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Total 451 results found since Jan 2013.

Intravascular lymphoma mimicking vasculitis
This report documents the presence of intravascular lymphoma diagnosed on a brain biopsy in a 60-year-old man. He initially presented 6months before brain biopsy with chest pain and hypotension, warranting coronary artery bypass graft surgery. Four months later, he presented with signs attributed to a stroke (diaphoresis, slumped over in a chair and left hand weakness). He subsequently developed a sudden onset wide-based gait, left leg numbness, word finding difficulties and worsening confusion. A MRI study showed multiple infarcts in the brain, including cerebellum. Invasive angiogram suggested vasculitis. He was started ...
Source: Journal of Clinical Neuroscience - November 10, 2016 Category: Neuroscience Source Type: research

A sirtuin activator and an anti-inflammatory molecule —multifaceted roles of adjudin and its potential applications for aging-related diseases
Publication date: November 2016 Source:Seminars in Cell & Developmental Biology, Volume 59 Author(s): Weiliang Xia, Keyi Geng Adjudin was originally developed as an improved analog of lonidamine to serve as a non-hormonal reversible male contraceptive that could cause exfoliation of the immature sperms from the seminiferous epithelium. Recently, the functionality spectrum of adjudin expands beyond as an anti-spermatogenic agent, namely, it could function as an anti-cancer drug potentially useful for combination chemotherapy, and as an anti-inflammatory molecule that could protect against ischemic stroke injury. Mo...
Source: Seminars in Cell and Developmental Biology - November 23, 2016 Category: Cytology Source Type: research

Reflections on the Future of Medicine
Recently, I traveled through China. I climbed mountains, hiked through forests, crossed deep valleys. I visited cities of every size. I floated across lakes and traveled beautiful shorelines churning with life. As a man of a certain age, I began to compare the permanence of the timeless landscape with the evanescence of my own existence. Yet, as a scientist, I knew these reflections were flawed. Scientists are trained to think in terms of aeons, millenia, and lifetimes. Consider the paradox. Is it the solid mountain or fragile the forest that is permanent? Is it the massive shoreline cliffs or the teeming shore life that...
Source: Science - The Huffington Post - January 9, 2017 Category: Science Source Type: news

Sustaining and Improving Current Practices Surrounding Timely Hypertension Management in Pediatric Hematopoietic Stem Cell Patients
Topic Significance& Study Purpose/Background/Rationale: Hypertension (HTN) is a known complication during pediatric hematopoietic stem cell transplant (HSCT). The risks for developing hypertension depend on a variety of factors including the use of drugs (calcineurin inhibitors, steroids, and chemotherapy), total body irradiation (TBI), renal injury, transplant associated thrombotic microangiopathy (TMA) and sinusoidal obstructive syndrome (SOS). Uncontrolled HTN may lead to significant life-threatening complications including impaired renal and heart function, stroke, posterior reversible encephalopathy (PRES) and death.
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Michelle Lewyckyj, Adam S. Nelson, Christopher E. Dandoy, Ashley Teusink, Sonata Jodele, Laura Flesch Source Type: research

Exercise 'most proven method' to prevent return of breast cancer
Conclusion This was a helpful summary of recent research into how lifestyle changes impact on the risk of breast cancer returning, but it does have some limitations. Researching lifestyle factors separately is always difficult as they tend to clump together, making it difficult to pick apart individual factors. For example, people who are more physically active tend to have a healthier diet and are less likely to drink excessive amounts of alcohol or smoke. While the researchers say many studies attempt to make adjustments for these confounding factors, it is difficult to know which studies did this and how successful they...
Source: NHS News Feed - February 22, 2017 Category: Consumer Health News Tags: Cancer QA articles Lifestyle/exercise Source Type: news

Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database.
CONCLUSIONS: These findings obtained from healthcare database suggest predictors either for recurrent VTE and bleeding that should be considered when selecting treatment to reduce the risk of recurrent VTE and mitigate bleeding. PMID: 28245956 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 24, 2017 Category: Cardiology Authors: Nakamura M, Yamada N, Oda E, Matsubayashi D, Ota K, Kobayashi M, Matsushita Y, Kaburagi J, Ibusuki K, Takita A, Iwashita M, Yamaguchi T Tags: J Cardiol Source Type: research

Fatal Folic Acid Toxicity in Humans.
Abstract Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingestion of a large dose of folic acid generally manifests as neurological complications, which are reversible. In this present case, a 23-year-old pregnant woman committed suicide by consuming folic acid tablets and succumbed to death within 36 h. Postmortem toxicological analysis detected folic acid in viscera. Death following acute consumption of folic aci...
Source: Journal of Forensic Sciences - March 5, 2017 Category: Forensic Medicine Authors: Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A Tags: J Forensic Sci Source Type: research

A Case of Posterior Reversible Encephalopathy Syndrome Induced by Cisplatin/Pemetrexed Chemotherapy for Lung Cancer
This report presents the case of a 60-year-old woman who was diagnosed with stage IV lung adenocarcinoma with asymptomatic brain metastases and commenced chemotherapy with cisplatin/pemetrexed (CDDP/Pem). She experienced tonic-clonic convulsions on day 9 of the first cycle, which were accompanied by increased blood pressure (173/69 mm Hg) and headache. Therefore, brain MRI was performed to check for stroke or progression of brain metastatic foci. T2-weighted, FLAIR, and ADC map images showed high-intensity areas in the subcortical region of the bilateral parieto-occipital lobes, leading to a diagnosis of posterior reversib...
Source: Case Reports in Oncology - March 9, 2017 Category: Cancer & Oncology Source Type: research

Fatal folic acid toxicity in humans - Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A.
Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingest...
Source: SafetyLit - March 11, 2017 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
Nature advance online publication 13 March 2017. doi:10.1038/nature21414 Authors: Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A. Koteiche, Robert K. Nakamoto, Emad Tajkhorshid & Hassane S. Mchaourab ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD). Although numerous investigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC exporters, a detailed structural...
Source: Nature AOP - March 12, 2017 Category: Research Authors: Brandy Verhalen Reza Dastvan Sundarapandian Thangapandian Yelena Peskova Hanane A. Koteiche Robert K. Nakamoto Emad Tajkhorshid Hassane S. Mchaourab Tags: Letter Source Type: research

Cheap stroke drug boosts pancreatic cancer survival in mice
A drug used in Asia for decades to treat strokes has been found to soften the armour of pancreatic tumours, making them vulnerable to chemotherapy
Source: New Scientist - Health - April 5, 2017 Category: Consumer Health News Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Vestibulocochlear nerve dysfunction as initial manifestation of Waldenstrom Macroglobulinemia (P5.193)
Conclusions:Clinical findings from this case demonstrated early vascular complications of multiple peripheral neurosensory systems secondary to WM-related hyperviscosity. Early recognition of symptoms through detailed history taking and neurological examination is necessary for a correct diagnosis and better outcome.Disclosure: Dr. Humayun has nothing to disclose. Dr. Panjwani has nothing to disclose. Dr. Li has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Humayun, M., Panjwani, S., Li, H. Tags: Neuro-ophthalmology/Neuro-otology I Source Type: research

Neurologic manifestations of geriatric patients with cancer (P6.188)
Conclusions:Neurologic manifestations are reported in about 40% of patients with cancer, approximately half of living patients with cancer are over 65 years of age, this increase merits the medical and related personnel to be prepared and recognize, diagnose and treat this highly morbid conditions. Neurologic manifestations and diagnoses in patients with cancer are different in the elderly and should be treated individually; the present work offers information regarding clinical symptoms and neurologic diagnoses in this population.Disclosure: Dr. Cacho Diaz has nothing to disclose. Dr. Lorenzana-Mendoza has nothing to disc...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Diaz, B. C., Lorenzana-Mendoza, N., Soto, G. R., Gomez, A. H. Tags: Neurologic Complications of Cancer Source Type: research