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Specialty: Neurology
Condition: Ischemic Stroke

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Total 20790 results found since Jan 2013.

The effects of low-intensity resistance training with blood flow restriction versus traditional resistance exercise on lower extremity muscle strength and motor functionin ischemic stroke survivors: a randomized controlled trial
CONCLUSION: LIRT-BFR produced a significant improvement in muscle strength, balance, walking capacity, and anxiety and depression in ischemic stroke patients, and the improvement are comparable to HIRT.CLINICAL TRIAL REGISTRATION: NCT05281679.PMID:37724785 | DOI:10.1080/10749357.2023.2259170
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Ishtiaq Ahmed Rustem Mustafoglu Belgin Erhan Source Type: research

First-Ever Ischemic Stroke In Covid-19: How Is It Different? - A Stroke Registry-Based Study From South India
Acta Neurol Taiwan. 2023 Dec 30;32(4):190-201.ABSTRACTStroke associated with COVID-19 has been characterised in several multicentre retrospective studies and meta-analyses. However, they did not distinguish first-ever ischemic strokes (F-AIS). Therefore, we aimed to study the incidence, clinical characteristics, and outcomes of a cohort of F-AIS associated with COVID-19 during the first wave of the pandemic and compare this cohort with those of F-AIS without COVID-19, COVID-19 without stroke. We also sought to compare the stroke admissions and mechanisms during the pandemic and immediate prepandemic periods.PMID:37723911
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Muralidhar Reddy Y Jagarlapudi Mk Murthy Sreekanth Reddy Y Abhinay Kumar Gattu Shyam K Jaiswal Lalitha Pidaparthi Subhendu Parida Santhosh Kumar B Syed Osman Shanti Naidu Kamatam Source Type: research

Pure Sensory Lacunar Infarction in the Thalamus Presented as Bilateral Hypogeusia: A Case Report
CONCLUSION: The exact gustatory pathway in humans remains uncertain nowadays. First, there were few reports about dysgeusia, which might be related to clinical neglect of taste deficits. Second, our knowledge of the human gustatory pathway depends solely on sporadic cases of taste-involved brain lesions. We reported a case of bilateral hypogeusia after right thalamic infarction. This finding indicates that, although there might be laterality of gustatory fibers to the left hemisphere, anatomical variations may exist in the human gustatory system. More research is needed to elucidate the understanding of the gustatory pathw...
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Yu-Chun Wang I-Hsu Chen Poyin Huang Source Type: research

First-Ever Ischemic Stroke In Covid-19: How Is It Different? - A Stroke Registry-Based Study From South India
Acta Neurol Taiwan. 2023 Dec 30;32(4):190-201.ABSTRACTStroke associated with COVID-19 has been characterised in several multicentre retrospective studies and meta-analyses. However, they did not distinguish first-ever ischemic strokes (F-AIS). Therefore, we aimed to study the incidence, clinical characteristics, and outcomes of a cohort of F-AIS associated with COVID-19 during the first wave of the pandemic and compare this cohort with those of F-AIS without COVID-19, COVID-19 without stroke. We also sought to compare the stroke admissions and mechanisms during the pandemic and immediate prepandemic periods.PMID:37723911
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Muralidhar Reddy Y Jagarlapudi Mk Murthy Sreekanth Reddy Y Abhinay Kumar Gattu Shyam K Jaiswal Lalitha Pidaparthi Subhendu Parida Santhosh Kumar B Syed Osman Shanti Naidu Kamatam Source Type: research

Cost of treatment failure: Medicare spending on stroke for atrial fibrillation patients not receiving anticoagulation
It is well known that atrial fibrillation (AF) patients not receiving anticoagulants are at higher risk of Ischemic Stroke (IS).
Source: Journal of the Neurological Sciences - September 19, 2023 Category: Neurology Authors: Steven D. Culler, W. Frank Peacock, April W. Simon Source Type: research

Blood biomarker changes following therapeutic hypothermia in ischemic stroke
ConclusionAlthough the exact roles of MMP3, FABP, and IL-8 in hypothermia-treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.
Source: Brain and Behavior - September 18, 2023 Category: Neurology Authors: Elena Pal à, Anna Penalba, Alejandro Bustamante, Teresa García‐Berrocoso, Marcel Lamana‐Vallverdú, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R Macleod, Bernd Kallmünzer, Stefan Schwab, Joan Montaner Tags: BRIEF REPORT Source Type: research

TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction
Exp Neurol. 2023 Sep 15:114542. doi: 10.1016/j.expneurol.2023.114542. Online ahead of print.ABSTRACTAutophagy is considered a double-edged sword, with a role in the regulation of the pathophysiological processes of the central nervous system (CNS) after cerebral ischemia-reperfusion injury (CIRI). The 18-kDa translocator protein (TSPO) is a highly conserved protein, with its expression level in the nervous system closely associated with the regulation of pathophysiological processes. In addition, the ligand of TSPO reduces neuroinflammation in brain diseases, but the potential role of TSPO in CIRI is largely undiscovered. ...
Source: Experimental Neurology - September 17, 2023 Category: Neurology Authors: Yusufu Mahemuti Kaheerman Kadeer Riqing Su Abudureheman Abula Yirizhati Aili Aierpati Maimaiti Subinuer Abulaiti Maimaitiyasheng Maimaitituerxun Tong Miao Shihao Jiang Aximujiang Axier Maimaitili Aisha Yongxin Wang Xiaojiang Cheng Source Type: research

CircNCOA4 knockdown attenuates OGD-induced neuron injury through miR-338-5p/PDE4B axis
Exp Brain Res. 2023 Sep 16. doi: 10.1007/s00221-023-06702-w. Online ahead of print.ABSTRACTCircular RNAs (circRNAs) have been revealed to be involved in the pathology of acute ischemic stroke (AIS). Herein, we aimed to study the role and mechanism of circNCOA4 in ischemic stroke. The neuron-like cell line SK-N-SH of the experiment group was cultured in oxygen-glucose deprivation (OGD) condition. Cell viability and apoptosis were evaluated by cell counting kit-8 and flow cytometry. The oxidative damage and endoplasmic reticulum stress (ERS) were analyzed by measuring the production of reactive oxygen species (ROS), malondia...
Source: Brain Research - September 16, 2023 Category: Neurology Authors: Danyang Wang Sai Xiao Xiaoming Li Wenbo Qi Source Type: research

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway
CONCLUSION: Rhein attenuates cerebral I/R injury by inhibiting ferroptosis via the NRF2/SLC7A11/GPX4 axis, highlighting its potential as a therapeutic agent for ischemic stroke.PMID:37714424 | DOI:10.1016/j.expneurol.2023.114541
Source: Experimental Neurology - September 15, 2023 Category: Neurology Authors: Hua Liu Tian-Ai Zhang Wen-Yue Zhang Si-Rui Huang Yue Hu Jia Sun Source Type: research

Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. Howev...
Source: Journal of Neuroinflammation - September 15, 2023 Category: Neurology Authors: Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner and Dirk M. Hermann Tags: Research Source Type: research

The murky waters of sex differences in post-stroke cognitive impairment
Nature Reviews Neurology, Published online: 15 September 2023; doi:10.1038/s41582-023-00880-5A new study indicates that although men and women are equally likely to experience cognitive impairment after acute ischaemic stroke, there are sex differences in particular cognitive domains. Whether these differences are directly linked to biological sex is uncertain, as many factors, including age and pre-stroke factors, could contribute to cognitive outcomes.
Source: Nature Reviews Neurology - September 15, 2023 Category: Neurology Authors: Louise D. McCullough Source Type: research

CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
AbstractActivated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated the function of circPTP4A2 in regulating microglia polarization in IS. IS models were established by MACO/R and OGD/R treatment. TTC staining was employed to detect cerebral infarct size. Cell vitality was measured using CCK-8 assay. CD16 and CD206 levels were examined using flow cytometry. The interactions between circPTP4A2, miR-20b-5p, and YTHDF1 were analyzed by dual-luciferase reporter gene, RIP, or RNA pull-down assays. circPTP4A2 was upregulated in IS patients. circPTP4A2 knockdown allevi...
Source: NeuroMolecular Medicine - September 14, 2023 Category: Neurology Source Type: research