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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

Safety of vasodilator stress myocardial perfusion imaging in patients with elevated cardiac biomarkers
Conclusion In the setting of elevated troponin, serious complications associated with either exercise or vasodilator stress testing appear to be relatively rare with no increased risk attributable to a particular vasodilator agent.
Source: Journal of Nuclear Cardiology - February 22, 2016 Category: Nuclear Medicine Source Type: research

New Insights: PET Imaging to Document Synergistic Therapy Effect of the "Old," Ancient Recipe and the "New," Modern Drug in Stroke
Source: Journal of Nuclear Medicine - March 31, 2016 Category: Nuclear Medicine Authors: Civelek, A. C. Tags: Invited Perspectives Source Type: research

Evaluation of ECG-gated 11 Cacetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency
Conclusions Although analysis-related improvements in accuracy are recommended, LV geometry estimated from ECG-gated [11C]acetate PET correlate excellently with CMR and can indeed be used to evaluate MEE.
Source: Journal of Nuclear Cardiology - April 18, 2016 Category: Nuclear Medicine Source Type: research

18FFDPN for PET Imaging of Soluble Epoxide Hydrolase (sEH)
Conclusions [18F]FDPN, a potent sEH inhibitor, readily enters the mouse and baboon brain and radiolabels sEH with high specificity (up to 95%) in both species. This first-in-class agent may enable study of sEH non-invasively in a variety of neurological diseases.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Horti, A., Wang, Y., Minn, I., Koehler, R., Dannals, R., Pomper, M. Tags: Neurosciences - Basic Science 1 Source Type: research

Assessment of muscle function using hybrid pet/mri: comparison of quantifying muscle activation using 18f-fdg pet and t2 mri in human subjects
Conclusions There exists a strong linear correlation between T2 changes and glucose uptake which did not vary between subjects nor between muscle groups. This is the first assessment of skeletal muscle function using hybrid PET/MRI and the first study to demonstrate the correlation between [18F]-FDG uptake and changes in muscle T2 with physical exercise. Accordingly, it seems that changes in muscle T2 may be used as a surrogate marker for glucose uptake. Such metabolic information of muscle activation could lead to an improved insight and to improved treatment strategies in neuromuscular pathologies such as stroke, spinal ...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Haddock, B. Tags: Musculoskeletal 1 Source Type: research

Brain findings on FDG PET-MRI body sequences that include the head
Conclusions FDG PET-MRI imaging is a rapidly evolving modality that is most commonly employed for cancer evaluation. The standardized base of skull to mid thigh imaging may miss many important pathologies that are discovered even with MRI body sequences. We propose that PET-MRI body sequences that include the head may show added value in the management of patients.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Franceschi, A., Matthews, R., Bangiyev, L., Relan, N., Chaudhry, A., Franceschi, D. Tags: Outcomes/Comparative Effectiveness Research & amp; Radiation Safety Source Type: research

Early detection of doxorubicin-induced cardiotoxicity using the matrix metalloproteinase (MMP) targeted radiotracer, 99mTc-RP805.
Conclusions Increases in myocardial MMP activity precede clinically used echocardiographic indices for early detection of cardiotoxicity, including ejection fraction and global myocardial strain. Therefore, 99mTc-RP805 may serve as a promising approach for early detection of DOX-induced cardiotoxicity when combined with SPECT/CT imaging.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Boutagy, N., Mikush, N., Wang, X., Hawley, C., Liu, C., Sinusas, A. Tags: MTA II: Cardiovascular Basic Science Posters Source Type: research

Periodontitis and carotid arterial inflammation
Conclusions Independent of systemic inflammation, these data suggest that periodontitis and its degree of inflammation appear to be closely associated with vascular inflammation, a crucial mechanism of the development, progression and vulnerability of atherosclerotic plaque.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Cho, J., Choe, J. G., Rhee, S., Choi, S., Eo, J. S., Kim, S. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research

Correlation between F-18 FDG FP-CIT and clinical findings in patients with Parkinsons disease
Conclusions Though striatal volume computed from F-18 FP-CIT PET using occipital lobe as a reference area decreased as the duration of Parkinson’s disease increased, the degree of correlation was weak. There was no statistically significant correlation between the PET parameters and UPDRS. Further studies are needed to determine how to best utilize quantitative F-18 FP-CIT PET in Parkinson’s disease.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Kim, H., O, J. H., Park, H., Han, E. J., Park, Y. H. Tags: MTA II: Neurology Posters Source Type: research

FLT PET/CT in a Case of Demyelinating Disease
Abstract: A 32-year-old woman, with spare previous medical history, presented with neurological symptoms of numbness and diplopia. The patient underwent brain MRI, which revealed a lesion of abnormal signal in the midbrain that could be attributed to subacute stroke; however, consecutive MRIs revealed multiple lesions of abnormal signal pointing to demyelinating disease. During symptoms investigation and MRI findings assessment, the patient underwent a FLT PET/CT examination, which revealed lesions of increased FLT uptake, probably indicating active disease and blood-brain barrier disruption.
Source: Clinical Nuclear Medicine - June 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Ventricular–arterial coupling assessment using gated single-photon emission computed tomography: relationship with reserve pulse pressure and repolarization abnormalities
Conclusion: Noninvasive assessment of VAc is feasible with gated single-photon emission computed tomography and appears to be related to ST-segment depression and reserve rPP.
Source: Nuclear Medicine Communications - October 26, 2016 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Erythropoietin Pretreatment of Transplanted Endothelial Colony-Forming Cells Enhances Recovery in a Cerebral Ischemia Model by Increasing Their Homing Ability: A SPECT/CT Study
Conclusion: Priming with erythropoietin before cell transplantation is an efficient strategy to amplify the migratory and engraftment capacities of ECFCs and their beneficial impact on BBB disruption, apoptosis, and CBF.
Source: Journal of Nuclear Medicine - October 31, 2016 Category: Nuclear Medicine Authors: Garrigue, P., Hache, G., Bennis, Y., Brige, P., Stalin, J., Pellegrini, L., Velly, L., Orlandi, F., Castaldi, E., Dignat-George, F., Sabatier, F., Guillet, B. Tags: Basic Science Investigations Source Type: research

Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal
ConclusionsDip-MBF confirms its role as potent predictor of outcome in HCM. However, the threshold for prediction in a contemporary cohort is higher than that reported in earlier studies. Dip-MBF impairment in the lateral wall, possibly reflecting diffuse disease extending to non-hypertrophic regions, is a sensitive predictor of mortality in HCM.
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 3, 2016 Category: Nuclear Medicine Source Type: research

Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases
AbstractNeuroinflammation is heavily associated with various neurological diseases including Alzheimer ’s disease, Parkinson’s disease, multiple sclerosis, and stroke. It is strongly characterized by the activation of microglia which can be visualized using position emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) has been the preferred target for imaging the inflamma tory progression of the microglial component. TSPO is expressed in the outer mitochondrial membrane and present in very low concentrations in the healthy human brain, but is markedly upregulated in response to brain injury and...
Source: Nuclear Medicine and Molecular Imaging - March 15, 2017 Category: Nuclear Medicine Source Type: research

PET/CT Imaging of Unstable Carotid Plaque with 68Ga-Labeled Somatostatin Receptor Ligand
Conclusion: 68Ga-DOTATATE activity on PET in recently symptomatic carotid plaques is not significantly different from contralateral carotids/plaques. Any activity seen on PET is not shown to be from specific sst2 receptor–mediated uptake in vitro. It is therefore unlikely that sst2 PET/CT imaging will have a role in the detection and characterization of symptomatic carotid plaques.
Source: Journal of Nuclear Medicine - May 1, 2017 Category: Nuclear Medicine Authors: Wan, M. Y. S., Endozo, R., Michopoulou, S., Shortman, R., Rodriguez-Justo, M., Menezes, L., Yusuf, S., Richards, T., Wild, D., Waser, B., Reubi, J. C., Groves, A. Tags: Clinical Source Type: research