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Total 3361 results found since Jan 2013.

Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study Clinical Sciences
Conclusions— In this interim report, SB623 cells were safe and associated with improvement in clinical outcome end points at 12 months. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01287936.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Steinberg, G. K., Kondziolka, D., Wechsler, L. R., Lunsford, L. D., Coburn, M. L., Billigen, J. B., Kim, A. S., Johnson, J. N., Bates, D., King, B., Case, C., McGrogan, M., Yankee, E. W., Schwartz, N. E. Tags: Clinical Studies, Ischemia, Stem Cells, Transplantation, Treatment Clinical Sciences Source Type: research

Cerebral Organoids Repair Ischemic Stroke Brain Injury
AbstractStroke is the second leading cause of death and main cause of disability worldwide, but with few effective therapies. Although stem cell-based therapy has been proposed as an exciting regenerative medicine strategy for brain injury, there are limitations. The developed cerebral organoids (COs) represent a promising transplantation source for stroke that remains to be answered. Here, we transplanted COs at 55  days and explored the feasibility in the rat middle cerebral artery occlusion (MCAO) model of stroke. COs transplantation at 6 h or even 24 h after MCAO significantly reduces brain infarct volume and improv...
Source: Translational Stroke Research - December 29, 2019 Category: Neurology Source Type: research

Combining Growth Factor and Bone Marrow Cell Therapy Induces Bleeding and Alters Immune Response After Stroke in Mice Basic Sciences
Conclusions— Our results provide new insights into both BMC-based therapies and immune cell biology and help to understand potential adverse and unexpected side effects.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Strecker, J.-K., Olk, J., Hoppen, M., Gess, B., Diederich, K., Schmidt, A., Schabitz, W.-R., Schilling, M., Minnerup, J. Tags: Animal Models of Human Disease, Basic Science Research, Growth Factors/Cytokines, Inflammation, Treatment Basic Sciences Source Type: research

Integrin {alpha}4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Inȷection Brief Report
Conclusions—ITGA4 overexpression on MSCs enhances transendothelial migration in vitro, but not in vivo, although it improves safety after intracarotid transplantation into stroke rats.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Li–li Cui, Franziska Nitzsche, Evgeny Pryazhnikov, Marina Tibeykina, Laura Tolppanen, Jussi Rytkonen, Tuulia Huhtala, Jing–wei Mu, Leonard Khiroug, Johannes Boltze, Jukka Jolkkonen Tags: Cell Therapy, Translational Studies, Ischemic Stroke Brief Reports Source Type: research

Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial
AbstractMesenchymal stromal cells (MSCs) can differentiate into multiple tissues. Preclinical studies have shown that MSC-based therapy is a potential new treatment approach for ischemic stroke. These results support the urgent need for further studies of MSC transplantation in the treatment of ischemic stroke in humans. Here, we develop a prospective, randomized, controlled, observer-blinded phase II trial to assess the clinical safety, feasibility, and therapeutic mechanisms of allogenic bone marrow-derived MSCs (BM-MSCs) by intrathecal infusion in the treatment of patients with cerebral infarction within the middle cere...
Source: Translational Stroke Research - May 23, 2018 Category: Neurology Source Type: research

Transplantation of Directly Reprogrammed Human Neural Precursor Cells Following Stroke Promotes Synaptogenesis and Functional Recovery
AbstractStroke is one of the leading causes of long-term disability. Cell transplantation is a promising strategy to treat stroke. We explored the efficacy of directly reprogrammed human neural precursor cell (drNPC) transplants to promote functional recovery in a model of focal ischemic stroke in the mouse sensorimotor cortex. We show that drNPCs express neural precursor cell markers and are neurally committed at the time of transplantation. Mice that received drNPC transplants recovered motor function, irrespective of transplant vehicle or recipient sex, and with no correlation to lesion volume or glial scarring. The maj...
Source: Translational Stroke Research - February 12, 2019 Category: Neurology Source Type: research

Transplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke
AbstractClinical evidence affirms physical exercise is effective in preventive and rehabilitation approaches for ischemic stroke. This sustainable efficacy is independent of cardiovascular risk factors and associates substantial reprogramming in circulating extracellular vesicles (EVs). The intricate journey of pluripotent exercise-induced EVs from parental cells to the whole-body and infiltration to cerebrovascular entity offers several mechanisms to reduce stroke incidence and injury or accelerate the subsequent recovery. This review delineates the potential roles of EVs as prospective effectors of exercise. The candidat...
Source: Translational Stroke Research - May 21, 2022 Category: Neurology Source Type: research

Cell-based treatment for stroke moves a step closer
Brain infarction or stroke is caused by a blood clot blocking a blood vessel in the brain, which leads to interruption of blood flow and shortage of oxygen. Now a reserach group at Lund University, Sweden, has taken an important step towards a treatment for stroke using stem cells. The research group shows in a new study, published in the scientific journal Brain, that so-called induced pluripotent stem cells have developed to mature nerve cells at two months after transplantation into the stroke-injured cerebral cortex of rats...
Source: Health News from Medical News Today - October 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

The effect of fecal microbiota transplantation on stroke outcomes: A systematic review
Fecal microbiota transplantation (FMT) is a novel microbiota-based therapeutic method that transfers stool from donor into a recipient and its application is under investigating for neurological disorders such as stroke. In this systematic review, we assessed the effect of FMT in progression and treatment of stroke and recovery of post-stroke complications.
Source: Journal of Stroke and Cerebrovascular Diseases - September 23, 2022 Category: Neurology Authors: Amir Pasokh, Mohammad Farzipour, Javad Mahmoudi, Saeed Sadigh-Eteghad Source Type: research

Platelet Lysate and Granulocyte-Colony Stimulating Factor Serve Safe and Accelerated Expansion of Human Bone Marrow Stromal Cells for Stroke Therapy
This study was aimed to assess whether the hBMSCs enhance their proliferation capacity and provide beneficial effect in the infarct brain when cultured with platelet lysate (PL) and granulocyte-colony stimulating factor (G-CSF). The hBMSCs were cultured in the fetal calf serum (FCS)-, PL-, or PL/G-CSF-containing medium. Cell growth kinetics was analyzed. The hBMSCs-PL, hBMSC-PL/G-CSF, or vehicle was stereotactically transplanted into the ipsilateral striatum of the rats subjected to permanent middle cerebral artery occlusion 7 days after the insult. Motor function was assessed for 8 weeks, and the fate of transplanted hB...
Source: Translational Stroke Research - October 30, 2014 Category: Neurology Source Type: research

Acute ischemic stroke due to Left Ventricular Noncompaction Syndrome from a novel mutation of the Lamin A/C gene (P2.254)
Conclusion: LVNC is a risk factor for cardioembolic ischemic stroke particularly in young patients that is not well known. Patients with suspected LVNC by echocardiography should undergo cardiac MRI for confirmation and genetic testing in particular for mutations in the LMNA gene. The prognosis of those with LVNC syndrome is poor; most worsen over time and need ultimately transplantation. Close follow-up is required.Disclosure: Dr. Vongveeranonchai has nothing to disclose. Dr. Mittal has nothing to disclose. Dr. Ramos Estebanez has nothing to disclose. Dr. DeGeorgia has received personal compensation for activities with OS...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Vongveeranonchai, N., Mittal, S., Ramos Estebanez, C., De Georgia, M. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Cerebral Microbleeds Predict Intracerebral Hemorrhage in Hemodialysis Patients Clinical Sciences
Conclusions— This study showed that the presence of CMBs was an independent and strong predictor of intracerebral hemorrhage in stroke-free hemodialysis patients, indicating that hemodialysis patients with CMBs should be carefully monitored for future onset of intracerebral hemorrhage.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Naganuma, T., Takemoto, Y., Shoji, T., Ishimura, E., Okamura, M., Nakatani, T. Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging, Intracerebral Hemorrhage, Risk Factors for Stroke Clinical Sciences Source Type: research

Cell Therapy in Stroke —Cautious Steps Towards a Clinical Treatment
AbstractIn the future, stroke patients may receive stem cell therapy as this has the potential to restore lost functions. However, the development of clinically deliverable therapy has been slower and more challenging than expected. Despite recommendations by STAIR and STEPS consortiums, there remain flaws in experimental studies such as lack of animals with comorbidities, inconsistent approaches to experimental design, and concurrent rehabilitation that might lead to a bias towards positive results. Clinical studies have typically been small, lacking control groups as well as often without clear biological hypotheses to g...
Source: Translational Stroke Research - November 17, 2017 Category: Neurology Source Type: research

Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain
AbstractChronic brain injury following cerebral ischemia is a severe debilitating neurological condition, where clinical intervention is well known to decrease morbidity and mortality. Despite the development of several therapeutic strategies, clinical outcome in the majority of patients could be better improved, since many still face life-long neurological deficits. Among the several strategic options that are currently being pursued, tissue engineering provides much promise for neural tissue salvage and regeneration in brain ischemia. Specifically, hydrogel biomaterials have been utilized to docket biomolecules, adhesion...
Source: Translational Stroke Research - August 27, 2018 Category: Neurology Source Type: research

Bone Marrow Mononuclear Cells Transplantation and Training Increased Transplantation of Energy Source Transporters in Chronic Stroke
Bone marrow mononuclear cells (BM-MNC) show a significant therapeutic effect in combination with training even in the chronic phase of stroke. However, the mechanism of this combination therapy has not been investigated. Here, we examined its effects on brain metabolism in chronic stroke mice.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Yuko Ogawa, Orie Saino, Yuka Okinaka, Akie Kikuchi-Taura, Yukiko Takeuchi, Akihiko Taguchi Source Type: research