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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist
Conclusion: The tetraazamacrocyclic small molecule 64Cu-CuCB-bicyclam has been shown to be an imaging agent for the CXCR4 receptor that is likely to be applicable across a range of species. It has high affinity and stability and is suitable for preclinical research in immunocompetent murine models.
Source: Journal of Nuclear Medicine - January 1, 2020 Category: Nuclear Medicine Authors: Burke, B. P., Miranda, C. S., Lee, R. E., Renard, I., Nigam, S., Clemente, G. S., DHuys, T., Ruest, T., Domarkas, J., Thompson, J. A., Hubin, T. J., Schols, D., Cawthorne, C. J., Archibald, S. J. Tags: Basic Source Type: research

Initial experience with 18 FDPA-714 TSPO-PET to image inflammation in primary angiitis of the central nervous system
Conclusions[18F]DPA-714-PET imaging may facilitate the diagnosis and treatment monitoring of PACNS. Further studies are needed to fully understand the potential of TSPO-PET in deciphering the heterogeneity of the disease.
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 19, 2020 Category: Nuclear Medicine Source Type: research

Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.
Authors: Heo GS, Sultan D, Liu Y Abstract Cardiovascular disease (CVD) remains the leading cause of death worldwide despite advances in diagnostic technologies and treatment strategies. The underlying cause of most CVD is atherosclerosis, a chronic disease driven by inflammatory reactions. Atherosclerotic plaque rupture could cause arterial occlusion leading to ischemic tissue injuries such as myocardial infarction (MI) and stroke. Clinically, most imaging modalities are based on anatomy and provide limited information about the on-going molecular activities affecting the vulnerability of atherosclerotic lesion for...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Clinical imaging of cardiovascular inflammation.
Authors: Calcagno C, Fayad ZA Abstract Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in the development of atherosclerosis initiation and progression in the vasculature, all the way to the onset of life-threatening cardiovascular events. Furthermore, inflammation is key to heart and brain damage and healing after myocardial infarction or stroke. Recent evidence indicates that this interplay between the vasculatur...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Pet tracers for vulnerable plaque imaging
AbstractMost of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipid core, and micro-calcifications. Early detection of the presence of a plaque prone to rupture could be life-saving for the patient; however, vulnerable plaques usually cause non-haemodynamically significant stenosis, and anatomical imaging techniques often underestimate, or may not even detect, these ...
Source: Annals of Nuclear Medicine - March 19, 2020 Category: Nuclear Medicine Source Type: research

18F-FDG PET/CT Brain in a Case of Agrammatic/Nonfluent Variant of Primary Progressive Aphasia (Broca’s Aphasia)
We present a case of middle-aged female patient who underwent 18F-FDG PET of the brain for evaluating progressively declining speaking ability associated with altered fluency of speech and occasional mutism. 18F-FDG PET revealed asymmetric hypometabolism involving the left inferior frontal gyrus along with left anterior cingulate gyrus suggestive of Broca's aphasia.
Source: Clinical Nuclear Medicine - April 15, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis
Conclusion: 18F-FAC PET can visualize brain-infiltrating leukocytes in a mouse MS model and can monitor the response of these cells to an immunomodulatory drug. Translating this strategy into humans will require exploring additional radiotracers.
Source: Journal of Nuclear Medicine - April 30, 2020 Category: Nuclear Medicine Authors: Chen, B. Y., Ghezzi, C., Villegas, B., Quon, A., Radu, C. G., Witte, O. N., Clark, P. M. Tags: Basic Source Type: research

The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score
Conclusions Random forests help pinpoint clinically relevant ROIs associated with MoCA score; amyloid increased and 18F-FDG decreased with decreasing MoCA score, most significantly in the posterior cingulate gyrus.
Source: Clinical Nuclear Medicine - May 8, 2020 Category: Nuclear Medicine Tags: Original Article Source Type: research

Nr2b
Conclusions: The 1 receptor-selective radioligand [18F]FTC146 was used in PET imaging of rat brain. It showed high brain uptake, which could be pre-blocked by self, a 1 receptor ligand BD1047, and a NR2B-selective ligand NR2B-SMe, but at markedly different ED50 values. The ED50 for avidly brain-penetrant NR2B-SMe gave by far the highest value, implying only weak interaction with 1 receptors. Influence of 1 receptors on the PET imaging of NR2B receptors with [11C]NR2B-SMe is therefore likely negligible. Research Support: Intramural Research Program of the National Insitutes of Health (NIMH). References: [1] Zhuo M, Neuropha...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C., Davies, R., Manly, L., Zoghbi, S., Innis, R., Pike, V. Tags: Basic Science - Synaptic activity and other mechanisms Source Type: research

Crossed cerebellar diaschisis on 18F-FDG PET across neurodegenerative diseases: frequency and association with 11C-PIB and 18F-FTP
Conclusions: CCD is present in a significant proportion of patients with neurodegenerative diseases, and is more prevalent in specific phenotypes, especially in typically asymmetric presentations such as CBS, svPPA and lvPPA. The association between CCD on 18F-FDG and cortical 18F-FTP suggests a Tau-related disruption of cortico-ponto-cerebellar pathways in amyloid-positive patients, while amyloid does not seem to play a significant role. Further studies are required to elucidate prognostic value or clinical correlate of CCD. Table 1. Patient characteristics and prevalence of crossed cerebellar diaschisis (CCD) by diagnosi...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Provost, K., Strom, A., Iaccarino, L., Edwards, L., Mellinger, T., Pham, J., Baker, S., Miller, B., Jagust, W., La Joie, R., Rabinovici, G. Tags: Neurodegenerative Diseases Source Type: research

Correlation between inflammation and neovascularization in carotid atherosclerotic plaques based on hybrid 18F-FDG PET/MRI: a pathological validation study
Conclusions: The correlation between inflammation and neovascularization in carotid atherosclerotic plaques with hybrid 18F-FDG PET/MR varied with clinical conditions, pointing to a complex interplay between macrophages and neovessels under different pathophysiological conditions. Hybrid 18F-FDG PET/MR systems can help to evaluate the correlation between inflammation and neovascularization in carotid atherosclerotic plaques. Key words: Atherosclerosis, Vulnerable plaque, Inflammation, Neovascularization, Hybrid PET/MR.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Zhang, Y., Lu, J., Yang, H., Ma, J., Song, H., Ma, Q. Tags: Radionuclide Imaging of Atherosclerosis Source Type: research

Potential applications of FDG-PET/MRI in detecting vascular dementia
Conclusions: FDG-PET/MRI may be a valuable tool in the diagnosis of VaD. However, the paucity of data in the field necessitates a further analysis of its similarity to FDG-PET/CT in results. Novel studies should be conducted to explore various scanners, patient populations, and MRI protocols to better inform the identification of VaD.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Bhattaru, A., Zhang, V., Hancin, E., Borja, A., Rojulpote, K. V., Werner, T., Revheim, M.-E., Alavi, A. Tags: Educational Exhibits Poster Session I Source Type: research

F-18 FDG PET/CT in Management of Necrotizing Otitis Externa
1157Objectives: Necrotizing otitis externa (NOE), also referred to as "malignant otitis externa," is an uncommon complication of external ear canal infections, resulting in skull base osteomyelitis. Multiple pathogens have been implicated, the most common of which is Pseudomonas aeruginosa. Risk factors include diabetes, advanced age, and immunocompromised status. Clinical features include unremitting otalgia, otorrhea, headache, and cranial nerve involvement. Treatment consists of prolonged parenteral antibiotics and selective surgical debridement. Inadequate treatment of NOE is associated with significant morbidities, in...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Thorsness, S., Friedman, N., Moore, D., Cohen, E., Reddy, S. Tags: Educational Exhibits Poster Session I Source Type: research

Value of SPECT/CT over planar imaging during Tc-99m MDP triple phase bone scintigraphy for detection of osteomyelitis in patients with stage IV pressure ulcers
Conclusion: SPECT/CT imaging has a significant added diagnostic value over planar imaging in accurately detecting osseous involvement with stage IV pressure ulcers. It significantly reduced equivocal results by accurate uptake localization, reducing false positive results due to other associated pathologies and reducing false negative results due to overlap by other structures or difficult patient positioning.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Nasr, H., Alfawzan, T., Alqarni, A., Farghaly, H. Tags: Infection/Pulmonary/Outcomes (Poster Session) Source Type: research

Assessing the pharmacokinetics and metabolism of 18FLMI1195 in clinical imaging populations
Conclusions: These preliminary results suggest notable differences in the clearance and metabolic profiles of [18F]LMI1195 dependent on the given disease pathology. Radiotracer parent fraction can be equally measured by column-switching HPLC or SPE. These findings offer an important consideration for estimation of myocardial sympathetic nerve density using [18F]LMI1195 in patients suffering from cardiovascular disease. Support: Heart & Stroke Foundation of Canada/CANet ERLI (Rotstein) References: [1] Zelt, J. G. E. et al. J. Nucl. Cardiol. 2019, 26 (6), 2151-2153. [2] Sinusas, A. J. et al. J. Nucl. Med. 2014, 55 (9), 1...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Mair, B., Al Haddad, R., Zelt, J., Dinelle, K., Quigley, S., Beanlands, R., DeKemp, R., Rotstein, B. Tags: Clinical Science (Poster Session) Source Type: research