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Total 3873 results found since Jan 2013.

Calcium/calmodulin ‐dependent protein kinase kinase β is neuroprotective in stroke in aged mice
This study demonstrates that CaMKK β is neuroprotective following stroke in aged mice. Inhibition of CaMKK β worsened stroke outcome by reducing expression of prosurvival factors, as well as the levels of proteins important for the integrity of blood–brain barrier, and increasing proinflammatory cytokines in the serum after stroke. Conversely, the overexpression of CaMKK β reduced infarcts and behavioral deficits in aged mice.
Source: European Journal of Neuroscience - August 16, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue ‐jun Li, Louise McCullough, Jun Li Tags: Clinical and Translational Neuroscience Source Type: research

Stroke-Related Disease Comorbidity and Secondary Stroke Prevention Practices Among Young Stroke Survivors
Conclusions: Many young stroke survivors exhibit comorbid disease conditions that are similar to older stroke survivors. A large percentage are engaged in general chronic disease and secondary stroke prevention practices, yet less than two-thirds had seen a general doctor in the past 12 months. Primary care doctors and other health professionals are critical to the implementation of disease management strategies that consider their age, secondary stroke risk, expected life spans, and other issues that differ from older adult stroke survivors.
Source: Journal of Neuroscience Nursing - September 8, 2017 Category: Neuroscience Tags: Article Source Type: research

Elevated gamma-glutamyl transferase levels are associated with stroke recurrence after acute ischemic stroke or transient ischemic attack
CONCLUSION: This study demonstrated that elevated GGT levels were positively associated with an increased risk of stroke adverse outcomes, namely, recurrence, ischemic stroke, and combined vascular events.PMID:35789538 | DOI:10.1111/cns.13909
Source: CNS Neuroscience and Therapeutics - July 5, 2022 Category: Neuroscience Authors: Siqi Li Anxin Wang Xue Tian Yingting Zuo Xia Meng Yumei Zhang Source Type: research

Soluble lectin-like oxidized low-density Lipoproteinreceptor-1 and recurrent stroke: A nested case-control study
CONCLUSIONS: sLOX-1 was positively associated with the risk of recurrent stroke, which may be a candidate biomarker to improve risk stratification of recurrent stroke.PMID:35909324 | DOI:10.1111/cns.13932
Source: CNS Neuroscience and Therapeutics - August 1, 2022 Category: Neuroscience Authors: Anxin Wang Xue Tian Jie Xu Hao Li Qin Xu Pan Chen Xia Meng Yongjun Wang Source Type: research

Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
AbstractPurpose of ReviewStroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately 795,000 cases per year in the United States, of which 87% are ischemic in nature. In addition to the management of modifiable high-risk factors to reduce the risk of recurrent stroke, antithrombotic agents (antiplatelets and anticoagulants) play an important role in secondary stroke prevention. This review will discuss the published literature on the use of antiplatelets and anticoagulants in secondary prevention of acute ischemic stroke and transient ischemic attack (TIA), ...
Source: Current Neurology and Neuroscience Reports - April 11, 2023 Category: Neuroscience Source Type: research

8. Evolution and recovery of motor function post-stroke
Conclusion: Intracortical disinhibition occurs in both hemispheres immediately following acute stroke that likely represent functionally relevant changes supporting the recovery process in stroke. Whilst changes in the lesioned hemisphere persisted over the period of recovery in all patients, contralesional intracortical hyperexcitability persisted in patients with cortical strokes and those with more severe baseline functional impairment, suggesting that ongoing contralesional network recruitment may be necessary for those patients who have significant disruptions to the integrity of ipsilesional motor pathways. The study...
Source: Clinical Neurophysiology - March 3, 2014 Category: Neuroscience Authors: William Huynh, Steve Vucic, Arun V. Krishnan, Cindy S.-Y. Lin, Matthew C. Kiernan Tags: Society Proceedings Source Type: research

Targeting CD36-Mediated Inflammation Reduces Acute Brain Injury in Transient, but not Permanent, Ischemic Stroke.
CONCLUSION: The study revealed that targeting CD36 has a beneficial effect on transient but not permanent focal ischemic stroke. The study thus precludes a generalized strategy targeting CD36 in ischemic stroke and suggests careful consideration of types of stroke and associated pathology in developing stroke therapies. PMID: 25216018 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - September 12, 2014 Category: Neuroscience Authors: Kim E, Tolhurst AT, Szeto HH, Cho S Tags: CNS Neurosci Ther Source Type: research

Altered phalanx force direction during power grip following stroke.
This study characterized stroke survivors' static power grip during 100 and 50 % maximum grip. Each phalanx force angular deviation from the normal direction and its contribution to total normal force was compared for 11 stroke survivors and 11 age-matched controls. Muscle activities and skin coefficient of friction were additionally compared for another 20 stroke and 13 age-matched control subjects. The main finding was that stroke survivors gripped with a 34 % greater phalanx force angular deviation of 19° ± 2° compared to controls of 14° ± 1° (p < .05). Stroke survivors' phalanx force angular deviation ...
Source: Experimental Brain Research - March 21, 2015 Category: Neuroscience Authors: Enders LR, Seo NJ Tags: Exp Brain Res Source Type: research

Blocking Sympathetic Nervous System Reverses Partially Stroke-Induced Immunosuppression but does not Aggravate Functional Outcome After Experimental Stroke in Rats.
This study suggests that pharmacological SNS inhibition dose not aggravate functional outcome after stroke. Stroke-induced immunosuppression may be involved in the SNS-β-arrestin2-NF-κB pathway. PMID: 27059792 [PubMed - as supplied by publisher]
Source: Neurochemical Research - April 7, 2016 Category: Neuroscience Authors: Deng QW, Yang H, Yan FL, Wang H, Xing FL, Zuo L, Zhang HQ Tags: Neurochem Res Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke
Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke‐related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post‐stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, largely due to a s...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Monica S. Spychala, Pedram Honarpisheh, Louise D. McCullough Tags: Review Source Type: research

Quantitative and Qualitative EEG as a Prediction Tool for Outcome and Complications in Acute Stroke Patients.
Abstract Currently, the relevance of EEG measurements in acute stroke patients is considered low in clinical practice. However, recent studies on the predictive value of EEG measurements after stroke for various outcomes may increase the role of EEG in patients with stroke. We aimed to review the current literature on the utility of EEG measurements after stroke as a tool to predict outcome and complications, focusing on studies in which the EEG measurement was performed in the acute phase after the event and in which long-term outcome measures were reported. In our literature review, we identified 4 different out...
Source: Clinical EEG and Neuroscience - September 18, 2019 Category: Neuroscience Authors: Doerrfuss JI, Kilic T, Ahmadi M, Holtkamp M, Weber JE Tags: Clin EEG Neurosci Source Type: research

Micro RNA 181c-5p: a promising target for post-stroke recovery in socially isolated mice
Publication date: Available online 10 November 2019Source: Neuroscience LettersAuthor(s): Maria Antony, Victoria Scranton, Pranay Srivastava, Rajkumar VermaAbstractDysregulation of microRNAs (miRNAs) has been tied to several neurological disorders, including ischemic stroke. It has also been established that social environments can modulate miRNA profiles. We have previously shown that post-stroke social isolation (SI) is linked to poor stroke outcomes and that miR-181c-5p emerged as one of few lead miRNAs that was downregulated in both stroke and SI. Therefore, in this study we examined the potential role of miR-181c-5p m...
Source: Neuroscience Letters - November 11, 2019 Category: Neuroscience Source Type: research

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research