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Total 1149 results found since Jan 2013.

Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury
Ann Clin Transl Neurol. 2023 Jun 23. doi: 10.1002/acn3.51837. Online ahead of print.ABSTRACTOBJECTIVE: Accumulating studies have shown that circulating circular RNAs (circRNAs) represent novel biomarkers for many human diseases. We investigated whether plasma circPTP4A2 and circTLK2 levels are associated with stroke severity, infarct volume, stroke etiology, and functional outcome in acute ischemic stroke (AIS) patients.METHODS: We applied quantitative real-time PCR (qPCR) to measure plasma circPTP4A2 and circTLK2 levels of 236 AIS patients within 72 h of symptoms onset and 136 healthy controls. We further assessed the Nat...
Source: Atherosclerosis - June 23, 2023 Category: Cardiology Authors: Xingzhi Wang Shenyang Zhang Zuohui Zhang Jie Zu Hongjuan Shi Lu Yu Bingchen Lv Likun Cui Wenqi Mao Di Wu Guiyun Cui Source Type: research

Death and ADL Dependency After Scoring Zero on the NIHSS: A Swedish Retrospective Registry-Based Study
Discussion One of 17 patients has either died or become ADL-dependent 3 months after a 0-NIHSS stroke, stressing that these strokes are not always benign. Older and physically inactive patients are at greater risk of an adverse outcome.
Source: Neurology Clinical Practice - September 1, 2023 Category: Neurology Authors: Darehed, D., Reinholdsson, M., Viktorisson, A., Abzhandadze, T., Sunnerhagen, K. S. Tags: Outcome research, All Cerebrovascular disease/Stroke, Cohort studies Research Article Source Type: research

Prognostic Value of Plasma Neuroendocrine Biomarkers in Patients with Acute Ischaemic Stroke
Inflammation and activation of the neuroendocrine systems comprise important aspects of stroke pathophysiology. The present study investigated whether baseline plasma brain natriuretic peptide (BNP), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), cortisol and copeptin levels on admission can predict short‐term outcomes and mortality after acute ischaemic stroke. The study group consisted of 189 patients who had their first acute ischaemic stroke. Plasma levels of BNP, NT‐proBNP, cortisol and copeptin were evaluated to determine their value with respect to predicting functional outcome and mortality within ...
Source: Journal of Neuroendocrinology - August 20, 2013 Category: Endocrinology Authors: W.‐J. Tu, X. Dong, S.‐J. Zhao, D.‐G. Yang, H. Chen Tags: Original Article Source Type: research

Study protocol: prediction of stroke associated infections by markers of autonomic control
DiscussionSince a general prophylactic antibiotic treatment after stroke is not recommended, results of this study could have essential implications for an early identification and hence, timely appropriate treating of stroke-induced infections.Trial registration: Pradiktoren fur die Sepsis - Pred Sep, German Clinical Trials Register: DRKS00003392.
Source: BMC Neurology - January 13, 2014 Category: Neurology Authors: Dirk BrämerHeike HoyerAlbrecht GüntherSamuel NowackFrank BrunkhorstOtto WitteDirk Hoyer Source Type: research

Outdoor air pollution, subtypes and severity of ischemic stroke - a small-area level ecological study
We examined associations between outdoor PM10 and NO2 concentrations modeled at a fine spatial resolution and etiological and clinical ischemic stroke subtypes and severity of ischemic stroke. Methods: We used a small-area level ecological study design and a stroke register set up to capture all incident cases of first ever stroke (1995-2007) occurring in a defined geographical area in South London (948 census output areas; population of 267839). Modeled PM10 and NO2 concentrations were available at a very fine spatial scale (20 meter by 20 meter grid point resolution) and were aggregated to output area level using postcod...
Source: International Journal of Health Geographics - June 17, 2014 Category: Global & Universal Authors: Ravi MaheswaranTim PearsonSean BeeversMichael CampbellCharles Wolfe Source Type: research

Outdoor air pollution, subtypes and severity of ischemic stroke ¿ a small-area level ecological study
We examined associations between outdoor PM10 and NO2 concentrations modeled at a fine spatial resolution and etiological and clinical ischemic stroke subtypes and severity of ischemic stroke. Methods: We used a small-area level ecological study design and a stroke register set up to capture all incident cases of first ever stroke (1995–2007) occurring in a defined geographical area in South London (948 census output areas; population of 267839). Modeled PM10 and NO2 concentrations were available at a very fine spatial scale (20 meter by 20 meter grid point resolution) and were aggregated to output area level using postc...
Source: International Journal of Health Geographics - June 17, 2014 Category: Global & Universal Authors: Ravi MaheswaranTim PearsonSean BeeversMichael CampbellCharles Wolfe Source Type: research

Multifactorial Analysis of Factors Affecting Recurrence of Stroke in Japan
Data on factors affecting stroke recurrence are relatively limited. The authors examined potential factors affecting stroke recurrence, retrospectively. The study participants were 1087 patients who were admitted to stroke centers suffering from first-ever ischemic stroke and returned questionnaires with usable information after discharge. The authors analyzed the association between clinical parameters of the patients and their prognosis. Recurrence rate of during an average of 2 years after discharge was 21.3%, and there were differences among stroke subtypes. It was found that the disability level of the patients after ...
Source: Asia-Pacific Journal of Public Health - March 31, 2015 Category: Global & Universal Authors: Omori, T., Kawagoe, M., Moriyama, M., Yasuda, T., Ito, Y., Hyakuta, T., Nagatsuka, K., Matsumoto, M. Tags: E-articles Source Type: research

Increased High-Sensitivity Troponin-T Levels Are Associated with Mortality After Ischemic Stroke
This study indicates that elevated troponin is an independent marker for severe deficits on presentation and for mortality in stroke patients.
Source: Journal of Molecular Neuroscience - June 11, 2015 Category: Neuroscience Source Type: research

Impact of early enteral nutrition on short term prognosis after acute stroke
Publication date: Available online 14 July 2015 Source:Journal of Clinical Neuroscience Author(s): Tianheng Zheng , Xinpu Zhu , Huazheng Liang , Haixia Huang , Jiandao Yang , Shaoshi Wang We hypothesized that early enteral nutritional support would improve the short term prognosis of acute stroke patients with dysphagia, demonstrated by lower malnutrition rates, lower complication rates, and lower National Institutes of Health Stroke Scale (NIHSS) scores at 90days post stroke. Nutrition support is an essential element in the care of stroke patients and many studies have investigated the effect of specific nutritional ele...
Source: Journal of Clinical Neuroscience - July 14, 2015 Category: Neuroscience Source Type: research

Influence of previous physical activity on the outcome of patients treated by thrombolytic therapy for stroke
Abstract Physical activity prevents stroke and is associated with less severe strokes. The neuroprotective effect in patients treated with intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA), remains uncertain. We aimed at evaluating the relationship between previous physical activity and outcomes in stroke patients treated with i.v. rt-PA. OPHELIE-SPORT was a prospective observational multicenter study conducted in French and Japanese stroke patients treated with i.v. rt-PA. We evaluated the presence, weekly duration (<2, 2–5, >5 h) and intensity (light, moderate, heavy) of previous leisu...
Source: Journal of Neurology - August 14, 2015 Category: Neurology Source Type: research

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials
Publication date: Available online 18 February 2016 Source:The Lancet Author(s): Mayank Goyal, Bijoy K Menon, Wim H van Zwam, Diederik W J Dippel, Peter J Mitchell, Andrew M Demchuk, Antoni Dávalos, Charles B L M Majoie, Aad van der Lugt, Maria A de Miquel, Geoffrey A Donnan, Yvo B W E M Roos, Alain Bonafe, Reza Jahan, Hans-Christoph Diener, Lucie A van den Berg, Elad I Levy, Olvert A Berkhemer, Vitor M Pereira, Jeremy Rempel, Mònica Millán, Stephen M Davis, Daniel Roy, John Thornton, Luis San Román, Marc Ribó, Debbie Beumer, Bruce Stouch, Scott Brown, Bruce C V Campbell, Robert J van ...
Source: The Lancet - February 19, 2016 Category: Journals (General) Source Type: research

The Number of Stenotic Intracranial Arteries Is Independently Associated with Ischemic Stroke Severity
by Xiaodan Wei, Zhuang Liu, Min Li, Chunhua Yang, Wenming Wang, Xianglin Li, Shuping Zhang, Xuri Li, Geng Tian, Jonas Bergquist, Bin Wang, Jia Mi BackgroundThe severity of ischemic stroke symptoms varies among patients and is a critical determinant of patient outcome. To date, the association between the number of stenotic intracranial arteries and stroke severity remains unclear. AimsWe aimed to investigate the association between the number of stenotic major intracranial arteries (NSMIA) and ischemic stroke severity, as well as the degree of stenosis and common stroke risk factors. MethodsWe performed a retrospective ana...
Source: PLoS One - September 19, 2016 Category: Biomedical Science Authors: Xiaodan Wei Source Type: research

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial
This study is registered with ClinicalTrials.gov, number NCT01436487. Findings The study was done between Oct 24, 2011, and Dec 7, 2015. After safety assessments in eight patients in group 1, 129 patients were randomly assigned (67 to receive multipotent adult progenitor cells and 62 to receive placebo) in groups 2 and 3 (1200 million cells). The ITT populations consisted of 65 patients who received multipotent adult progenitor cells and 61 patients who received placebo. There were no dose-limiting toxicity events in either group. There were no infusional or allergic reactions and no difference in treatment-emergent advers...
Source: The Lancet Neurology - March 17, 2017 Category: Neurology Source Type: research

National Institutes of Health Stroke Scale in Plain English Is Reliable for Novice Nurse Users with Minimal Training
Discussion With minimal or no training, novice nurse users of the NIHSS-PE can do as well as, if not better than, novice users of the NIHSS, making this tool useful for facilities pursuing Acute Stroke-Ready certification.
Source: Journal of Emergency Nursing - March 28, 2017 Category: Nursing Source Type: research

Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial
This study is registered with ClinicalTrials.gov, number NCT01949948. Findings Between Sept 1, 2012, and Sept 30, 2016, 1107 patients met the inclusion criteria and seven patients were excluded because informed consent was withdrawn or eligibility for thrombolytic treatment was reconsidered. 1100 patients were randomly assigned to the tenecteplase (n=549) or alteplase (n=551) groups. The median age of participants was 77 years (IQR 64–79) and the median National Institutes of Health Stroke Scale score at baseline was 4 points (IQR 2–8). A final diagnosis other than ischaemic stroke or transient ischaemic attack was fou...
Source: The Lancet Neurology - August 3, 2017 Category: Neurology Source Type: research