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Total 1149 results found since Jan 2013.
Biomaterial developed at UCLA helps regrow brain tissue after stroke in mice
A new stroke-healing gel created by UCLA researchers helped regrow neurons and blood vessels in mice whose brains had been damaged by strokes.The finding is reported May 21 in Nature Materials.“We tested this in laboratory mice to determine if it would repair the brain and lead to recovery in a model of stroke,” said Dr. S. Thomas Carmichael, professor of neurology at theDavid Geffen School of Medicine at UCLA. “The study indicated that new brain tissue can be regenerated in what was previously just an inactive brain scar after stroke.”The results suggest that such an approach could some day be used to treat people...
Source: UCLA Newsroom: Health Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: news
Predictive Role of hsCRP in Recurrent Stroke Differed According to Severity of Cerebrovascular Disease: Analysis from a Prospective Cohort Study
J Clin Med. 2023 Feb 20;12(4):1676. doi: 10.3390/jcm12041676.ABSTRACTElevated levels of high-sensitivity C-reactive protein (hsCRP) were associated with an increased risk of recurrent stroke. However, it is still unknown whether the predictive value of hsCRP differed according to the severity of cerebrovascular disease. We used the cohort of the prospective multicenter cohort study of the Third China National Stroke Registry (CNSR-III), in which 10,765 consecutive patients with acute ischemic stroke or transient ischemic attack (TIA) had hsCRP levels measured. Patients were classified into minor stroke, or TIA, and non-min...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Jiejie Li Yuesong Pan Mengxing Wang Xia Meng Jinxi Lin Zixiao Li Hao Li Yilong Wang Xingquan Zhao Liping Liu Yongjun Wang Source Type: research
Clinical significance of CT angiographic assessment of collateral circulation combined with serum NLRP1 levels in ischemic stroke patients
This study showed that the serum NLRP1 levels were remarkably decreased in ischemic stroke patients. In addition, the serum NLRP1 levels and ASITN/SIR grade could predict the prognosis of ischemic stroke patients.PMID:37000063 | DOI:10.1097/MD.0000000000033433
Source: Atherosclerosis - March 31, 2023 Category: Cardiology Authors: Chong Tao Yu Wang Shiyin Xiao Source Type: research
UCLA brain-imaging tool and stroke risk test help identify cognitive decline early
UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia.
The connection between stroke risk and cognitive decline has been well established by previous research. Individuals with higher stroke risk, as measured by factors like high blood pressure, have traditionally performed worse on tests of memory, attention and abstract reasoning.
The current small study demonstrated that not only stroke risk, but also the burden of plaques and tangles, as measured by a UCLA brain scan, may influence c...
Source: UCLA Newsroom: Health Sciences - April 3, 2013 Category: Universities & Medical Training Source Type: news
Early High-dosage Atorvastatin Treatment Improved Serum Immune-inflammatory Markers and Functional Outcome in Acute Ischemic Strokes Classified as Large Artery Atherosclerotic Stroke: A Randomized Trial
Abstract: Statins have beneficial effects on cerebral circulation and brain parenchyma during ischemic stroke and reperfusion. The primary hypothesis of this randomized parallel trial was that treatment with 80 mg/day of atorvastatin administered early at admission after acute atherosclerotic ischemic stroke could reduce serum levels of markers of immune-inflammatory activation of the acute phase and that this immune-inflammatory modulation could have a possible effect on prognosis of ischemic stroke evaluated by some outcome indicators.
We enrolled 42 patients with acute ischemic stroke classified as large arteries ath...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Mean Platelet Volume During Ischemic Stroke Is A Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome.
Abstract
The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and in large, more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting, Studies are not currently available on the association between MPV and stroke recovery after neurorehabilitation. The relationship between MPV and clinical and functional outcome measures was assessed in twenty-four patients in the acute phase of first-ever ischemic stroke, and before and after 8-week intensive multifunctional neurorehabilitation. Neurorehabilitation was associated with improve...
Source: Current Neurovascular Research - May 16, 2016 Category: Neurology Authors: Ciancarelli I, De Amicis D, Di Massimo C, Pistarini C, Ciancarelli MG Tags: Curr Neurovasc Res Source Type: research
Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study
Publication date: Available online 26 February 2018 Source:The Lancet Global Health Author(s): Mayowa O Owolabi, Fred Sarfo, Rufus Akinyemi, Mulugeta Gebregziabher, Onoja Akpa, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Lukman Owolabi, Bruce Ovbiagele Background Sub-Saharan Africa has the highest incidence, prevalence, and fatality from stroke globally. Yet, only little information about context-specific risk factors for prioritising interventions to reduce the stroke burden in sub-Saharan Africa is available. We aimed to identify and characterise the effect of the top modifiable risk factors for stroke in sub-Sahara...
Source: The Lancet Global Health - February 27, 2018 Category: International Medicine & Public Health Source Type: research
Thrombectomy in stroke of unknown onset, wake up stroke and late presentations: Australian experience from 2 comprehensive stroke centres
This study shows good ‘real world’ outcomes, comparable to published RCTs, in patients with unknown-onset, or late presentation, stroke treated with EVT more than 6 h from stroke onset.
Source: Journal of Clinical Neuroscience - November 8, 2018 Category: Neuroscience Source Type: research
Drip-and-Ship for Thrombectomy Treatment in Patients With Acute Ischemic Stroke Leads to Inferior Clinical Outcomes in a Stroke Network Covering Vast Rural Areas Compared to Direct Admission to a Comprehensive Stroke Center
Discussion: Our data suggest that patients who had an acute ischemic stroke admitted directly to a CSC may have better 90-day outcomes than those transferred secondarily for thrombectomy from a PSC.
Source: Frontiers in Neurology - November 1, 2021 Category: Neurology Source Type: research
Trial of a prehospital intervention with traditional Chinese medicine for acute stroke (TRACE): Protocol for a mixed-methods research study
Discussion: The results of the TRACE study will provide preliminary evidence for the relationship between XNJI used within 24 h of onset and the presence of END on the third day after stroke onset; it will aid in improving the current knowledge regarding the early use of XNJI for stroke first aid.Clinical Trial Registration:clinicaltrials.gov, identifier NCT04275349
Source: Frontiers in Pharmacology - August 29, 2022 Category: Drugs & Pharmacology Source Type: research
Factors Predicting Misidentification of Acute Ischemic Stroke and Large Vessel Occlusion by Paramedics
The emergence of thrombectomy for large vessel occlusions has increased the importance of accurate prehospital identification and triage of acute ischemic stroke (AIS). Despite available clinical scores, prehospital identification is suboptimal. Our objective was to improve the sensitivity of prehospital AIS identification by combining dispatch information with paramedic impression. We performed a retrospective cohort review of emergency medical services and hospital records of all patients for whom a stroke alert was activated in 1 urban, academic emergency department from January 1, 2018, to December 31, 2019. Using admi...
Source: Critical Pathways in Cardiology - November 24, 2022 Category: Cardiology Tags: Original Study Source Type: research
CHIMES‐I: sub‐group analyzes of the effects of NeuroAiD according to baseline brain imaging characteristics among patients randomized in the CHIMES study
RationaleThe clinical effects of neuroprotective and/or neurorestorative therapies may vary according to location and size of the ischemic injury. Imaging techniques can be useful in stratifying patients for trials that may be beneficial against particular ischemic lesion characteristics.
AimTo test the hypothesis that the efficacy of NeuroAiD compared with placebo in improving functional outcome and reducing neurological deficit in patients with cerebral infarction of intermediate severity varies between sub‐groups of patients randomized in the main Chinese Medicine Neuroaid Efficacy on Stroke study when categorized acc...
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Jose C. Navarro, Christopher Chen Li Hsian, Pedro Danilo J. Lagamayo, Melodia B. Geslani, Gaik Bee Eow, Niphon Poungvarin, Asita Silva, Lawrence K. S. Wong, N. Venketasubramanian, Tags: Protocol Source Type: research
A pilot study of respiratory muscle training to improve cough effectiveness and reduce the incidence of pneumonia in acute stroke: study protocol for a randomized controlled trial
This study investigates a novel strategy based on an exercise intervention for cough rehabilitation.Trial registration: Current Controlled Trials ISRCTN40298220
Source: BioMed Central - April 12, 2014 Category: Journals (General) Authors: Stefan Tino KulnikGerrard Francis RaffertySurinder S BirringJohn MoxhamLalit Kalra Source Type: research
Innovation in Stroke Care Quality: NIH Stroke Scale Change and Shewhart Charts
Stroke care, admission through discharge, is a process that should lead to symptomatic improvement. Improvement or decline in conditions of patients with acute stroke during hospitalization can be measured by the National Institutes of Health Stroke Scale (NIH Stroke Scale or NIHSS) at both admission and discharge and may indicate the overall quality of acute stroke care for a patient and the stability of care in the system. Shewhart control charts were analyzed for 98 patients with stroke admissions in a random sample at a tertiary care stroke center to determine the feasibility of examining the NIHSS score change to dete...
Source: Quality Management in Healthcare - July 1, 2015 Category: Health Management Tags: Original Articles Source Type: research
