Filtered By:
Therapy: Vagus Nerve Stimulation Therapy

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 158 results found since Jan 2013.

Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke
Conclusion Our data suggest that the neuroprotective role of a series of nVNS administrations during MCA occlusion, spatially correlates with protection of BBB integrity from damage and reduction of infarct extent induced by ischemic stroke.
Source: Brain Stimulation - February 16, 2018 Category: Neurology Source Type: research

Cholinergic anti-inflammatory pathway and stroke.
Abstract Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and α7 nicotinic acetylcholine receptor (α7 nAChR) are the main components of CHAIP. Targeting cholinergic anti-inflammatory pathway is a promisin...
Source: Current Drug Delivery - January 31, 2017 Category: Drugs & Pharmacology Authors: Duris K, Lipkova J, Jurajda M Tags: Curr Drug Deliv Source Type: research

L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
This study investigated the role of L-PGDS in cerebral I/R and whether this process was involved in the mechanism of VNS-mediated neuroprotection. Male Sprague-Dawley rats were pretreated with a lentiviral vector (LV) through intracerebroventricular injection, followed by middle cerebral artery occlusion (MCAO) and VNS treatment. The expression of L-PGDS in the peri-infarct cortex was examined. The localization of L-PGDS was determined using double immunofluorescence staining. Neurologic scores, infarct volume and neuronal apoptosis were evaluated at 24 h after reperfusion. The expression of apoptosis-related molecules wa...
Source: Neurochemical Research - November 28, 2016 Category: Neuroscience Authors: Zhang L, Ma J, Jin X, Jia G, Jiang Y, Li C Tags: Neurochem Res Source Type: research

Vagus Nerve Stimulation and Upper Limb Rehabilitation
This article will review the evidence for the use of vagus nerve stimulation to drive the growth of new neural pathways during upper limb rehabilitation and improve functional recovery after stroke.Recent FindingsApproximately 85  % of patients with stroke present with arm weakness and 60 % of stroke survivors with poorly functioning arms at 1 week do not recover meaningful function by 6 months. The mainstay of current treatment is intensive, task-specific and repetitive rehabilitation therapy or occasionally methods suc h as constraint-induced movement therapy and robotic therapy. The effects of these treatments are m...
Source: Current Physical Medicine and Rehabilitation Reports - July 31, 2016 Category: Rehabilitation Source Type: research

Vagus Nerve Stimulation During Rehabilitative Training Improves Forelimb Recovery After Chronic Ischemic Stroke in Rats
Conclusion. VNS paired with rehabilitative training confers significantly greater recovery of forelimb function after chronic ischemic stroke in rats.
Source: Neurorehabilitation and Neural Repair - July 10, 2016 Category: Neurology Authors: Khodaparast, N., Kilgard, M. P., Casavant, R., Ruiz, A., Qureshi, I., Ganzer, P. D., Rennaker, R. L., Hays, S. A. Tags: Basic Research Articles Source Type: research

Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats.
Abstract Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength. Once proficient, rats receiv...
Source: Neurobiology of Aging - June 4, 2016 Category: Geriatrics Authors: Hays SA, Ruiz A, Bethea T, Khodaparast N, Carmel JB, Rennaker RL, Kilgard MP Tags: Neurobiol Aging Source Type: research

Vagus Nerve Stimulation during Rehabilitative Training Enhances Recovery of Forelimb Function after Ischemic Stroke in Aged Rats
Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury, but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength.
Source: Neurobiology of Aging - April 6, 2016 Category: Neuroscience Authors: Seth A. Hays, Andrea Ruiz, Thelma Bethea, Navid Khodaparast, Jason B. Carmel, Robert L. Rennaker, Michael P. Kilgard Source Type: research

Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia/ reperfusion rat model
Publication date: Available online 8 March 2016 Source:Neurochemistry International Author(s): Ying Jiang, Longling Li, Jingxi Ma, Lina Zhang, Fei Niu, Tao Feng, Changqing Li Electrical stimulation of the vagus nerve, which has been used to treat epilepsy patients since 1997, also enhances long-term restoration after central nervous system (CNS) injury. Angiogenesis is a complex restorative mechanism that occurs in response to ischemic stroke, and it positively affects the recovery of neurological functions in a rat model of stroke. The aims of our study were to determine whether auricular vagus nerve stimulation ...
Source: Neurochemistry International - March 8, 2016 Category: Neuroscience Source Type: research

Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke Clinical Sciences
Conclusions— This study suggests that VNS paired with rehabilitation is feasible and has not raised safety concerns. Additional studies of VNS in adults with chronic stroke will now be performed. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01669161.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Dawson, J., Pierce, D., Dixit, A., Kimberley, T. J., Robertson, M., Tarver, B., Hilmi, O., McLean, J., Forbes, K., Kilgard, M. P., Rennaker, R. L., Cramer, S. C., Walters, M., Engineer, N. Tags: Exercise, Rehabilitation, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation
Abstract Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one ...
Source: Neurotherapeutics - December 15, 2015 Category: Neurology Source Type: research

Vagus nerve stimulation shows progress in stroke patient recovery
Vagus nerve stimulation (VNS) technology could help improve the lives of hundreds of thousands of people who suffer weakness and paralysis caused by strokes, new research suggests. The study marks the first time that VNS has been tested in individuals recovering from stroke.
Source: ScienceDaily Headlines - December 9, 2015 Category: Science Source Type: news

Transcutaneous Cervical Vagus Nerve Stimulation Ameliorates Acute Ischemic Injury in Rats
Conclusions nVNS inhibits ischemia-induced immune activation and reduces the extent of tissue injury and functional deficit in rats without causing cardiac or hemodynamic adverse effects when initiated up to 4 hours after MCAO.
Source: Brain Stimulation - December 1, 2015 Category: Neurology Source Type: research

Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015: Summary of PMA Originals & Supplements Approved Originals: 2 Supplements: 70 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 28 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 569 Total Active: 422 Total On Hold: 147 Summary of All PMA Submissions Originals: 5 Supplements: 90 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 70 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 229.0 FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news