Decompressive Craniectomy for Traumatic Brain Injury: Postoperative TCD Cerebral Hemodynamic Evaluation

Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refractory elevated ICP (1, 2). However, randomized controlled trials failed to disclose the efficacy of this procedure for improving these patients' neurological outcome (3, 4). This means that ICP control to ensure CPP, as the sole treatment strategy, is not sufficient to achieve satisfactory therapeutic results in most cases. New research should focus on different pathophysiological mechanisms of posttraumatic brain swelling. Transcranial Doppler (TCD) ultrasonography is a non-invasive and bedside method for real-time assessment of cerebral blood circulation. This technique is routinely used in clinical and scientific scenario (5–8). To date, few studies have addressed the cerebral hemodynamic and metabolic effects of DC for uncontrolled elevation of ICP (2, 9–15). To our knowledge, there are no studies describing the different cerebral hemo...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

Related Links:

Abstract Rhinoconjunctivitis is a public health problem that causes major illness and disability worldwide. Epidemiological studies intended to determine the burden of rhinoconjunctivitis in Kuwait are limited. Hence, this study sought to estimate the prevalence of rhinoconjunctivitis among adolescents in Kuwait and explore its association with different risk factors. Schoolchildren aged 11-14 years (n = 3,864) were enrolled in a cross-sectional study. Parents completed questionnaires regarding their children's clinical history and symptoms of rhinoconjunctivitis and relevant exposures. Associations ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, sitagliptin nanoparticles (sizes ranging from 210 to 618 nm) were developed. The bioadhesion properties of the nanoparticles, as well as the swelling of the nanoparticles on the mucus membrane aided in sustained drug release. The pattern of drug release was in accordance with the Peppas model. Fourier-transform infrared (FTIR) spectroscopy demonstrated that there were no significant interactions between sitagliptin and chitosan. Differential scanning calorimetry (DSC) results showed an absence of drug peaks due to the fact that the drug was present in an amorphous state. Mucoadhesive nanoparticles wer...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: Condylar tissue changes point to the osteoclastic activity in the posterior region of the condyle. These adaptive changes point to bone resorption in the posterior condyle. Type II collagen and VEGF contribute to the MCC remolding induced by the TIPD. The ultrastructural changes in the posterior condylar area in response to mechanical stresses are recoverable at the initial stage. PMID: 31815128 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract For bone tissue engineering, the porous scaffold should provide a biocompatible environment for cell adhesion, proliferation, and differentiation and match the mechanical properties of native bone tissue. In this work, we fabricated porous polyetherimide (PEI) scaffolds using a three-dimensional (3D) printing system, and the pore size was set as 800 μm. The morphology of 3D PEI scaffolds was characterized by the scanning electron microscope. To investigate the mechanical properties of the 3D PEI scaffold, the compressive mechanical test was performed via an electronic universal testing system. F...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour. Striatum, which is a component of the basal ganglia, is involved in facilitating voluntary movement while the cerebellum is involved in the maintenance of balance and coordination of voluntary movements. Dopamine, serotonin, gamma-aminobutyric acid (GABA), and glutamate, to name a few, interact in regulating the excitation and inhibition of motor neuro...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
With each single X-ray pulse having its own characteristics, understanding the individual property of each X-ray free-electron laser (XFEL) pulse is essential for its applications in probing and manipulating specimens as well as in diagnosing the lasing performance. Intensive research using XFEL radiation over the last several years has introduced techniques to characterize the femtosecond XFEL pulses, but a simple characterization scheme, while not requiring ad hoc assumptions, to address multiple aspects of XFEL radiation via a single data collection process is scant. Here, it is shown that single-particle diffraction pa...
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Tags: X-ray free-electron lasers single-particle diffraction pulse energy coherence beam profile research papers Source Type: research
In this study the first in situ high-pressure single-crystal X-ray diffraction experiments at Xpress, the Indo-Italian beamline of the Elettra synchrotron, Trieste (Italy), are reported. A description of the beamline experimental setup and of the procedures for single-crystal centring, data collection and processing, using diamond anvil cells, are provided. High-pressure experiments on a synthetic crystal of clinoenstatite (MgSiO3), CaCO3 polymorphs and a natural sample of leucophoenicite [Mn7Si3O12(OH)2] validated the suitability of the beamline experimental setup to: (i) locate and characterize pressure-induced phase tra...
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Tags: Elettra synchrotron Xpress beamline single-crystal XRD high pressure beamlines Source Type: research
Abstract Worldwide, millions of individuals suffer an ischemic stroke each year, causing major disability, especially in the elderly, where stroke is the number one cause of disability. However, to date, no effective therapy exists that targets the functional recovery after stroke. After necrosis, neuroinflammation is a common feature of the acute stroke and a major obstacle to tissue restoration. In the lesioned area, the dying neurons release chemotactic signals, such as fractalkine/CX3CL1, which evoke "eat-me" signals that are recognized by microglia expressing complement C3a receptor (C3aR), resultin...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Conclusions: The knowledge about the cause, possible susceptibility, better treatment options, and attitude of the participants were similar to other low-income settings. The negative attitude was high and multidimensional. All stakeholders must work to increase awareness about the cause, symptoms, and treatment options for epilepsy and to decrease the negative attitude of the community. PMID: 31814856 [PubMed - in process]
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Mingfang Zhu, Rui Li, Mushen Lai, Hongqing Ye, Ning Long, Jianshan Ye, Jingyue WangAbstractAn original copper nanoparticle incorporating a cationic surfactant cetyltrimethylammonium bromide (CTAB)-graphene film had been successfully developed for the simultaneous determination of gatifloxacin and perflocacin with electrochemical method. The surface morphology of the nanocomposites was characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The synergistic effect of copper nanopart...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
More News: Academia | Accidents | Anemia | Anesthesia | Anesthesiology | Brain | Brazil Health | Canada Health | Cardiology | Children | Computers | CT Scan | Databases & Libraries | Disability | Epidemiology | Head Injury | Heart | Heart Failure | Hemorrhagic Stroke | Hyperactivity | Hypertension | Ischemic Stroke | Italy Health | Kale | Medical Ethics | Men | Middle East Health | Mitochondria | Mitochondrial Disease | Neurology | Neuroscience | Neurosurgery | Perfusion | PET Scan | Post Traumatic Stress Disorder | Psychiatry | Reproduction Medicine | Sickle Cell Anemia | Statistics | Stroke | Students | Study | Subarachnoid Hemorrhage | UK Health | Universities & Medical Training