Integrin {alpha}4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Inȷection [Brief Report]

Conclusions—ITGA4 overexpression on MSCs enhances transendothelial migration in vitro, but not in vivo, although it improves safety after intracarotid transplantation into stroke rats.

Source: Stroke - September 25, 2017 Category: Neurology Authors: Li–li Cui, Franziska Nitzsche, Evgeny Pryazhnikov, Marina Tibeykina, Laura Tolppanen, Jussi Rytkonen, Tuulia Huhtala, Jing–wei Mu, Leonard Khiroug, Johannes Boltze, Jukka Jolkkonen Tags: Cell Therapy, Translational Studies, Ischemic Stroke Brief Reports Source Type: research