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Condition: Pregnancy
Procedure: Perfusion

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Total 28 results found since Jan 2013.

Stroke in Pregnancy and Review of Current Literature: Arterial Spin-Labeling MRI Can Identify the Presence and Intensity of Collateral Circle
We present a diagnostic strategy in a pregnant woman with suspect of acute stroke. We perform magnetic resonance with arterial spin labeling sequence, an X-ray and contrast medium safe perfusion technique. Arterial spin labeling can detects collateral vessels in patient with acute ischemic stroke. Demonstrating collateral vessels is relevant for better understanding prognosis and for improving the diagnostic assessment in pregnancy.
Source: Journal of Stroke and Cerebrovascular Diseases - September 15, 2018 Category: Neurology Authors: Agnese Morello, Tommaso Casseri, Maurizio Acampa, Paolo Galluzzi, Alfonso Cerase, Lucia Monti Source Type: research

Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in Pregnant Stroke-Prone Spontaneously Hypertensive RatsNovelty and Significance Preeclampsia
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine ...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Hannah L. Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W. McBride, Delyth Graham Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease, Hypertension, Preeclampsia Original Articles Source Type: research

Acute Ischemic Stroke in Pregnancy
ConclusionFetal safety concerns should not preclude routine diagnostic work-up (except for gadolinium contrast media administration) in childbearing AIS women, including procedures applied in unknown onset and late onset individuals. Due to rather low added risk of serious treatment complications, pregnancy should not be a  sole contraindication for neither IVT, nor endovascular treatment.
Source: Clinical Neuroradiology - September 16, 2022 Category: Neurology Source Type: research

A Serious Diagnosis Lacking Common Symptoms
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; & AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regi...
Source: The Case Files - May 28, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infarcts...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep.
This article is protected by copyright. All rights reserved. PMID: 26077461 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 16, 2015 Category: Physiology Authors: Galinsky R, Davidson JO, Drury PP, Wassink G, Lear CA, van den Heuij LG, Gunn AJ, Bennet L Tags: J Physiol Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Hypertensive Emergencies of Pregnancy
Hypertension is commonly encountered in pregnancy and has both maternal and fetal effects. Acute hypertensive crisis most commonly occurs in severe preeclampsia and is associated with maternal stroke, cardiopulmonary decompensation, fetal decompensation due to decreased uterine perfusion, abruption, and stillbirth. Immediate stabilization of the mother including the use of intervenous antihypertensives is required and often delivery is indicated. With appropriate management, maternal and fetal outcomes can be excellent.
Source: Obstetrics and Gynecology Clinics - March 1, 2013 Category: OBGYN Authors: James M. Alexander, Karen L. Wilson Source Type: research

Hemodynamic adaptation to pregnancy in women with structural heart disease
Conclusions: The characteristic pattern of hemodynamic adaptation to pregnancy is attenuated in women with structural heart disease. The pregnancy related volume load induces progression of diastolic dysfunction. Our data suggest a persistent reduction in systolic and diastolic cardiac functions after pregnancy in women with structural heart disease.
Source: International Journal of Cardiology - November 13, 2012 Category: Cardiology Authors: J. Cornette, T.P.E. Ruys, A. Rossi, D. Rizopoulos, J.J.M. Takkenberg, Y. Karamermer, P. Opić, A.E. Van den Bosch, M.L. Geleijnse, J.J. Duvekot, E.A.P. Steegers, J.W. Roos-Hesselink Tags: Original Articles Source Type: research

Blood–Brain Barrier Breakdown in Reduced Uterine Perfusion Pressure: A Possible Model of Posterior Reversible Encephalopathy Syndrome
Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical entity characterized by headaches, altered mental status, seizures, and visual disturbances and is associated with white matter vasogenic edema. There are no experimental models to study PRES brain changes.Methods: Twenty-eight pregnant Wistar rats were divided into 4 groups of 7: (1) pregnant-control; (2) reduced uterine perfusion pressure (RUPP); (3) invasive blood pressure (IBP); and (4) reduced uterine perfusion pressure plus invasive blood pressure (RUPP-IBP). The RUPP and RUPP-IBP groups were submitted to a reduction of uterine perfusion pr...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Luiz Carlos Porcello Marrone, Giovani Gadonski, Gabriela de Oliveira Laguna, Carlos Eduardo Poli-de-Figueiredo, Bartira Ercilia Pinheiro da Costa, Maria Francisca Torres Lopes, João Pedro Farina Brunelli, Luciano Passamani Diogo, Antônio Carlos Huf Marr Tags: Original Articles Source Type: research

Platelet aggregation inhibition by Eptifibatide versus high dose Tirofiban during primary percutaneous interventions
Conclusions • Platelet aggregation inhibition during PCI was significantly correlated with STR and MBG. Platelet aggregation inhibition cut-off point as a predictor of STR >70% was 89.5%, and as a predictor of MBG 2–3 was 87.5%. • Eptifibatide achieves better platelet aggregation inhibition 60min after bolus and 6h after PCI than high dose Tirofiban. • Eptifibatide is associated with better myocardial perfusion as indicated by post procedural mean MBG and STR >70% than high dose Tirofiban. • There was no significant differences between Eptifibatide and high dose Tirofiban regarding thrombocytope...
Source: The Egyptian Heart Journal - November 6, 2014 Category: Cardiology Source Type: research

Upper extremity arterial thrombus presenting at birth
We report a 36-week neonate born to a 31-year-old G2P0 woman by emergency c-section due to decreased fetal movement. The pregnancy had been uncomplicated up to that point and the mother had no significant medical history. Birth weight was 2.49 kg. Apgars were 6 and 5. Superficial skin loss and dark blue discolouration were noted along the left upper extremity and hand immediately after delivery. Fluid resuscitation and sterile saline wraps slowly improved perfusion, and the extremity pinked up over the subsequent 3 h (figure 1). She was transferred to an appropriate outside facility where Doppler ultrasound revea...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 16, 2016 Category: Perinatology & Neonatology Authors: LaBore, B. P., Bedell, T. H. Tags: Journalology, Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Competing interests (ethics), Resuscitation, Trauma Images in neonatal medicine Source Type: research

Preeclampsia and health risks later in life: an immunological link
Abstract Pregnancy represents a period of physiological stress, and although this stress is experienced for a very modest portion of life, it is now recognized as a window to women’s future health, often by unmasking predispositions to conditions that only become symptomatic later in life. In normal pregnancy, the mother experiences mild metabolic syndrome-like condition through week 20 of gestation. A pronounced phenotype of metabolic syndrome may program pregnancy complications such as preeclampsia. Preeclampsia is a serious complication with a myriad of manifestations for mother and offspring. This pregnancy ...
Source: Seminars in Immunopathology - June 22, 2016 Category: Pathology Source Type: research

Characterisation of early pregnancy dependent gene expression changes in the uterine artery of hypertensive and normotensive rats
This study investigated the causative effects of early pregnancy on the uterine artery transcriptome profile in SHRSP and normotensive Wistar Kyoto (WKY) rats.
Source: Placenta - August 30, 2017 Category: Reproduction Medicine Authors: Hannah Morgan, Elisabeth Beattie, Martin McBride, Delyth Graham Source Type: research