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Total 3873 results found since Jan 2013.
Home-based portable fNIRS-derived cortical laterality correlates with impairment and function in chronic stroke
DiscussionThese results indicate it is feasible to gain M1-LAT measures from stroke survivors in their homes using fNIRS. These findings represent a preliminary step toward the goals of using ergonomic functional neuroimaging to improve post-stroke rehabilitative care, via the capture of neural biomarkers of post-stroke motor recovery, and/or via use as part of an accessible rehabilitation brain-computer-interface.
Source: Frontiers in Human Neuroscience - December 9, 2022 Category: Neuroscience Source Type: research
Early stimulation treatment provides complete sensory‐induced protection from ischemic stroke under isoflurane anesthesia
This study demonstrated that the isoflurane‐anesthetised rat pMCAO model can be used for cerebrovascular studies, and allows for highly detailed investigation of potential novel treatments for ischemic stroke using awake, behaving animals.
Using a rat model of ischemia (permanent middle cerebral artery occlusion; pMCAO) we demonstrate that whisker stimulation can completely protect the cortex from impending stroke. Furthermore, the broad extent of evoked activity evident under isoflurane anesthesia plays a significant role in the protection from, or deterioration towards infarct. We conclude that the pMCAO model may be ...
Source: European Journal of Neuroscience - April 16, 2013 Category: Neuroscience Authors: Christopher C. Lay, Nathan Jacobs, Aneeka M. Hancock, Yi Zhou, Ron D. Frostig Tags: Research Report Source Type: research
A Framework of Counseling for Patients With Stroke in Nursing: A Narrative Literature Review
ABSTRACTStroke is a major cause of death in developed countries. Its prevalence and disability burden are expected to increase in the future because of an aging population. The consequences of stroke are specific to the individual. Whereas some patients experience long-term functional and cognitive deficits, others may recover completely and be discharged quickly. Counseling is needed to help patients and their families cope with the effects of stroke after discharge. This is a systematic literature review with a narrative analysis. The purpose was to describe the content and characteristics of stroke patients’ counselin...
Source: Journal of Neuroscience Nursing - October 1, 2014 Category: Neuroscience Tags: Article Source Type: research
Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats
We describe a positive influence of pre-stroke surgery on recovery and survival in a commonly used experimental stroke model. Two groups of male, stroke-prone spontaneously hypertensive rats (SHRSPs) underwent transient middle cerebral artery occlusion (tMCAO). Group 1 underwent the procedure without any prior intervention whilst group 2 had an additional general anaesthetic 6 days prior to tMCAO for a cranial burrhole and durotomy. Post-stroke recovery was assessed using a 32 point neurological deficit score and tapered beam walk and infarct volume determined from haematoxylin–eosin stained sections. In group 2 survival...
Source: Journal of Neuroscience Methods - November 8, 2014 Category: Neuroscience Source Type: research
Patient Perspectives of Barriers and Facilitators of Treatment-Seeking Behaviors for Stroke Care
Conclusions: Individuals who experience strokes face a number of facilitators and barriers to seeking urgent care for their condition. Facilitators and barriers are associated with stroke symptoms and their personal environments. Additional study of barriers to stroke care is needed to adequately design interventions to reduce delays in seeking treatment.
Source: Journal of Neuroscience Nursing - May 8, 2015 Category: Neuroscience Tags: Article Source Type: research
Sex differences in the immune response to experimental stroke: Implications for translational research
Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than males and, therefore, have a worse stroke outcome. There are also major differences in how the sexes respond to stroke at the cellular level. Immune response is a critical factor in determining the progress of neurodegeneration after stroke and is fundamentally different for males and females. Additionally, fema...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Abby L. Dotson, Halina Offner Tags: Mini ‐Review Source Type: research
Association of GWAS-Reported Variant rs11196288 near HABP2 with Ischemic Stroke in Chinese Han Population
AbstractA recent genome-wide association analysis identified a novel single nucleotide polymorphism locus on chromosome 10q25.3 (rs11196288, nearHABP2) associated with the risk of early-onset ischemic stroke (IS) in European population, but not with late-onset IS. However, the role of this genome-wide association study (GWAS)-reported variant in ischemic stroke in Chinese Han population remained unknown. In our study, 389 adult ischemic stroke patients with an age of onset<60 years and 389 matched healthy controls were enrolled to investigate association of rs11196288 genotypes with early-onset ischemic stroke and its...
Source: Journal of Molecular Neuroscience - May 13, 2017 Category: Neuroscience Source Type: research
Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis
AbstractSeveral brain imaging markers have been studied in the development of post-stroke depression (PSD) and post-stroke apathy (PSA), but inconsistent associations have been reported. This systematic review and meta-analysis aims to provide a comprehensive and up-to-date evaluation of imaging markers associated with PSD and PSA. Databases (Medline, Embase, PsycINFO, CINAHL, and Cochrane Database of Systematic Reviews) were searched from inception to July 21, 2016. Observational studies describing imaging markers of PSD and PSA were included. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to ex...
Source: Neuropsychology Review - August 22, 2017 Category: Neuroscience Source Type: research
Changes in structure and perfusion of grey matter tissues during recovery from Ischaemic subcortical stroke: a longitudinal MRI study
This study provides the imaging evidence of structural and vascular plasticity after stroke and expands our understanding of neurobiology of stroke recovery.
Source: European Journal of Neuroscience - September 4, 2017 Category: Neuroscience Authors: Xinfeng Yu, Linglin Yang, Ruirui Song, Yerfan Jiaerken, Jun Yang, Min Lou, Quan Jiang, Minming Zhang Tags: Research Report Source Type: research
Sleep-Wake Disorders in Stroke —Increased Stroke Risk and Deteriorated Recovery? An Evaluation on the Necessity for Prevention and Treatment
AbstractPurpose of ReviewSleep-wake disorders (SWD) are common not only in the general population but also in stroke patients, in whom SWD may be pre-existent or appear “de novo” as a consequence of brain damage. Despite increasing evidence of a negative impact of SWD on cardiocerebrovascular risk, cognitive functions, and quality of life, SWD are insufficiently considered in the prevention and management of patients with stroke. This narrative review aims at s ummarizing the current data on the bidirectional link between SWD and stroke.Recent FindingsSeveral studies have demonstrated that sleep-disordered breathing (S...
Source: Current Neurology and Neuroscience Reports - September 7, 2018 Category: Neuroscience Source Type: research
The effect of age, sex and strains on the performance and outcome in animal models of stroke
Publication date: Available online 3 October 2018Source: Neurochemistry InternationalAuthor(s): Hongxia Zhang, Siyang Lin, Xudong Chen, Lei Gu, Xiaohong Zhu, Yinuo Zhang, Kassandra Reyes, Brain Wang, Kunlin JinAbstractStroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcome...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research
HDAC9 Polymorphisms Predict Susceptibility, Severity, and Short-Term Outcome of Large Artery Atherosclerotic Stroke in Chinese Population
This study aimed to investigate whether these two polymorphisms were associated with susceptibility, severity, and short-term outcome of LAA stroke in a southern Chinese Han population. rs2074633 and rs28688791 were genotyped using SNPscan technology in 1011 LAA stroke patients and 1121 healthy controls. Stroke severity on admission and short-term outcome were, respectively, assessed by the National Institute of Health Stroke Scale (NIHSS) score on admission and modified Rankin Scale score at 3 months after stroke onset. rs2074633 (P = 0.039) and rs28688791 (P = 0.025) were associated with risk of LAA stroke. In ...
Source: Journal of Molecular Neuroscience - December 18, 2018 Category: Neuroscience Source Type: research
A troponin study on patients with ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage: Type II myocardial infarction is significantly associated with stroke severity, discharge disposition and mortality
Publication date: Available online 20 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ayham M. Alkhachroum, Benjamin Miller, Tarek Chami, Curtis Tatsuoka, Cathy SilaAbstractTroponin elevations due to Type II myocardial infarction (T2MI) are associated with hemorrhagic and ischemic strokes but there is little data on stroke severity, troponin elevation and outcome. We studied 1655 patients from a tertiary medical center between 1/2013-4/2015 using multivariate regression analysis for demographics, vascular risk factors, admission stroke severity, laboratory tests, echocardiogram results and discharge dispositio...
Source: Journal of Clinical Neuroscience - April 21, 2019 Category: Neuroscience Source Type: research
Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis
AbstractIschemic stroke is a disease that affects people’s health and quality of life. Cystatin C has been found as a new biomarker of cardiovascular disease. We performed this meta-analysis to assess the relationship between cystatin C and the risk of ischemic stroke. The studies on looking at the association between cystatin C and ischemic stroke were identified from inception to November 18, 2018. We performed a random-effects meta-analysis using mean difference. Nine studies with a total of 3773 ischemic stroke patients were included into the meta-analysis. Our results showed that patients with ischemic stroke had si...
Source: Journal of Molecular Neuroscience - July 16, 2019 Category: Neuroscience Source Type: research
