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Total 386 results found since Jan 2013.

Nonbacterial Thrombotic Endocarditis Related to Adenocarcinoma of the Uterine Cervix
We report a 66-year-old female patient who presented with acute onset of visual loss with relative afferent pupillary defect, hemineglect, hemihypesthesia, and apraxia. Magnetic resonance imaging of the brain demonstrated different stages of ischemic stroke in different vascular territories, suggesting cardiogenic embolism. Past history was significant for advanced-stage adenocarcinoma of the uterine cervix under chemoradiation treatment. On echocardiogram, vegetation at the aortic valve was observed. With the absence of evidence of infectious endocarditis, diagnosis of nonbacterial thrombotic endocarditis was made, and th...
Source: Case Reports in Neurology - December 14, 2020 Category: Neurology Source Type: research

Neurologic Complications in Patients With Cancer
PURPOSE OF REVIEW Neurologic complications in patients with cancer can significantly impact morbidity and mortality. Although these complications can be seen in patients without cancer as well, the purpose of this review is to highlight how the presentation, etiology, and management of delirium, seizures, cerebrovascular disease, and central nervous system infections may be different in patients with cancer. RECENT FINDINGS Some of the newer anticancer therapies are associated with neurologic complications. Delirium and seizures have been described in patients receiving chimeric antigen receptor (CAR) T-cell the...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Association of admission leukocyte count with clinical outcomes in acute ischemic stroke patients undergoing intravenous thrombolysis with recombinant tissue plasminogen activator.
CONCLUSION: Lower admission leukocyte count independently predicts good and excellent outcomes at 3 months in AIS patients undergoing rt-PA treatment. PMID: 33243121 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - November 25, 2020 Category: Neurology Authors: Chen J, Zhang FL, Lv S, Jin H, Luo Y, Qu Y, Guo ZN, Yang Y Tags: Curr Neurovasc Res Source Type: research

Endovascular Therapy of Acute Ischemic Stroke in Patients with Large-Vessel Occlusion Associated with Active Malignancy
Approximately 15% of cancer patients have concomitant cerebrovascular disease.1,2 The frequency of ischemic and hemorrhagic stroke in this group of patients is similar to the general population2, and about one in ten stroke patients may have a concurrent malignancy.3 Intravenous thrombolysis (IVT) in these patients is often contraindicated and is used less frequently due to various possible comorbidities.4 While EVT is a well-established approach to treat acute ischemic stroke (AIS) secondary to large vessel occlusion (LVO) 5,6,7,8, there is paucity of data with regards to EVT success and outcomes in patients with active malignancy.
Source: Journal of Stroke and Cerebrovascular Diseases - November 24, 2020 Category: Neurology Authors: Tomohiko Ozaki, Patrick Nicholson, Joanna D. Schaafsma, Ronit Agid, Timo Krings, Aleksandra Pikula, Vitor Mendes Pereira Source Type: research

Stroke Treatment in the Setting of Systemic Disease
AbstractWhile the possible stroke risks for more prevalent conditions, such as cardiac disease or cancer, are important to recognize, there are other equally devastating systemic diseases that can affect younger adults and, if not cautious, may be misdiagnosed if stroke is the initial presentation.Purpose of reviewWe aim to discuss treatments of three rarer, but important systemic diseases associated with an increased incidence of ischemic stroke, specifically sickle cell anemia, human immunodeficiency virus (HIV), and Takayasu ’s arteritis.Recent findingsGiven that individuals with these diseases are now living longer, ...
Source: Current Treatment Options in Neurology - November 13, 2020 Category: Neurology Source Type: research

Diet and Lifestyle as Risk Factors for Carotid Artery Disease: A Prospective Cohort Study
Conclusions: In conclusion, the present study found a trend toward a protective effect of higher intake of vegetables and fruit against incident CAD. More prospective studies investigating the association between diet and CAD and stroke are needed in order to give firm recommendations.Cerebrovasc Dis
Source: Cerebrovascular Diseases - October 19, 2020 Category: Neurology Source Type: research

The Risk Factors for Death within 6 Months After Ischemic Stroke in Patients with Cancer
While the intravenous recombinant tissue plasminogen activator (rt-PA) therapy for acute ischemic stroke patients with cancer is recommended when survival of ≥ 6 months is expected, the risk factors for death and stroke recurrence within 6 months after stroke are not well known. Thus, we aimed to identify markers for death and recurrence risks within six months from stroke onset in patients with cancer.
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2020 Category: Neurology Authors: Yoko Tsuchihashi, Takahiro Shimizu, Hisanao Akiyama, Yuta Hagiwara, Kaima Soga, Naoki Takao, Kenji Uchino, Toshiyuki Yanagisawa, Junji Yamauchi, Tomoo Sato, Yasuhiro Hasegawa, Yoshihisa Yamano Source Type: research

D-dimer and Body CT to Identify Occult Malignancy in Acute Ischemic Stroke
Patients with acute ischemic stroke associated with cancer have D-dimer elevations greater than those with acute ischemic stroke or cancer alone. While D-dimer has been proposed as a screening tool to identify such patients, its use in clinical practice to identify malignancy and to inform the use of CT scanning has not been well characterized.
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2020 Category: Neurology Authors: Jon Rosenberg, David Do, Brett Cucchiara, Steven R. Mess é Source Type: research

Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF- κB-driven IL-1β Transcription
AbstractNeuroinflammation has been shown to exacerbate ischemic brain injury, and is considered as a prime target for the development of stroke therapies.Clinacanthus nutans Lindau (C. nutans) is widely used in traditional medicine for treating insect bites, viral infection and cancer, due largely to its anti-oxidative and anti-inflammatory properties. Recently, we reported that an ethanol extract from the leaf ofC. nutans could protect the brain against ischemia-triggered neuronal death and infarction. In order to further understand the molecular mechanism(s) for its beneficial effects, two experimental paradigms, namely,...
Source: NeuroMolecular Medicine - October 5, 2020 Category: Neurology Source Type: research

Pathophysiology, Mechanism, and Outcome of Ischemic Stroke in Cancer Patients
The purpose of this study is to assess the risk factors, biomarkers of stroke, mechanism, and outcomes of cerebral infarction among cancerous diseases.
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2020 Category: Neurology Authors: Mohamed Abdelsalam, Mohammad Abu-Hegazy, Hend Ahmed El-Hadaad, Hanan Wahba, Hossam Egila, Ahmed Esmael Source Type: research

Clinical Features of Trousseau Syndrome With Cerebral Infarction as the Initial Manifestation
Conclusions: Trousseau syndrome with cerebral infarction as the initial manifestation was associated with metastatic cancer and depressive state. There was no difference in coagulation status between the 2 groups.
Source: The Neurologist - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Occult lung cancer manifesting within the first year after stroke
Lung cancer and stroke share smoking as a major cause of disease. We investigated prevalence and risk of occult lung cancer with manifestation during the first year after stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Alejandro Daniel Babore, Anne Julie Tybjerg, Klaus Kaae Andersen, Tom Skyhoj Olsen Source Type: research

Clinical Characteristics and Analysis of Lung Cancer- Associated Acute Ischemic Stroke
The incidence of lung cancer and acute ischemic stroke remains high in recent years, both of which occur mostly in people over 60 years old. In the present study, we aimed to further clarify the pathogenesis of lung cancer-associated acute ischemic stroke (LCA-AIS) by comparing and analyzing clinical characteristics of stroke patients with or without lung cancer.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Jing Zhang, Jingxia Zhao Source Type: research

Three territory sign in cancer-related acute ischemic stroke
ABSTRACT In this manuscript we pay a tribute to Pierre Marie (1853-1940), highlighting his great contribution to medicine and neurology describing several diseases and syndromes. We mainly emphasize aspects of his personal life and personality traits. Considered one of the three greatest neurologists of the late nineteenth and early twentieth centuries, his brilliant career began at La Salp êtrière, followed by the development of a neurological school at Hospice Bicêtre. Pierre Marie had numerous disciples around the world, including Brazil, and published on various neurological and endocrinological themes. Back to La S...
Source: Arquivos de Neuro-Psiquiatria - July 31, 2020 Category: Neurology Source Type: research

Hematological Abnormalities and Malnutrition Mediate Pathway between Cancer and Outcomes in Ischemic Stroke Patients
The present study aimed to examine whether variables including D-dimer, high-sensitivity C-reactive protein (hsCRP), hemoglobin, platelet count, and nutritional status mediate the pathway between cancer and ischemic stroke outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Yasufumi Gon, Daijiro Kabata, Tomohiro Kawano, Hideaki Kanki, Kenichi Todo, Tsutomu Sasaki, Ayumi Shintani, Hideki Mochizuki Source Type: research