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Total 25977 results found since Jan 2013.

Determinants and Temporal Trends of Dual Antiplatelet Therapy After Mild Noncardioembolic Stroke
CONCLUSIONS: Despite a temporal trend increase in DAPT prescription after mild NCIS, we found substantial underutilization of evidence-based DAPT associated with significant disparities in stroke care.PMID:37675611 | DOI:10.1161/STROKEAHA.123.043769
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Victor J Del Brutto Ruijie Yin Hannah Gardener Hao Ying Carolina M Gutierrez Angus M Jameson David Z Rose Ayham Alkhachroum Dianne Foster Chuanhui Dong Selina Ancheta Nicole B Sur Gillian Gordon Perue Tatjana Rundek Negar Asdaghi Ralph L Sacco Jose G Roma Source Type: research

Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research

EP News Clinical
Kirchof and colleagues (N Engl J Med. 2003; epub Aug. 25: PMID: 37622677) conducted a, double-blind, double-dummy, randomized trial of patients> 65 years with device-detected atrial high-rate episodes (AHREs)> 6 minutes. Patients were randomized to edoxaban (E) or placebo (P). The primary efficacy outcome was a composite of cardiovascular death, stroke, or systemic embolism. The safety outcome was a composite of death from any cause or major bleeding. Overall, 2536 patients were randomized, including 1270 to E and 1266 to P.
Source: Heart Rhythm - September 7, 2023 Category: Cardiology Authors: N. A. Mark Estes Source Type: research

EP News: Clinical
Kirchof et al (N Engl J Med August 25, 2003; https://doi.org/10.1056/NEJMoa2303062, PMID 37622677) conducted a double-blind, double-dummy, randomized trial of patients 65 years and older with device-detected atrial high-rate episodes lasting for ≥6 minutes. Patients were randomized to edoxaban (E) or place bo (P). The primary efficacy outcome was a composite of cardiovascular death, stroke, or systemic embolism. The safety outcome was a composite of death from any cause or major bleeding. Overall, 2536 patients were randomized, including 1270 to E and 1266 to P.
Source: Heart Rhythm - September 7, 2023 Category: Cardiology Authors: N.A. Mark Estes Tags: EP NEWS Source Type: research

Heightened risk of ischemic stroke and mortality in takotsubo syndrome: A function of what?
To the Editor:
Source: International Journal of Cardiology - September 6, 2023 Category: Cardiology Authors: John E. Madias Tags: Letter to the Editor Source Type: research

Long-term efficacy and safety of early alogliptin initiation in subjects with type 2 diabetes: an extension of the SPEAD-A study
Sci Rep. 2023 Sep 5;13(1):14649. doi: 10.1038/s41598-023-41036-1.ABSTRACTWe previously reported in the study of preventive effects of alogliptin on diabetic atherosclerosis (SPEAD-A) that alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, attenuated the progression of carotid atherosclerosis in subjects with type 2 diabetes and no history of cardiovascular disease. This extension study of the SPEAD-A trial investigated whether early alogliptin initiation improved long-term cardiovascular outcomes. The SPEAD-A trial randomized 341 subjects with type 2 diabetes to either alogliptin or conventional treatment to investiga...
Source: Atherosclerosis - September 5, 2023 Category: Cardiology Authors: Tomoya Mita Naoto Katakami Hidenori Yoshii Tomio Onuma Hideaki Kaneto Takeshi Osonoi Toshihiko Shiraiwa Tetsuyuki Yasuda Yutaka Umayahara Tsunehiko Yamamoto Hiroki Yokoyama Nobuichi Kuribayashi Hideaki Jinnouchi Masahiko Gosho Iichiro Shimomura Hirotaka W Source Type: research

Direct Oral Anticoagulants: Patients Benefit When Prescribers Get the Message
Direct oral anticoagulants (DOACs) have demonstrated similar or better efficacy to warfarin in reducing stroke and systemic embolic events in large-scale prospective trials.1 –4 In addition, these trials demonstrated either noninferiority or superiority in reducing bleeding events compared with warfarin. To treat high-risk patients with atrial fibrillation (AF) and avoid bleeding in low-risk patients, current guidelines recommend oral anticoagulants in high-risk patien ts with AF with CHA2DS2VASc scores of ≥2 in men and ≥3 in women.
Source: The American Journal of Cardiology - September 5, 2023 Category: Cardiology Authors: Gerald V. Naccarelli Tags: Editorial Source Type: research

Prediction of the 4-Year Incidence Risk of Ischemic Stroke in Healthy Japanese Adults: The Fukushima Health Database
CONCLUSIONS: The 4-year risk prediction model revealed a good performance for IS incidence, and risk scores could be used to estimate individual incidence risk of IS. Updated models with additional confirmed risk variables may be needed.PMID:37661424 | DOI:10.5551/jat.64018
Source: Journal of Atherosclerosis and Thrombosis - September 4, 2023 Category: Cardiology Authors: Enbo Ma Tetsuya Ohira Makoto Miyazaki Maiko Fukasawa Masayo Yoshimoto Tomonori Suzuki Ayako Furuyama Mariko Kataoka Seiji Yasumura Mitsuaki Hosoya Source Type: research

Genetic Polymorphism Detection of Pathophysiological Pathways of Ischemic Stroke in Asian
This study aims to summarize specific variants relevant to Asian populations that may aid in the early detection of ischemic stroke and explore their impact on the disease's pathophysiology. These variants give us important information about the genes that play a role in ischemic stroke by affecting things like atherosclerosis pathway, blood coagulation pathway, homocysteine metabolism, transporter function, transcription, and the activity of neurons regulation. It is important to recognize the variations in genetic variants among different ethnicities and avoid generalizing the pathogenesis of ischemic stroke.PMID:3766638...
Source: Atherosclerosis - September 4, 2023 Category: Cardiology Authors: Valentinus Besin Trilis Yulianti Paulus Budiono Notopuro Farizky Martriano Humardani Source Type: research

Associations between eGFR and albuminuria with right ventricular measures: the MESA-Right Ventricle study
CONCLUSIONS: Among community-dwelling adults, reductions in eGFR primarily within the normal range were associated with smaller RV volumes and the association of albuminuria with worse survival was stronger among those with smaller RV volumes. Further studies are needed to elucidate the underlying mechanistic pathways that link kidney measures and RV morphology.PMID:37664568 | PMC:PMC10469092 | DOI:10.1093/ckj/sfad096
Source: Atherosclerosis - September 4, 2023 Category: Cardiology Authors: Faeq Husain-Syed Matthew F DiFrancesco Rajat Deo R Graham Barr Julia J Scialla David A Bluemke Richard A Kronmal Joao A C Lima Amy Praestgaard Russell P Tracy Michael Shlipak Steven M Kawut John S Kim Source Type: research

Microfluidic-to-macrofluidic: A simple < em > in vitro < /em > model of atherosclerosis induced by fluidic stimulation
Biomicrofluidics. 2023 Aug 29;17(4):044106. doi: 10.1063/5.0155267. eCollection 2023 Jul.ABSTRACTAtherosclerosis is the narrowing of the arteries due to the formation of fatty plaques, which is the main cause of myocardial infarction and stroke. It is important to develop an in vitro model that can combine multiple-type cell co-culture, vessel wall-like structure, and fluid condition to simulate the processes of atherosclerosis. Herein, we used a simple microfluidic chip made of three polydimethylsiloxane layers to co-culture endothelial and smooth muscle cells in a flat rectangular microchannel. After being connected with...
Source: Atherosclerosis - September 4, 2023 Category: Cardiology Authors: Jingang Cui Wei Jiang Jilei Su Jiazhen Zhang Yongliang Yu Yongsheng Ding Source Type: research

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