Reflections on the Future of Medicine

Recently, I traveled through China. I climbed mountains, hiked through forests, crossed deep valleys. I visited cities of every size. I floated across lakes and traveled beautiful shorelines churning with life. As a man of a certain age, I began to compare the permanence of the timeless landscape with the evanescence of my own existence. Yet, as a scientist, I knew these reflections were flawed. Scientists are trained to think in terms of aeons, millenia, and lifetimes. Consider the paradox. Is it the solid mountain or fragile the forest that is permanent? Is it the massive shoreline cliffs or the teeming shore life that survives the relentless churning of our continents? The answer is not intuitive. Over time the mountain will crumble, the sea will flow to the hollow, the mountain will rise again. Wherever there is a mountain, a forest will flourish. Wherever there is a sea, life will abound. It is not the rock and water that are everlasting. It is life that abides. Life is immortal. Each one of us is a direct, living descendent of the first living forms that arose four billion years ago, when our planet was still being shaped by bombardment from the heavens. Inheritance is a fundamental characteristic of life. One cell divides into two. Those two cells give rise to others. The DNA molecule within each cell drives cell duplication, dividing and replicating to form nearly identical versions of itself. The molecule resides in each and every one of our cells. It is the cumu...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Publication date: February 2019Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 55Author(s):
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
ConclusionsWe found the precise anatomy of the connective tissue layer from umbilical artery to urinary bladder and the superior vesical artery. Our procedure based on the precise anatomy obtained in this study is reasonable anatomically as a method for separation of the vesicouterine ligament during radical hysterectomy.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
This study investigated the modulation of micro-RNAs associated with the PI3K/AKT/mTOR-axis by mango polyphenols (MP) in MCF-12A non-cancer and MDA-MB231 breast cancer cell lines. MP reduced proliferation in the cancer cells by up to 90% (10 mg GAE/L) but did not cause cytotoxicity in the non-cancer cells within the same concentration range. In contrast, in TNF-α-treated non-cancer MCF-12A cells, MP significantly decreased expression and phosphorylation of NF-κB while modulating mRNA and protein levels of PI3K/AKT/mTOR and up-regulated miR-126. The mechanistic involvement of miR-126 was investigated using its...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
In this study, Se-enriched peanut protein nanoparticles-stabilized Pickering emulsions (PPEs) were used to encapsulate 5DN to enhance its bioaccessibility, cellular uptake and transport rate. The preparation of PPEs, and their digestion profiles in gastrointestinal tract, cell uptake and transport were investigated. Results showed that the bioaccessibility of 5DN was significantly higher within PPEs (18.3%) than in bulk oil (9.2%). Besides, PPEs-encapsulated 5DN has a greater apical-to-basolateral (AP-BL) transport rate (26.9 × 10−6 cm s−1) than 5DN (21.7 × 10−6 cm s−1). ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: April 2019Source: Journal of Functional Foods, Volume 55Author(s): Chia-Yuan Chang, Bing-Ying Ho, Tzu-Ming PanAbstractColorectal cancer (CRC) is a major cause of cancer-related deaths worldwide. Chemotherapy is the usual treatment, but entails side effects. Although lactic acid bacteria (LAB) ameliorate CRC, the effects of LAB-fermented skim milk are unknown. Thus, we investigated the effect of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skim milk (NTU 101FM) in combination with chemotherapy on CRC, and its effect on chemotherapeutic side effects in vivo. NTU 101FM + chemotherapy treatm...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 1 February 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Mohamed E. Awad, Amara Altman, Radwa Elrefai, Peter Shipman, Stephen Looney, Mohammed ElsalantyAbstractBackgroundVascularized fibular flaps are considered the gold standard for the reconstruction of segmental defects in the mandible. This review compares the complication and success rates of these techniques between primary and secondary reconstruction, as well as between lateral and antero-lateral defects.Type of studies reviewedA systematic review and meta-analysis were conducted according to PRISMA protocol and th...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionsTiming for oral rehabilitation may differ depending on the treatment modality followed for mandibular tumors in the patient with oral cancer. However, most patients in this cohort underwent rehabilitation with removable mandibular resection prostheses regardless of the timing of care. Endosseous implants were used infrequently, but research is needed to better understand their potential role and indication in the patient with oral cancer.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
ConclusionRb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mammalian target of rapamycin signaling and inducing myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Here ’s what most medical experts agree on: People 50 and older should be screened for colon cancer. Here’s what is more controversial: Whether that screening should start, routinely, at age 45. Recently, the American Cancer Society (ACS) recommended that colon cancer screenings start at age 45. The ir recommendation was based in large part on an uptick […]Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
ConclusionThe SAFB MFI and T-FCXM ratio, both semi-quantitative parameters, only partially reflected the subtlety of the anti-HLA antibody/antigen interaction as it can be analyzed by SPR. Future clinical studies using SPR for anti-HLA antibodies characterization could bring novel insights into the understanding of HLA/anti-HLA interaction and therefore anti-HLA antibodies pathogenicity.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
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