., Kase, C., Babikian, V. Tags: Acute Therapy: IV t-PA Source Type: research

GPER expressed on microglia mediates the anti‐inflammatory effect of estradiol in ischemic stroke
ConclusionsOur studies have suggested that GPER expressed on microglia mediated the anti‐inflammatory effect of estradiol after ischemic stroke. Our studies could potentially help to develop more specific drugs to manage inflammation postischemic stroke. GPER was highly expressed in activated microglia after ischemia and estradiol. The specific GPER agonist G1 could inhibit the secretion of proinflammatory cytokines including IL‐1β and TNF‐α, which the anti‐inflammatory effect of G1 and E2 were both abolished by the specific GPER antagonist G15.
Source: Brain and Behavior - March 21, 2016 Category: Neurology Authors: Tian‐Zhi Zhao, Qian Ding, Jun Hu, Shi‐Ming He, Fei Shi, Lian‐Ting Ma Tags: Original Research Source Type: research

Neurologic Complications of Extracorporeal Membrane Oxygenation.
CONCLUSIONS: Given the increasing utilization of ECMO and the high costs and poor outcomes associated with neurologic complications, more research is needed to help determine the best way to prevent these sequelae in this patient population. PMID: 26320848 [PubMed - as supplied by publisher]
Source: Journal of Clinical Neurology - September 1, 2015 Category: Neurology Tags: J Clin Neurol Source Type: research

Novel TIA biomarkers identified by mass spectrometry‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean‐Marc Olivot Tags: Research Source Type: research

Novel TIA biomarkers identified by mass spectrometry ‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean ‐Marc Olivot Tags: Research Source Type: research

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