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Specialty: Neurology
Condition: Ischemic Stroke
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Total 20790 results found since Jan 2013.
Perceived performance of activities of daily living by stroke patients: key in decision to call EMS and outcomes
ConclusionPerception of unimpaired performance of ADL is a crucial barrier to appropriate help-seeking behavior after acute stroke, leading to undertreatment and less improvement in clinical symptoms. Thus, beyond improving the public’s knowledge of stroke symptoms, future public education campaigns should focus on the need for calling the EMS in case of stroke symptoms even if daily activities do not seem to be severely impaired.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Diffusion tensor free water MRI predicts progression of FLAIR white matter hyperintensities after ischemic stroke
DiscussionBaseline increased interstitial fluid, estimated as FW on DTI, predicted the progression of NAWM to WMH over the following year. These results implicate the presence of FW in the pathogenesis of cerebral small vessel disease progression.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
CNS-LAND score: predicting early neurological deterioration after intravenous thrombolysis based on systemic responses and injury
ConclusionCNS-LAND score is a reliable predictor of END risk in AIS patients receiving IVT.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research
Brain MRI correlations with disease burden and biomarkers in Fabry disease
ConclusionBrain MRI revealed progressive lacunar infarctions, white matter hyperintensities, and decreased brain volume in patients with Fabry disease. Brain MRI lesions were closely related to onset-age; disease duration, severity, burden; and plasma Lyso-Gb3. However, they were not associated with sex, α-galactosidase A activity, orGLA mutation type.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research
A typology of cerebral small vessel disease based on imaging markers
ConclusionThe study confirmed the existence of different SVD types with different relationships to stroke outcome. EPVS and WMH were identified as imaging features of presumably early progression. The number of microbleeds and WMH severity appear to be promising biomarkers for distinguishing clinical subgroups. Further understanding of SVD progression might require consideration of refined SVD features, e.g., for EPVS and type of lacunes.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
Low value of inherited thrombophilia testing among patients with stroke or transient ischemic attack: A three-year retrospective study
Inherited thrombophilia testing in the acute inpatient setting is controversial and expensive, and rarely changes clinical management. We evaluated ordering patterns and results of inpatient inherited thrombophilia testing for patients who presented with an isolated acute ischemic stroke or transient ischemic attack (TIA) without concurrent venous thromboembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Shyam Majmundar, Sameep Thapa, Elan S. Miller, Rodney Bell, Robin Dharia, Diana Tzeng, Shaista Alam, Ruben Rhoades Source Type: research
Before juvenile stroke can be attributed to MYH11 variants, alternative etiologies and pathophysiologies must be adequately ruled out
We read with interest the article by Raghuram et al. on a 12 year-old female who developed severe ischemic stroke (NIHSS 16) due to right proximal middle cerebral artery (MCA) occlusion [1]. Despite thrombolysis and thrombectomy, the patient's recovery was incomplete [1]. The cause of the occlusion was attributed to a focal dissection of the MCA due to the variant IVS32G>A in MYH11, which was also found in the maternal grandmother, mother, older sister, and a maternal cousin, two of whom had aortic dissection in the past [1].
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
A nomogram predicts early neurological deterioration after mechanical thrombectomy in patients with ischemic stroke
DiscussionOur study established and validated a nomogram to stratify the risk of END before mechanical embolectomy and identify high-risk patients, who should be more cautious when making clinical decisions.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
Case report: Retrograde endovascular recanalization of vertebral artery occlusion with non-tapered stump via the deep cervical collateral
ConclusionAntegrade endovascular recanalization of VA occlusion with a non-tapered stump is a challenge. The retrograde endovascular method via the cervical collateral may be an alternative for this type of VA occlusion, which requires further exploration.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
The effects of low-intensity resistance training with blood flow restriction versus traditional resistance exercise on lower extremity muscle strength and motor functionin ischemic stroke survivors: a randomized controlled trial
CONCLUSION: LIRT-BFR produced a significant improvement in muscle strength, balance, walking capacity, and anxiety and depression in ischemic stroke patients, and the improvement are comparable to HIRT.CLINICAL TRIAL REGISTRATION: NCT05281679.PMID:37724785 | DOI:10.1080/10749357.2023.2259170
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Ishtiaq Ahmed Rustem Mustafoglu Belgin Erhan Source Type: research
Intracranial arterial stenosis and recurrence in stroke patients with different risk stratifications by Essen stroke risk score
CONCLUSION: ICAS was an independent predictor of both 3- and 12-month stroke recurrence in low-risk but not high-risk patients with minor ischemic stroke or transient ischemic attack according to ESRS stratification.PMID:37724803 | DOI:10.1080/01616412.2023.2257415
Source: Neurological Research - September 19, 2023 Category: Neurology Authors: Yue Suo Jing Jing Xia Meng Zixiao Li Yuesong Pan Hongyi Yan Yong Jiang Liping Liu Xingquan Zhao Yilong Wang Hao Li Yongjun Wang CHANCE investigators Source Type: research
Pure Sensory Lacunar Infarction in the Thalamus Presented as Bilateral Hypogeusia: A Case Report
CONCLUSION: The exact gustatory pathway in humans remains uncertain nowadays. First, there were few reports about dysgeusia, which might be related to clinical neglect of taste deficits. Second, our knowledge of the human gustatory pathway depends solely on sporadic cases of taste-involved brain lesions. We reported a case of bilateral hypogeusia after right thalamic infarction. This finding indicates that, although there might be laterality of gustatory fibers to the left hemisphere, anatomical variations may exist in the human gustatory system. More research is needed to elucidate the understanding of the gustatory pathw...
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Yu-Chun Wang I-Hsu Chen Poyin Huang Source Type: research
First-Ever Ischemic Stroke In Covid-19: How Is It Different? - A Stroke Registry-Based Study From South India
Acta Neurol Taiwan. 2023 Dec 30;32(4):190-201.ABSTRACTStroke associated with COVID-19 has been characterised in several multicentre retrospective studies and meta-analyses. However, they did not distinguish first-ever ischemic strokes (F-AIS). Therefore, we aimed to study the incidence, clinical characteristics, and outcomes of a cohort of F-AIS associated with COVID-19 during the first wave of the pandemic and compare this cohort with those of F-AIS without COVID-19, COVID-19 without stroke. We also sought to compare the stroke admissions and mechanisms during the pandemic and immediate prepandemic periods.PMID:37723911
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Muralidhar Reddy Y Jagarlapudi Mk Murthy Sreekanth Reddy Y Abhinay Kumar Gattu Shyam K Jaiswal Lalitha Pidaparthi Subhendu Parida Santhosh Kumar B Syed Osman Shanti Naidu Kamatam Source Type: research
