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Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis? Clinical Sciences
Conclusions— In children with dissection and transient cerebral arteriopathy, cerebral arteries demonstrate increased tortuosity. Quantified arterial tortuosity may represent a clinically relevant imaging biomarker of vascular biology in pediatric stroke.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Wei, F., Diedrich, K. T., Fullerton, H. J., deVeber, G., Wintermark, M., Hodge, J., Kirton, A., the Vascular Effects of Infection in Pediatric Stroke (VIPS) Investigators, Dowling, Benedict, Bernard, Fox, Friedman, Lo, Ichord, Tan, Mackay, Hernandez, Hump Tags: Risk Factors, Angiography, Magnetic Resonance Imaging (MRI), Ischemic Stroke, Vascular Disease Clinical Sciences Source Type: research

Pediatric Acute Stroke Protocol Activation in a Children's Hospital Emergency Department Brief Reports
Conclusions— Of pediatric brain attacks, 24% were stroke, 2% were transient ischemic attack, and 14% were other neurological emergencies. Together, 40% had a stroke or other neurological emergency, underscoring the need for prompt evaluation and management of children with brain attacks.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Ladner, T. R., Mahdi, J., Gindville, M. C., Gordon, A., Harris, Z. L., Crossman, K., Pruthi, S., Abramo, T. J., Jordan, L. C. Tags: Emergency treatment of Stroke, Stroke in Children and the Young Brief Reports Source Type: research

Timing and number of minor infections as risk factors for childhood arterial ischemic stroke
Conclusions: Minor infections appear to have a strong but short-lived effect on pediatric stroke risk, while cumulative burden of infection had no effect. Proposed mechanisms for the link between minor infection and stroke in adults include an inflammatory-mediated prothrombotic state and chronic endothelial injury. The transient effect of infection in children may suggest a greater role for a prothrombotic mechanism.
Source: Neurology - September 1, 2014 Category: Neurology Authors: Hills, N. K., Sidney, S., Fullerton, H. J. Tags: Childhood stroke, All Infections, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, Case control studies ARTICLE Source Type: research

Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations
Conclusions: SIIA are detectable on admission of acute stroke patients. While it was assumed that post-stroke immunosuppression is rapidly reversed with improvement this is the first data set that shows that improvement actually is associated with a rapid reversal of SIIA demonstrating that SIIA require a constant signal to persist. The observation that HMGB-1 serum concentrations were similar in improved and non-improved cohorts argues against a role for this pro-inflammatory mediator in the maintenance of SIIA. Serum miRNA observed to be regulated in stroke in other publications was counter regulated with improvement in ...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

What Are the Classifications of Perinatal Stroke?
Discussion Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

The Risk of Large-Artery Atherosclerotic Stroke is Proportionally Greater than Cardioembolic Stroke in HIV-Infected Individuals Compared to HIV-Uninfected Controls (P4.304)
CONCLUSIONS: HIV-infected individuals with well-controlled infection may be at proportionally greater risk for large artery atherosclerotic versus cardioembolic stroke compared to uninfected individuals. Additional studies are warranted to confirm this association and explore potential mechanisms underlying this difference, including the role of chronic inflammation.Disclosure: Dr. Price has received personal compensation for activities with Abbott Laboratories as a speaker. Dr. Hsue has nothing to disclose. Dr. Kim has received research support from SanBio, Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chow, F., Price, R., Hsue, P., Kim, A. Tags: NeuroAIDS Source Type: research

The Risk of Large-Artery Atherosclerotic Stroke is Proportionally Greater than Cardioembolic Stroke in HIV-Infected Individuals Compared to HIV-Uninfected Controls (I10-1.003)
CONCLUSIONS: HIV-infected individuals with well-controlled infection may be at proportionally greater risk for large artery atherosclerotic versus cardioembolic stroke compared to uninfected individuals. Additional studies are warranted to confirm this association and explore potential mechanisms underlying this difference, including the role of chronic inflammation.Disclosure: Dr. Price has received personal compensation for activities with Abbott Laboratories as a speaker. Dr. Hsue has nothing to disclose. Dr. Kim has received research support from SanBio, Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chow, F., Price, R., Hsue, P., Kim, A. Tags: The Global Burden of Neurological Diseases Poster Presentations Source Type: research

Stroke Subtypes and Risk Factors in Saudi Arabia (P1.124)
CONCLUSION: Non-cardioembolic disease was the overwhelming stroke mechanism in this middle-eastern cohort with only 4[percnt] of patients have cardioembolic stroke, in comparison to roughly 20[percnt] reported in Western cohorts. In part, these differences may be explained by deficient prolonged cardiac monitoring. However the high prevalence of atherothrombotic risk factors and overrepresentation of non-cardioembolic stroke suggests a need to optimize atherothrombotic stroke risk factor management within our populationDisclosure: Dr. Al Harbi has nothing to disclose. Dr. Shoamanesh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Al Harbi, A., Shoamanesh, A. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

Stroke in patients with tuberculous meningitis in a low TB endemic country: an increasing medical emergency?
This study evaluated the frequency, clinical characteristics, risk factors and outcomes of patients with TBM complicated by stroke admitted to the Infectious Disease Clinic, University of Perugia Hospital, Italy from 1971 to 2010. Over four decades, 419 patients were admitted with tuberculosis, of these 30 (7.1%) were diagnosed with TBM: 20 definite, one probable and nine possible. Twenty-six were evaluable for stroke and six (23%) had stroke. The latter six had advanced stages of meningitis, two tested HIV positive, three HIV negative and in one HIV was not performed. Of seven patients without stroke tested for HIV, only ...
Source: New Microbiologica - December 1, 2014 Category: Microbiology Tags: New Microbiol Source Type: research

Association of HIV and Opportunistic Infections With Incident Stroke: A Nationwide Population-Based Cohort Study in Taiwan
Conclusions: Patients with HIV had an increased risk of stroke, particularly those with cryptococcal meningitis, cytomegalovirus, or P. marneffei infection.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - January 12, 2017 Category: Infectious Diseases Tags: Epidemiology Source Type: research

Stroke in paediatric patients with sickle-cell anaemia.
CONCLUSIONS. Drepanocytosis is a disease that is emerging in our setting as a result of immigration. It should be suspected in cases of paediatric strokes associated to anaemia, above all in black children under the age of five who were not submitted to neonatal screening. PMID: 25059265 [PubMed - in process]
Source: Revista de Neurologia - July 29, 2014 Category: Neurology Authors: Diaz-Diaz J, Camacho-Salas A, Nunez-Enamorado N, Carro-Rodriguez MA, Sanchez-Galan V, Martinez de Aragon A, Simon-De Las Heras R Tags: Rev Neurol Source Type: research

Hypovolemia due to cerebral salt wasting may contribute to stroke in tuberculous meningitis
ConclusionIn TBM, stroke occurred in 39.5% of the patients, 50% of whom had CSW. Volume contraction due to CSW may contribute to stroke.
Source: QJM - April 9, 2018 Category: Internal Medicine Source Type: research

Ischemic stroke and infectious diseases in low-income and middle-income countries
Purpose of review To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries. Recent findings Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Infectious diseases and stroke have a bidirectional relationship. Common infections m...
Source: Current Opinion in Neurology - January 13, 2019 Category: Neurology Tags: CEREBROVASCULAR DISEASE: Edited by Didier Leys Source Type: research

Antithrombotic Therapy for Secondary Stroke Prevention in Bacterial Meningitis in Children
Conclusion: In this small sample, heparin and ASA appeared to be safe in childhood bacterial meningitis complicated by stroke and may be effective in improving outcome. Heparin may be more effective than aspirin in preventing recurrent infarction.
Source: The Journal of Pediatrics - July 24, 2014 Category: Pediatrics Authors: Cyrus Boelman, Manohar Shroff, Ivanna Yau, Bruce Bjornson, Susan Richrdson, Gabrielle deVeber, Daune MacGregor, Mahendranathn Moharir, Rand Askalan Tags: Original Articles Source Type: research

Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study PEDIATRICS
CONCLUSIONS: Childhood arteriopathy subtypes have some typical features that aid diagnosis. Better imaging methods, including vessel wall imaging, are needed for improved classification of focal cerebral arteriopathy of childhood.
Source: American Journal of Neuroradiology - November 15, 2017 Category: Radiology Authors: Wintermark, M., Hills, N. K., DeVeber, G. A., Barkovich, A. J., Bernard, T. J., Friedman, N. R., Mackay, M. T., Kirton, A., Zhu, G., Leiva-Salinas, C., Hou, Q., Fullerton, H. J., the VIPS Investigators Tags: PEDIATRICS Source Type: research

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