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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

A bradykinin derivative differentiates vulnerable and stable plaques in rhesus monkeys with positron emission tomography
Conclusion: P05022 selectively binds to B1R in vivo and generates high contrast images of vulnerable atherosclerotic plaque in monkey model. Our results suggest that P05022 is a promising PET tracer that can differentiate vulnerable atherosclerotic plaques from stable ones with significant specificity.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Xu, Y., Zhang, Z., Benard, F., Lin, K.-S., Liu, Z. Tags: Hermann Blumgart Lecture & amp; Award Session Source Type: research

Blood-brain barrier permeability in association with levodopa-induced dyskinesia in Parkinson's disease: a rubidium-82 PET study
Conclusion: The findings do not support the presence of significant alterations in BBB permeability in PD patients with or without LID. Research Support: This work was supported by the National Institute of Neurological Disorders and Stroke Morris K. Udall Center of Excellence for Parkinson’s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to the last author).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Fujita, K., Dhawan, V., Peng, S., Ma, Y., Eidelberg, D. Tags: New Approaches to Image Parkinson Syndrome Source Type: research

The value of F-18 FDG PET-CT scan in the diagnosis of infection of unknown origin in a patient with aortic valve replacement. in the diagnosis of infection of unknown origin in a patient with Aortic valve replacement. value of F-18 FDG PET/CT scan in the diagnosis of infection of unknown origin in a patient with Aortic valve replacement.
Conclusion: This case illustrates the value of F-18 FDG PET/CT in the diagnosis of and localization of a periaortic valve abscess in a patient with multiple valve replacements, recurrent fevers/sepsis and inconclusive imaging with transthoracic echocardiogram, transesophageal echocardiogram and Indium-111 WBC scan. The localization of the FDG activity to the posterior aspect of the valve which corresponded to the findings on transthoracic echocardiogram was key. Research Support:
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Muhleman, M., Kaur, H., Patel, M., Rydberg, J. Tags: Educational Exhibits Posters Source Type: research

Predicting cardiovascular events associated with normal and abnormal myocardial perfusion imaging and normal coronary angiogram
Conclusion: Abnormal MPI predicts a higher prevalence of future cardiovascular events than by CA alone. Since the MPI measures the physiology of coronary flow including the microvasculature and the coronary flow reserve, these parameters may be more accurate in predicting the likelihood of future events than coronary stenosis alone. Research support: Veterans Health Administration
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Allen, S., Singla, A., Romana, B., Chockalingam, A., Zuidema, M., Dresser, T. Tags: Cardiovascular Clinical Science Posters Source Type: research

18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi
Conclusions: 18F-GP1 binds specifically with high affinity to the GPIIb/IIIa receptor involved in platelet aggregation. Because of its favorable preclinical characteristics, 18F-GP1 is currently being investigated in a human clinical study.
Source: Journal of Nuclear Medicine - July 3, 2017 Category: Nuclear Medicine Authors: Lohrke, J., Siebeneicher, H., Berger, M., Reinhardt, M., Berndt, M., Mueller, A., Zerna, M., Koglin, N., Oden, F., Bauser, M., Friebe, M., Dinkelborg, L. M., Huetter, J., Stephens, A. W. Tags: Basic Source Type: research

Semi-quantitative assessment of pulmonary arterial hypertension associated with congenital heart disease through myocardial perfusion imaging.
CONCLUSION: Semi-quantitative MPI has high diagnostic value in evaluating the severity level of pulmonary arterial hypertension in patients with congenital heart disease. The diagnostic performance of MPI at pre-treatment patients was superior to that at post-treatment. More cases need to be included for further study. PMID: 29177254 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Metabolic Changes in Central Poststroke Pain Following Thalamic Intracerebral Hemorrhage: An 18F-FDG PET Study
Purpose Central poststroke pain (CPSP) is one of the most refractory neuropathic pains following stroke. Injury in the spinothalamic pathway appears crucial for the development of CPSP, but changes in activity in multiple brain regions may also be related. We investigated brain metabolic changes in patients with CPSP following thalamic intracerebral hemorrhage (ICH). Methods Forty-three patients with thalamic ICH were examined. Overall brain metabolism was measured with 18F-FDG PET. Images were analyzed with statistical parametric mapping (SPM12). Patients with CPSP (n = 20) were compared with patients without CPSP (n...
Source: Clinical Nuclear Medicine - February 10, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Imaging Thrombosis with 99mTc-labeled RAM.1-Antibody in vivo
Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).
Source: Nuclear Medicine and Biology - March 16, 2018 Category: Nuclear Medicine Authors: Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, Fran çois Lanza, Patrice Marchand, Christian Gachet, Pierre H. Mangin, David Brasse, Patrice Laquerriere Source Type: research

Correlation of noninvasive imaging of vulnerable carotid artery plaque using NaF and FDG PET/CT and black-blood MRI with cerebral ischemia on brain MRI
Conclusion] These preliminary results suggest that NaF uptake in carotid artery seems to correlate with cerebral ischemic changes.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Norikane, T., Yamamoto, Y., Maeda, Y., Okada, M., Nishiyama, Y. Tags: Cardiovascular Council YIA Symposium Source Type: research

Imaging of Blood-Brain Barrier Disruption by Tc-99m-Tilmanocept Molecular Imaging of a Rodent Model of Traumatic Brain Injury
Conclusions: These results are consistent with the hypothesis that microglial cells bearing CD206 trap fluorescent-labeled Tc-99m-tilmanocept in regions of BBB disruption. This provides the motivation for a clinical trial of intra-venously administered Tc-99m-tilmanocept with the goal of developing a SPECT/CT protocol for the detection of neuro-inflammation.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Vera, D., Barback, C., Wang, S., Head, B., Hoh, C. Tags: Basic Science II Source Type: research

Atherosclerotic Plaque Inflammation Synchronize With Inflammatory Activity of Visceral Fat
Conclusions: We demonstrated that atherosclerotic plaque inflammation was associated with increased inflammation within visceral fat. Our results need to be confirmed by comparison with histologic or other imaging findings. Further evaluation to determine whether metabolic activity of visceral adipose tissue is a marker or mediator of vascular inflammation is also needed.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Kim, S., Choi, S., Seo, H. S., Kwon, H. W., Cho, H. Y., Kwon, H. R. Tags: Advances In Imaging of Atherosclerosis Source Type: research

Detection of Apoptosis with 99mTc rh Annexin-V 128 Imaging in Asymptomatic Patients with Carotid Atherosclerotic Plaque
Conclusions: 99mTc-rhAnnexin V-128 imaging is safe with no observed adverse events or lab result changes. 99mTc-rhAnnexin V-128 imaging of apoptosis is feasible with excellent image quality at one and 2 hours following tracer injection. Significant focal uptake was identified in 1/12 patients and none of the 5 controls. Quantitative analysis of the planar images showed significantly greater uptake of annexin in patients compared to controls for both carotid arteries and at one and two hours.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Massalha, S., Ferro, P., Ascah, K., Carey, C., Marvin, B., Dwivedi, G., Wells, R. G., Ravasi, L., Ruddy, T. Tags: Advances In Imaging of Atherosclerosis Source Type: research

Synthesis of 11CNR2B-SMe for evaluation as a PET radioligand for NR2B subunits in NMDA receptors
Conclusions: [11C]NR2B-SMe was readily synthesized, and showed high brain uptake in rat, which could be pre-blocked by NR2B-SMe itself, elipodil, ifenprodil, and by a selective sigma-1 receptor ligand. Because sigma-1 receptors serve as multitasking ion channel protein chaperones [4] with involvement in modulation of NMDA activity [5], and are now known to interact directly with the N-terminal domains of NR1 and NR2B subunits [6], further study is required to characterize the nature of the specific binding of [11C]NR2B-SMe in rat brain and its utility in brain research. These studies are ongoing. Research Support: Intramur...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C., Davies, R., Frankland, M., Zoghbi, S., Innis, R., Pike, V. Tags: Probes for Neuroimaging I Source Type: research

PET imaging of NPRC receptor using targeted nanoclusters in a mouse angiogenesis model
Conclusions: We have successfully synthesized and characterized the NPRC targeted 64CuAuNCs-CANF. The rapid blood clearance of 64CuAuNCs-CANF may allow earlier PET visualization of NPR-C receptor. Initial PET imaging in HLI model indicated the potential of 64CuAuNCs-CANF for further optimization and assessment of NPR-C targeting in pre-clinical models.Research Support: This work is supported by the Mallinckrodt Institute of Radiology Summer Research Program.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Sethi, A., Heo, G. S., Woodard, P., Liu, Y. Tags: Novel Radiochemistry & amp; Chelation Posters Source Type: research

Carotid artery atherosclerosis:plaque imaging in the personalized-medicine era
Conclusion: The evolution of atherosclerosis imaging and the emergence of new methods to measure atherosclerotic plaque vulnerability, particularly in the field of molecular imaging, have provided new insights into the pathophysiology of atherosclerosis and can be utilized in drug discovery and efficacy trials.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Gharavi, M., Saboury, B., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research