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When Can A Child Start Strength Training?
Discussion Exercise is an important part of health and daily life. A review of recommendations for general exercise for children and adults can be found here. Many people use pedometers as a marker of their activity and a list of activities and their equivalent steps can be found here. The benefits of strength training includes improved performance, injury prevention and rehabilitation, improved cardiovascular fitness, improved bone mineral density, improved blood lipid profiles and mental health. Improvements in strength can be found in properly structured programs of at least 8 weeks duration occurring at least 1-2 time...
Source: PediatricEducation.org - May 12, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Managing Chemotherapy-Related Cardiotoxicity in Survivors of Childhood Cancers.
Abstract In the US, children diagnosed with cancer are living longer, but not without consequences from the same drugs that cured their cancer. In these patients, cardiovascular disease is the leading cause of non-cancer-related morbidity and mortality. Although this review focuses on anthracycline-related cardiomyopathy in childhood cancer survivors, the global lifetime risk of other cardiovascular diseases such as atherosclerosis, arrhythmias and intracardiac conduction abnormalities, hypertension, and stroke also are increased. Besides anthracyclines, newer molecularly targeted agents, such as vascular endothel...
Source: Paediatric Drugs - August 19, 2014 Category: Pediatrics Authors: Lipshultz SE, Diamond MB, Franco VI, Aggarwal S, Leger K, Santos MV, Sallan SE, Chow EJ Tags: Paediatr Drugs Source Type: research

The Tell-Tale Heart: Molecular and Cellular Responses to Childhood Anthracycline Exposure.
Abstract Since the modern era of cancer chemotherapy that began in the mid 1940's, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80%. Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are afflicted with a severe or life-threatening medical condition, with cardiovascular disease being a primary risk. Childhood cancer survivors have markedly elevated incidences of stroke, congestive heart failure (CHF), coronary artery disease (CAD), and valvular disease. Their cardiac mortality is 8.2 times ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 12, 2014 Category: Physiology Authors: Lindsey ML, Lange RA, Parsons H, Andrews T, Aune GJ Tags: Am J Physiol Heart Circ Physiol Source Type: research

Primary Ovarian Insufficiency
Abstract Primary ovarian insufficiency (POI) is a syndrome of amenorrhoea, sex steroid deficiency, and elevated gonadotropins in a woman aged more than two standard deviations below the mean age for menopause estimated for her reference population. In practical terms, it occurs spontaneously in 1 % of women before the age of 40 years. Apart from idiopathic POI, many women will have impaired ovarian function by age 40 years as a consequence of surgery, chemotherapy, or radiotherapy. Of identifiable causes of POI, the most common are concurrent autoimmune diseases such as thyroid and adrenal disease, and chromoso...
Source: Current Obstetrics and Gynecology Reports - September 3, 2014 Category: OBGYN Source Type: research

1497p * lessons from the past: long-term safety and efficacy outcomes of a prematurely terminated, randomized phase iii trial of precautionary versus hemoglobin-based erythropoietin administration for chemotherapy-associated anemia in patients with solid tumors
Conclusions: Prophylactic administration of ESA for CIA in patients with solid tumors was associated with increased incidence of a composite of thrombosis-related adverse events, especially in patients receiving adjuvant treatment, but did not have a detrimental impact on relapse/progression and survival rates.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Mountzios, G., Aravantinos, G., Kouvatseas, G., Karina, M., Samantas, E., Papakostas, P., Skarlos, D., Galani, E., Kalofonos, H., Makatsoris, T., Bafaloukos, D., Pectasides, D. G., Fountzilas, G. Tags: supportive care Source Type: research

Green tea compound may improve cancer drugs
Conclusion This study developed a new way of packaging and carrying protein drugs by combining them with a green tea extract called Epigallocatechin-3-O-gallate (EGCG), which itself may have anti-cancer properties. They formed a complex between derivatives of EGCG and the protein cancer drug Herceptin. Tests in the laboratory and in mice indicated it might have better anti-cancer properties than non-complexed free Herceptin. This is encouraging research and may lead to improvements in delivery mechanisms for protein drugs further down the line. But this research remains at a very early stage of development. The results f...
Source: NHS News Feed - October 6, 2014 Category: Consumer Health News Tags: Cancer Medication Source Type: news

Factors Associated with Conversion from Laparoscopic to Open Colectomy using the National Surgical Quality Improvement Program (NSQIP) Database
ConclusionsMultiple significant factors for conversion from laparoscopic to open colectomy were identified. A novel finding was the increased risk of conversion for underweight patients. As laparoscopic colectomy is become increasingly utilized, factors predictive of conversion to open procedures should be sought via large, national cohorts.This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - October 14, 2014 Category: Gastroenterology Authors: Anuradha R. Bhama, Mary E. Charlton, Mary B. Schmitt, John W. Cromwell, John C. Byrn Tags: Original Article Source Type: research

Risk of thrombosis in women with malignancies undergoing ovarian stimulation for fertility preservation
CONCLUSIONS The available evidence on the risks of thrombosis for women undergoing ovarian stimulation for fertility preservation due to a malignancy is reassuring. However the avoidance of the early form of OHSS in women preserving oocytes/embryos due to malignancy is crucial. For these cycles, we advocate the use of a regimen of ovarian stimulation with gonadotrophin releasing hormone (GnRH) antagonists using GnRH agonists to trigger ovulation, an approach that has been shown to markedly reduce the risk of OHSS. Antithrombotic prophylaxis should be administered only to selected subgroups of women such as those with other...
Source: Human Reproduction Update - October 14, 2014 Category: OBGYN Authors: Somigliana, E., Peccatori, F. A., Filippi, F., Martinelli, F., Raspagliesi, F., Martinelli, I. Tags: Reviews Source Type: research

Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients – an observational study
Conclusions Bevacizumab acutely impairs microvascular function independent of blood pressure changes. Imaging of the retinal microcirculation seems a valuable tool for monitoring pharmacodynamic effects of bevacizumab. Trial registration NCT ID: NCT00740168
Source: Experimental and Translational Stroke Medicine - May 13, 2013 Category: Neurology Source Type: research

Managing Chemotherapy-Related Cardiotoxicity in Survivors of Childhood Cancers
Abstract In the US, children diagnosed with cancer are living longer, but not without consequences from the same drugs that cured their cancer. In these patients, cardiovascular disease is the leading cause of non-cancer-related morbidity and mortality. Although this review focuses on anthracycline-related cardiomyopathy in childhood cancer survivors, the global lifetime risk of other cardiovascular diseases such as atherosclerosis, arrhythmias and intracardiac conduction abnormalities, hypertension, and stroke also are increased. Besides anthracyclines, newer molecularly targeted agents, such as vascular endothe...
Source: Pediatric Drugs - October 1, 2014 Category: Pediatrics Source Type: research

Venous thromboembolism in children with acute lymphoblastic leukemia
Abstract Venous thromboembolism (VTE) occurs in 0.95–36 % of children with acute lymphoblastic leukemia almost exclusively during chemotherapy. It is most commonly associated with concurrent l-asparaginase and steroid therapy, central venous line use, and inherited thrombophilia. Clinical manifestations regarding the location of VTE include central nervous system thrombosis (sinus venous thrombosis, cerebral infarct/stroke), upper-/lower-limb deep venous thrombosis, pulmonary embolism, and right atrial/intracardiac and superficial venous thrombosis and can be both symptomatic and asymptomatic. The majority of ...
Source: Memo - Magazine of European Medical Oncology - September 1, 2014 Category: Cancer & Oncology Source Type: research

The mechanisms responsible for exercise intolerance in early-stage breast cancer: What role does chemotherapy play?
Publication date: June 2013 Source:Hong Kong Physiotherapy Journal, Volume 31, Issue 1 Author(s): Alis Bonsignore , Darren Warburton In this narrative review of the literature, we discuss the influence of chemotherapy treatment on peak aerobic power (VO2peak) for women with breast cancer and the mechanisms for exercise intolerance. In specific, we examine the central, peripheral, and oxygen transport mechanisms responsible for exercise intolerance in women living with breast cancer. Our findings indicate that reduced ventricular contractility, reduced left ventricular (LV) compliance, and increased afterload are (in part...
Source: Hong Kong Physiotherapy Journal - October 12, 2014 Category: Physiotherapy Source Type: research

The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure
Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are afflicted with a severe or life-threatening medical condition, with cardiovascular disease being a primary risk (96). Childhood cancer survivors have markedly elevated incidences of stroke, congestive heart failure (CHF), coronary artery disease, and valvular disease (96). Their cardiac mortality is 8.2 times higher tha...
Source: AJP: Heart and Circulatory Physiology - November 15, 2014 Category: Cardiology Authors: Lindsey, M. L., Lange, R. A., Parsons, H., Andrews, T., Aune, G. J. Tags: REVIEW Source Type: research

Increasing risks of ischemic stroke in oral cancer patients treated with radiotherapy or chemotherapy: a nationwide cohort study
International Journal of Neuroscience, Ahead of Print.
Source: International Journal of Neuroscience - October 22, 2014 Category: Neuroscience Tags: article Source Type: research

Hypertensive crisis: Reversible edema in leukoencephalopathy, retinopathy, now myelopathy?
The definition of the clinicoradiologic syndrome posterior reversible leukoencephalopathy syndrome (PRES) has been stretched over the last decade.1 Many regard PRES as a final common denominator for various cerebral insults, without a single etiopathogenic trigger.1,2 The hallmark of classic PRES is hydrostatic pressure breakthrough causing cerebral vasogenic edema, commonly coupled with a history of refractory hypertension, ictal surge in blood pressure (BP), and a concomitant systemic inflammatory or uremic process.1 High BP may be absent in PRES if there is renal failure; infection or any systemic inflammatory response ...
Source: Neurology - November 24, 2014 Category: Neurology Authors: Kapinos, G., Sanelli, P. C. Tags: Other cerebrovascular disease/ Stroke EDITORIALS Source Type: research