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Economic evaluation of the Very Early Rehabilitation in SpEech (VERSE) intervention
CONCLUSION: There was limited evidence that additional intensively delivered aphasia therapy within the context of usual acute care provided was worthwhile in terms of costs for the outcomes gained.PMID:37415422 | DOI:10.1080/10749357.2023.2229039
Source: Topics in Stroke Rehabilitation - July 7, 2023 Category: Neurology Authors: J Kim G Sookram E Godecke E Brogan E Armstrong F Ellery T Rai M L Rose N Ciccone S Middleton A Holland G J Hankey J Bernhardt D A Cadilhac Source Type: research

Exploring facilitators and barriers to long ‐term behavior change following health–wellness coaching for stroke prevention: A qualitative study conducted in Auckland, New Zealand
ConclusionsEnhancing awareness of personal risk and the impact of potential disease are facilitators of long-term behavior change and should be incorporated into coaching conversations. This supports the process of “waking up” to health needs and the possibility of change, which are important precursors to long-term change. Health coaching should be responsive to individual need, with emotional well-being, happiness, and life satisfaction being addressed alongside physical health. The opportunity to develo p skills to support decision-making and self-management should be included in coaching initiatives, to enhance sel...
Source: Brain and Behavior - December 13, 2022 Category: Neurology Authors: Caroline Holder, Rita Krishnamurthi, Alice Theadom Tags: ORIGINAL ARTICLE Source Type: research

Higher BMI Confers a Long-Term Functional Status Advantage in Elderly New Zealand European Stroke Patients
Obesity is a risk factor for ischaemic stroke but provides a survival advantage. The relationship between body mass index (BMI) and long-term function is less clear. The presence of an obesity paradox can inform clinical care and identify vulnerable patients who need additional support post-stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Shivankar Nair, Siyi Chen, Deepak Gupta, Alesha J. Smith, Ailsa L. McGregor Source Type: research

Tocilizumab Reduces Vasospasms, Neuronal Cell Death, and Microclot Formation in a Rabbit Model of Subarachnoid Hemorrhage
AbstractEarly brain injury (EBI), delayed cerebral vasospasm (DCVS), and delayed cerebral ischemia (DCI) are common complications of subarachnoid hemorrhage (SAH). Inflammatory processes in the cerebrospinal fluid (CSF) are one of the causes for such complications. Our aim to study the effects of an IL-6 receptor antagonist (Tocilizumab) examines the occurrence of DCVS, neuronal cell death, and microclot formation in an acute SAH rabbit model. Twenty-nine New Zealand white rabbits were randomized into one of three groups as the SAH, SAH + Tocilizumab, and sham groups. In SAH groups, hemorrhage was induced by extracranial-i...
Source: Translational Stroke Research - January 6, 2021 Category: Neurology Source Type: research

Fluoxetine for stroke recovery improvement - the doubleblind, randomised placebo-controlled FOCUS-Poland trial.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Consistent with other trials based on the FOCUS protocol, fluoxetine did not improve motor recovery or general stroke outcome at six and 12 months in the Polish cohort studied. However, patients receiving fluoxetine required therapy with additional antidepressant medication less frequently. PMID: 33373036 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - December 29, 2020 Category: Neurology Authors: Bembenek JP, Niewada M, Kłysz B, Mazur A, Kurczych K, Głuszkiewicz M, Członkowska A Tags: Neurol Neurochir Pol Source Type: research

Opposing Associations of Stress and Resilience With Functional Outcomes in Stroke Survivors in the Chronic Phase of Stroke: A Cross-Sectional Study
Stroke survivors report significant levels of psychological distress post stroke. To date, most studies conducted have focused on the relationship between psychological stress and functional outcomes in the acute phase of stroke. However, no studies had considered the role of stress over the chronic phase, where stress may continue to exert negative effects on cognitive and psychological processes. Further, the role of potentially modulatory variables, such as psychological resilience, on stroke outcomes has been understudied. The purpose of this study was to consider the relationships between stress and resilience with fu...
Source: Frontiers in Neurology - April 21, 2020 Category: Neurology Source Type: research

Inducing ketogenesis via an enteral formulation in patients with acute brain injury:a phase II study.
Conclusion: In patients with acute brain injury, an enterally administered ketogenic formulation increased plasma ketone concentrations, was well tolerated, did not impact on cerebral hemodynamics and can be safely administered.Clinical trial registered at the Australian New Zealand Clinical Trials Registry (ACTRN12616000332426)Abbreviations: BHB: betahydroxybutyrate; AcAc: acetoacetate; ABI: acute brain injury; TBI: traumatic brain injury; CSF: cerebrospinal fluid; SAH: subarachnoid injury; CVA: cerebrovascular accidents; ICP: intracranial pressure; CPP: cerebral perfusion pressure; ICU: intensive care unit; EVD: external...
Source: Neurological Research - February 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Community Knowledge and Awareness of Stroke in New Zealand
Introduction: Community knowledge and stroke awareness is crucial for primary prevention of stroke and timely access to stroke treatments including acute reperfusion therapies. We conducted a national telephone survey to quantify the level of community stroke awareness. Methods: A random sample of 400 adults in New Zealand (NZ), stratified by the 4 main ethnic groups, was surveyed. Eligible participants answered stroke awareness questions using both unprompted (open-ended) and prompted questions (using a list).
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2019 Category: Neurology Authors: Rita V. Krishnamurthi, Suzanne Barker-Collo, Peter Alan Barber, Lynette J. Tippett, John C. Dalrymple-Alford, Bronwyn Tunnage, Susan Mahon, Priyakumari G. Parmar, Melanie Moylan, Valery L. Feigin Source Type: research

Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.
Conclusions: We provide evidence that fALFF is sensitive to changes in poststroke depressive symptom severity and implicates frontostriatal and cerebellar regions, consistent with previous studies. The use of multiband analysis could be an effective method to examine neural correlates of depression after stroke. The START-PrePARE trial is registered with the Australian New Zealand Clinical Trial Registry, number ACTRN12610000987066. PMID: 31467520 [PubMed - in process]
Source: Neural Plasticity - August 31, 2019 Category: Neurology Authors: Goodin P, Lamp G, Vidyasagar R, Connelly A, Rose S, Campbell BCV, Tse T, Ma H, Howells D, Hankey GJ, Davis S, Donnan G, Carey LM Tags: Neural Plast Source Type: research

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