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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
ConclusionOur experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Characterization in nonhuman primates of (R)-18FOF-Me-NB1 and (S)-18FOF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor
ConclusionsIn rhesus monkeys, (R)-[18F]OF-Me-NB1 exhibited fast kinetics and heterogeneous uptake across brain regions, while the (S)-enantiomer displayed a narrower dynamic range of uptake across regions. A Blocking study with a GluN2B antagonist indicated binding specificity. The value ofBPND was  >  0.5 in most brain regions, suggesting goodin vivo specific binding signals. Taken together, results from the current study demonstrated the potential of (R)-[18F]OF-Me-NB1 as a useful radiotracer for imaging the GluN2B receptors.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 2, 2022 Category: Nuclear Medicine Source Type: research

Increased 68Ga-FAPI Uptake of Symptomatic Intracranial Atherosclerotic Plaque Revealed by PET/MR
A 58-year-old man was enrolled in our 68Ga-FAPI PET/MR study for evaluation of stroke etiology. He had left thalamus and cerebellum infarction 6 months ago, and left occipital lobe infarction 2 years ago. 68Ga-FAPI PET/MR showed focal uptake along the low segment of the basilar artery. We hypothesize that the FAPI-avid plaque of basilar artery may account for the embolic events resulting in downstream infarction. Thus FAP-targeted imaging may have a potential for detection of vulnerable plaques.
Source: Clinical Nuclear Medicine - April 11, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Atrial FDG uptake linked to ischemic stroke in patients without atrial fibrillation
Source: Journal of Nuclear Cardiology - April 26, 2022 Category: Nuclear Medicine Source Type: research

Echocardiographic indices of left ventricular function and filling pressure are not related to blood pool activity on pyrophosphate scintigraphy
ConclusionApproximately 8% of patients with a negative PYP SPECT have significant blood pool activity. Measures of cardiac function are not different among those with and without blood pool activity. PYP SPECT should be routinely performed in all patients to avoid false image interpretation.
Source: Journal of Nuclear Cardiology - May 16, 2022 Category: Nuclear Medicine Source Type: research

Crossed cerebellar diaschisis-related supratentorial hemodynamic and metabolic status measured by PET/MR in assessing postoperative prognosis in chronic ischemic cerebrovascular disease patients with bypass surgery
ConclusionsSupratentorial blood flow and metabolism are important indicators of CCD. This study showed that CCD  + patients benefited more from bypass surgery than CCD− patients. Staging based on CCD-related supra-tentorial blood flow and metabolic status by hybrid PET/MR may help to personalize treatment.
Source: Annals of Nuclear Medicine - July 5, 2022 Category: Nuclear Medicine Source Type: research

Left ventricular function and volumes from gated 13N-ammonia positron emission tomography myocardial perfusion imaging: A prospective head-to-head comparison against CMR using a hybrid PET/MR device
ConclusionLVEF and LV wall motion can be accurately assessed using [13N]-ammonia-PET MPI, although LV volumes are significantly underestimated compared to CMR.
Source: Journal of Nuclear Cardiology - July 11, 2022 Category: Nuclear Medicine Source Type: research

Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA
ConclusioncaIMR-derived CMD is associated with increased risk of MACE among INOCA patients. Patients with abnormalities on both caIMR and MPI had the worse outcomes.Graphical abstract
Source: Journal of Nuclear Cardiology - August 2, 2022 Category: Nuclear Medicine Source Type: research

Correlation of Global and Regional Amyloid Burden by 18F-Florbetaben PET/CT With Cognitive Impairment Profile and Severity
Conclusion Semiquantitative analysis of amyloid PET by SUVR values revealed a significant correlation between amyloid burden and CI severity, although only in women.
Source: Clinical Nuclear Medicine - October 17, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The prognostic value of CZT SPECT myocardial blood flow (MBF) quantification in patients with ischemia and no obstructive coronary artery disease (INOCA): a pilot study
ConclusionThe preliminary results demonstrated that quantitative analysis on CZT SPECT provides prognostic value for INOCA patients, which may allow the stratification for early prevention and intervention.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 14, 2023 Category: Nuclear Medicine Source Type: research