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Nutrition: Vitamin B12

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Total 86 results found since Jan 2013.

Prevalence of Vitamin B12 Deficiency in a Rehabilitation Hospital
To evaluate the prevalence of vitamin B12 deficiency in a rehabilitation hospital in the following subgroups: spinal cord injury, stroke, brain injury, and patients with Parkinson ’s disease. Moreover, the analysis will be carried out according to the patients’ gender and age.
Source: Archives of Physical Medicine and Rehabilitation - November 23, 2016 Category: Rehabilitation Authors: Debora Precioso Tags: Research poster Source Type: research

B vitamins and cognition in subjects with small vessel disease: A Substudy of VITATOPS, a randomized, placebo-controlled trial
VITAmins TO Prevent Stroke (VITATOPS) study, a randomized, double-blind international multi-centre trial involving 8164 subjects in studying effect of lowering homocysteine level by daily administration of B-vitamins (2mg folic acid, 25mg vitamin B6, and 0.5mg vitamin B12) failed to demonstrate a positive effect of B-vitamins in reducing incidence of major vascular events and global cognition decline as measured by mini-mental state examination (MMSE) score [1,2]. However, assessment of cognition using MMSE alone has its limitations and a full neuropsychological assessment of different cognitive domains will provide more robust evidence.
Source: Journal of the Neurological Sciences - May 30, 2017 Category: Neurology Authors: Simon Kang Seng Ting, Arul Earnest, Huihua Li, Shahul Hameed, Hui Meng Chang, Christopher Li Hsian Chen, Eng-King Tan Tags: Letter to the Editor Source Type: research

The relation between vitamin B12 and SYNTAX score.
CONCLUSIONS: In our study, we found a significant relationship between vitamin B12 deficiency and SYNTAX score, demon-strating the severity and complexity of coronary artery disease. PMID: 27391912 [PubMed - indexed for MEDLINE]
Source: Kardiologia Polska - July 15, 2017 Category: Cardiology Authors: Cerit L, Duygu H, Gulsen K, Kemal H, Tosun O, Ozcem B, Cerit Z, Gunsel A Tags: Kardiol Pol Source Type: research

Vitamin B12 Deficiency: Recognition and Management.
Abstract Vitamin B12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. Screening average-risk adults for vitamin B12 deficiency is not recommended. Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years. Initial laboratory assessment should include a complete blood count ...
Source: American Family Physician - September 15, 2017 Category: Primary Care Authors: Langan RC, Goodbred AJ Tags: Am Fam Physician Source Type: research

Hyperhomocysteinemia as a Risk Factor for Saccular Intracranial Aneurysm: A Cohort Study in a Chinese Han Population
We evaluated the possible relationships between serum total homocysteine and folate and Vitamin B12 in patients with intracranial aneurysm.
Source: Journal of Stroke and Cerebrovascular Diseases - September 21, 2017 Category: Neurology Authors: Jin-Rui Ren, Shao-Hua Ren, Bo Ning, Jun Wu, Yong Cao, Xin-Min Ding, Zi-Gang Zhen, Xu-Dong Hao, Shuo Wang Source Type: research

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

Vitamin B12.
Abstract The biosynthesis of B12, involving up to 30 different enzyme-mediated steps, only occurs in bacteria. Thus, most eukaryotes require an external source of B12, and yet the vitamin appears to have only two functions in eukaryotes: as a cofactor for the enzymes methionine synthase and methylmalonylCoA mutase. These two functions are crucial for normal health in humans, and in particular, the formation of methionine is essential for providing methyl groups for over 100 methylation processes. Interference with the methionine synthase reaction not only depletes the body of methyl groups but also leads to the ac...
Source: Advances in Food and Nutrition Research - February 27, 2018 Category: Nutrition Authors: Smith AD, Warren MJ, Refsum H Tags: Adv Food Nutr Res Source Type: research

A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation. Background Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Implication of Homocysteine in protein quality control processes.
Abstract Homocysteine (Hcy) is a key metabolite generated during methionine metabolism. The elevated levels of Hcy in the blood is reffered as hyperhomocystenimeia (HHcy). The HHcy is caused by imapired metabolism/deficiency of either folate, or B12 or defects in Hcy metabolism. Accumulating evidence suggests that HHcy is associated with cardiovascular and brain diseases including atherosclerosis, endothelial injury, and stroke etc. Vitamin B12 (cobalamin; B12) is a water-soluble vitamin essential for two metabolic reactions. It acts as a co-factor for methionine synthase and L-methylmalonyl-CoA mutase. Besides, i...
Source: Biochimie - June 29, 2019 Category: Biochemistry Authors: Reddy VS, Trinath J, Reddy GB Tags: Biochimie Source Type: research

Partially reversible acute renal cortical necrosis secondary to hyperhomocysteinemia & #8211; A case report and literature review
In conclusion, this is a rare case of ACN, which may have occurred as a complication of hyperhomocysteinemia.
Source: Indian Journal of Nephrology - July 15, 2019 Category: Urology & Nephrology Authors: Wendy Tan Fauzah Abd Ghani Christopher Thiam Seong Lim Source Type: research

Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience From a Tertiary Care Hospital in North India*
Conclusions: We observed a high prevalence of critical illness polyneuropathy in children in PICU, mechanically ventilated for 7 days or more; almost all of whom had underlying sepsis.
Source: Pediatric Critical Care Medicine - September 1, 2019 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Effect of Vitamin B12 Levels on the Association Between Folic Acid Treatment and CKD Progression: A Post Hoc Analysis of a Folic Acid Interventional Trial
ConclusionsFolic acid treatment was associated with a greater reduction in the odds of CKD progression among patients with mild to moderate CKD and higher B12 levels.FundingGovernment funding (National Key Research and Development Program of China).
Source: American Journal of Kidney Diseases - October 17, 2019 Category: Urology & Nephrology Source Type: research

Neurology: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Absent Superficial Abdominal Reflex due to thoracic spinal cord neuromyelitis. NEJM, 05/2014.Kayser-Fleischer Rings in Wilson ' s Disease. NEJM, 03/2012.Perilymph Fistula Test leads to nystagmus. NEJM, 01/2012.A stray bullet in the brain - with no deficit of power, cognition, sense of touch, or speech. Lancet, 01/2012.Blindness after Fat Injections. NEJM, 12/2011.Internal-Carotid-Artery Dissection and Cranial-Nerve Palsies. NEJM, 12/2011.A Head Shot. NEJM, 12/2011.Multiple Intracranial Tuberculomas. NEJM, 10/2011....
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Neurology Source Type: news

Association of vitamin B12 transporter protein (transcobalamin II) genetic polymorphisms with risk of stroke: An observational pilot study in north Indian population
Publication date: Available online 16 June 2020Source: Meta GeneAuthor(s): Parmila Dudi, Anita Rani, Bela Goyal, Geeta Kampani, Kamlesh Rabari, Ashish Kothari, Sarama Saha
Source: Meta Gene - June 17, 2020 Category: Genetics & Stem Cells Source Type: research

Neurology: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Absent Superficial Abdominal Reflex due to thoracic spinal cord neuromyelitis. NEJM, 05/2014.Kayser-Fleischer Rings in Wilson ' s Disease. NEJM, 03/2012.Perilymph Fistula Test leads to nystagmus. NEJM, 01/2012.A stray bullet in the brain - with no deficit of power, cognition, sense of touch, or speech. Lancet, 01/2012.Blindness after Fat Injections. NEJM, 12/2011.Internal-Carotid-Artery Dissection and Cranial-Nerve Palsies. NEJM, 12/2011.A Head Shot. NEJM, 12/2011.Multiple Intracranial Tuberculomas. NEJM, 10/2011....
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Neurology Source Type: news