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Infectious Disease: Meningitis
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Total 171 results found since Jan 2013.

Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillBärnighaus...
Source: The Lancet Neurology - September 19, 2017 Category: Neurology Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Central Nervous System Complications of Varicella-Zoster Virus
Conclusion: Neurologic complications of VZV infection continue to occur despite the availability of an effective vaccine. Neurologic symptom onset can predate the appearance of the VZV exanthem and in rare cases may occur in the absence of an exanthem.
Source: The Journal of Pediatrics - July 24, 2014 Category: Pediatrics Authors: Michelle Science, Daune MacGregor, Susan E. Richardson, Sanjay Mahant, Dat Tran, Ari Bitnun Tags: Original Articles Source Type: research

A Case Report of Rheumatoid Meningitis, an unusual complication of Rheumatoid Arthritis (P4.056)
CONCLUSIONS: Rheumatoid Meningitis is an extremely uncommon complication of Rheumatoid Arthritis. Initial presentations can vary from altered mental status (most common), cranial neuropathies, hemiparesis/paraparesis, seizure, headache and very rarely stroke like symptoms. This patient with Rheumatoid Arthritis presented with multiple stroke like episodes, lepomeningeal enhancement. Diagnosis was established on the basis of Imaging and Histopathology after excluding other potential causes of granulomatous meningitis. Study Supported by: Not applicableDisclosure: Dr. roy has nothing to disclose. Dr. Brink has nothing to dis...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Roy, B., Brink, J., Bakradze, E., Al Zahmi, F., Uphoff, D., Silverman, I. Tags: MS and CNS Inflammatory Diseases: CNS Inflammatory Diseases and Differential Diagnosis Source Type: research

Predictors of Poor Outcome in Bacterial Meningitis: Retrospective Analysis of Nationwide Inpatient Sample (P5.046)
CONCLUSIONS: In this retrospective study, every decade increase in age, teaching hospital status and development of complications like hydrocephalus, ischemic stroke, seizures, intracranial abscess and respiratory failure were predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Dharaiya has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Maraka has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dharaiya, D., Modi, S., Maraka, S. Tags: Neuroepidemiology: Headache, Global Health, and Infectious Disease Source Type: research

UCLA researchers provide first evidence of how obstructive sleep apnea damages the brain
Courtesy of Rajesh Kumar Brains with obstructive sleep apnea (left) and without UCLA researchers have reported the first evidence that obstructive sleep apnea contributes to a breakdown of the blood–brain barrier, which plays an important role in protecting brain tissue. The discovery, reported in the Sept. 1 issue of the Journal of Neuroimaging, could lead to new approaches for treating obstructive sleep apnea, which affects an estimated 22 million American adults. The disorder causes frequent interruptions in breathing during sleep because the airways narrow or become blocked. The blood–brain barrier limits harmful...
Source: UCLA Newsroom: Health Sciences - September 1, 2015 Category: Universities & Medical Training Source Type: news

Trends and Characteristics of Tuberculous Meningitis in the United States, 1993-2013 (S30.007)
Conclusions:Over the past two decades, the incidence and mortality of TBM in the US have steadily declined, but neurological complications are increasing.Study Supported by:This work was supported by the National Institute of Neurological Disorders [grant numbers K23NS082367, R01NS097443-01 to H.K.] and the Michael Goldberg Stroke Research Fund to [H.K.].Disclosure: Dr. Merkler has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Gialdini has nothing to disclose. Dr. Reynolds has nothing to disclose. Dr. Morris has nothing to disclose. Dr. Murthy has nothing to disclose. Dr. Thakur has received personal com...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Chatterjee, A., Gialdini, G., Reynolds, A., Morris, N., Murthy, S., Thakur, K., Kamel, H. Tags: Infectious Disease: HIV, Syphilis, Borrelia, TB, Cysticercosis, and Other Infections Source Type: research

Spectrum of hyperosmolar hyperglycaemic state in neurology practice.
Abstract Background & objectives: Hyperosmolar hyperglycaemic state (HHS) is a medical emergency, but there is a paucity of studies reporting the spectrum of neurological manifestations of HHS. We, therefore, report the neurological spectrum, triggering factors and outcome of HHS in general neurology practice. Methods: The records of the patients with HHS were extracted from computerized hospital information system and those managed currently were prospectively included. The demographic, clinical manifestations, duration of diabetes and precipitating events such as infection, stress and stroke were noted....
Source: The Indian Journal of Medical Research - November 1, 2017 Category: Biomedical Science Authors: Misra UK, Kalita J, Bhoi SK, Dubey D Tags: Indian J Med Res Source Type: research

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Inj...
Source: The Lancet Neurology - March 16, 2019 Category: Neurology Source Type: research

Assessment of pre-specified adverse events following varicella vaccine: A population-based self-controlled risk interval study.
CONCLUSIONS: We detected a small risk of incidental pneumonia associated with varicella vaccine in the 6th week after immunization. There was no increase in the risk of other pre-specified adverse events. PMID: 32046891 [PubMed - as supplied by publisher]
Source: Vaccine - February 7, 2020 Category: Allergy & Immunology Authors: Liu CH, Yeh YC, Huang WT, Chie WC, Chan KA Tags: Vaccine Source Type: research

Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India.
CONCLUSION: No single biomarker correlated with NPSLE. Among different NPSLE manifestations, the prevalence of IgG β2GP1 in stroke, LA in demyelination, anti-ribosomal P in psychosis and anti-myelin oligodendrocyte glycoprotein in mood disorder were higher. Further studies on the pathogenic mechanisms underlying NPSLE and its different manifestations may help us to identify better biomarkers. PMID: 32106787 [PubMed - as supplied by publisher]
Source: Lupus - February 26, 2020 Category: Rheumatology Authors: Seth G, Sundaresh A, Mariaselvam CM, Kumar G, Chengappa KG, Adarsh MB, Tamouza R, Negi VS Tags: Lupus Source Type: research

Neurological manifestations in COVID-19: a systematic review and meta-analysis.
CONCLUSIONS: Stroke is the most frequently reported neurological manifestation in COVID-19 and has the highest mortality rate. Neurological manifestations tend to develop one to two weeks after the onset of respiratory disease. There is significant morbidity and mortality associated with COVID-19 neurological manifestations. PMID: 33074036 [PubMed - as supplied by publisher]
Source: Brain Injury - October 22, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Predictive Factors of Central Nervous Infection: Prospective Evaluation of 124 Cases with Suspicion of Meningitis. (P2.303)
Discussion and conclusions: The presence of meningeal signs, hypoglucorraquia and low PH in CSF are the most suggestive findings of meningitis, when compared to fever, mental status changes or other variables. Initial CSF image should include the application of constrast when possible.Disclosure: Dr. Trevino has nothing to disclose. Dr. Gonzalez Duarte has nothing to disclose. Dr. Avila-Funes has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Trevino, I., Gonzalez Duarte, M. A., Avila-Funes, A. Tags: CNS Infectious Disease: Miscellaneous Source Type: research

Resolution of a fungal mycotic aneurysm after a contaminated steroid injection: a case report
Conclusions: This is the rare case report of successful medical management of a cerebral mycotic aneurysm with stroke symptoms related to a presumed phaeohyphomycosis in an immunocompetent individual. Further studies are needed to determine the utility of cerebrospinal fluid (1, 3) beta-D-glucan in diagnosing and monitoring patients with meningitis thought to be related to fungal infection.
Source: BMC Research Notes - May 31, 2014 Category: Research Authors: George NelsonOlga FermoKiran ThakurElizabeth FeltonJee BangLucy WilsonSusan RheeRafael LlinasKristine JohnsonDavid Sullivan Source Type: research

The value of C-reactive protein in emergency medicine
Publication date: 2014 Source:Journal of Acute Disease, Volume 3, Issue 1 Author(s): Yu-Jang Su C-reactive protein (CRP) is a commonly used tool in emergency department (ED), especially in febrile and infectious patients. It was identified in 1930 and was subsequently classified into an “acute phase protein”, an early indicator of infectious or inflammatory situations in the ED, CRP must be a diagnostic reference and no single value can be indicated to rule in or rule out a specific diagnosis or disease. CRP is a comprehensively assisted tool for evaluation and diagnosis of tissue damage (rheumatologic diseases, stro...
Source: Journal of Acute Disease - November 2, 2014 Category: Emergency Medicine Source Type: research