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Epidemiology, investigation, management, and outcome  of headache in emergency departments (HEAD study)-A multinational observational study
CONCLUSION: Diagnosis and management of headache in the ED is challenging. A small group of patients have a serious secondary cause for their symptoms. There is wide variation in the use of neuroimaging and treatments. Further work is needed to understand the variation in practice and to better inform international guidelines regarding emergent neuroimaging and treatment.PMID:34726783 | DOI:10.1111/head.14230
Source: Headache - November 2, 2021 Category: Neurology Authors: Anne Maree Kelly Win Sen Kuan Kevin H Chu Frances B Kinnear Gerben Keijzers Mehmet A Karamercan Sharon Klim Tissa Wijeratne Sinan Kamona Colin A Graham Richard Body Tom Roberts Daniel Horner Said Laribi and the HEAD Study Group Source Type: research

POSA199 Risk of Cardiovascular Events after Streptococcus Pneumoniae Infections: Life Study
Streptococcus pneumoniae is a common cause of diseases such as community-acquired pneumonia, meningitis, and sepsis across all age groups. In Japan, routine pneumococcal vaccinations are carried out for children aged ≤5 years and older persons aged ≥65 years due to their higher risk of infection. Acute S. pneumoniae infections are reported to elevate the risk of subsequent cardiovascular events such as coronary heart disease, heart failure, arrhythmia, and stroke. In order to generate evidence for the develo pment of optimal vaccination strategies, this study analyzed the effects of S.
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Authors: N Nishimura, H Fukuda Source Type: research

Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury
Conclusions Amantadine treatment is associated with improved consciousness among patients with different types of non-traumatic brain injury in this observational cohort analysis. Epileptic seizures should be considered as potential side effects and randomised controlled trials are needed to confirm these findings.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Rühl, L., Kuramatsu, J. B., Sembill, J. A., Kallmünzer, B., Madzar, D., Gerner, S. T., Giede-Jeppe, A., Balk, S., Mueller, T., Jäger, J., Schwab, S., Huttner, H. B., Sprügel, M. I. Tags: Open access Cerebrovascular disease Source Type: research

Early Intracranial Hemorrhage Predicts Poor Clinical Outcome in Community-Acquired Bacterial Meningitis
ConclusionEarly cerebral hemorrhage (ECHO) is a potential prognostic marker for clinicians confronted with decision-making in patients who are critically ill with community-acquired bacterial meningitis.
Source: Frontiers in Neurology - June 16, 2022 Category: Neurology Source Type: research

Cerebrospinal Fluid Flow Analysis in Tuberculous Meningitis Using Phase Contrast Technique on 3 Tesla MRI: A New Paradigm and Our Initial Experience
Conclusion: PC-MRI is a sensitive technique to analyze altered CSF flow dynamics in tuberculous meningitis patients. This is a useful adjunct in imaging these patients to extract both the qualitative and quantitative information about CSF flow for comprehensive evaluation.
Source: Neurology India - July 1, 2022 Category: Neurology Authors: Aanchal Ashta Anjali Prakash Rashmi Dixit Naresh Kumar Source Type: research

Prevention of neurological complications during COVID-19: a retrospective analysis of the ISARIC4C national cohort
This study is the first to focus on the prevention of neurological complications and strongly supports the continued use of both dexamethasone and remdesivir in severe COVID-19. Our results suggest that the established benefit of dexamethasone on mortality in COVID-19 is not associated with an increased burden of long-term neurological disability.
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 12, 2022 Category: Neurosurgery Authors: Grundmann, A., Hardwick, M., Wu, C.-H., Semple, M., Böhning, D., Pett, S., Michael, B., Thomas, R., Galea, I. Tags: Parallel Session 4: COVID Wed 18 May, 1445 - 1600 3 Source Type: research

Aseptic meningitis in Fabry disease due to a novel GLA variant: an expanded phenotype?
ConclusionWe described aseptic meningitis in a family with a novelGLA variant. Meningitis might be a common phenomenon in FD and not a particularity of this variant. Understanding the mechanisms underlying meningitis and its association with cerebrovascular events may lead to a new paradigm of treatment for stroke in these patients. Further prospective studies with CSF collection in patients with FD and recurrent headache could help to elucidate this question.
Source: Neurological Sciences - September 12, 2022 Category: Neurology Source Type: research

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