Before juvenile stroke can be attributed to MYH11 variants, alternative etiologies and pathophysiologies must be adequately ruled out

We read with interest the article by Raghuram et  al. on a 12 year-old female who developed severe ischemic stroke (NIHSS 16) due to right proximal middle cerebral artery (MCA) occlusion [1]. Despite thrombolysis and thrombectomy, the patient's recovery was incomplete [1]. The cause of the occlusion was attributed to a focal dissection of the MCA due to the variant IVS32G>A in MYH11, which was also found in the maternal grandmother, mother, older sister, and a maternal cousin, two of whom had aortic dissection in the past [1].
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research