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Condition: Metabolic Syndrome
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Total 657 results found since Jan 2013.

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
AbstractIschemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, d...
Source: Translational Stroke Research - October 24, 2022 Category: Neurology Source Type: research

Is Metabolic Syndrome Associated with the Risk of Recurrent Stroke: A Meta-Analysis of Cohort Studies
The association between metabolic syndrome (MetS) and recurrence of stroke remains unknown. We summarized the evidence by a meta-analysis of prospective cohort studies.
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2017 Category: Neurology Authors: Xuelong Li, Xianliang Li, Fang Fang, Xian Fu, Hualiang Lin, Qingchun Gao Tags: Review Article Source Type: research

High triglyceride is an independent predictor of high on-treatment platelet reactivity in ischemic stroke patients
In this study, we attempted to evaluate the association between TG and high on-treatment platelet reactivity (HTPR) in IS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2022 Category: Neurology Authors: Haoxuan Chen, Yibo Zhan, Zhenzhen Lou, Hui Mao, Changlin Zhang, Xiaojun Li, Guixian Chen, Huiying Ouyang, Zhiping Huang, Longlong Wen, Haoyou Xu, Zequan Zheng, Yuanqi Zhao, Min Zhao Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

How People With Diabetes Can Lower Stroke Risk
After spending nearly two decades trying to manage her Type 2 diabetes, Agnes Czuchlewski landed in the emergency room in 2015, with news that she’d just experienced a heart attack. She also learned that she had metabolic syndrome, a cluster of conditions that includes diabetes but also brings higher risk of heart disease and stroke. “Because I needed to lose quite a bit of weight when I was first diagnosed, I was focused on the number I saw on the scale, and then on my blood-sugar numbers,” recalls Czuchlewski, 68, who lives in New York City. “I didn’t realize other numbers came into play, li...
Source: TIME: Health - November 10, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized Disease healthscienceclimate Source Type: news

Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic stroke.
Authors: Lucke-Wold BP, Turner RC, Lucke-Wold AN, Rosen CL, Huber JD Abstract Ischemic stroke represents a leading cause of morbidity and mortality in the developed world. This disabling and sometimes fatal event puts an ever increasing burden on the family members and medical professionals who care for stroke victims. Preclinical ischemic stroke research has predominantly utilized young adult, healthy animals, a clear discrepancy when considering the clinical population affected by stroke. A broad spectrum of risk factors such as age, obesity, diabetes, and hypertension has been associated with an increased stroke...
Source: The Yale Journal of Biology and Medicine - November 26, 2014 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke.
Abstract Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post-stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, larg...
Source: Cell Research - November 23, 2016 Category: Cytology Authors: Spychala MS, Honarpisheh P, McCullough LD Tags: J Neurosci Res Source Type: research

Serum fatty acid binding protein 4 is positively associated with early stroke recurrence in nondiabetic ischemic stroke.
This study included the 206 acute ischemic stroke patients hospitalized in our institution. Stroke recurrence events were assessed at the 3-month follow-up. The median of FABP level was 22.6 (IQR, 17.9-31.6) ng/mL in patients with stroke recurrence (N=36), which was higher than in patients without stroke recurrence [16.9 (IQR, 11.8-21.4) ng/mL] (P<0.001). As a continuous variable, the unadjusted and adjusted risk of stroke recurrence would be increased by 12% (OR=1.12 [95% CI 1.06-1.17], P<0.001) and 8% (1.08 [1.02-1.14], P=0.006) for every 1 ng/ml increment of FABP4. The Area under the curve (AUC) of serum FABP4 and...
Source: Aging - April 8, 2019 Category: Biomedical Science Authors: Li B, Wu J, Jiang P, Li M, Liu Q, Cao Y, Wang S Tags: Aging (Albany NY) Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke
Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke‐related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post‐stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, largely due to a s...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Monica S. Spychala, Pedram Honarpisheh, Louise D. McCullough Tags: Review Source Type: research

Hypertension and Diabetes Mellitus as a Predictive Risk Factors for Stroke
Conclusion after summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - March 19, 2018 Category: Endocrinology Source Type: research

Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome
Conclusions: Stroke subjects with acute ischemic stroke and metabolic syndrome showed a higher degree of immuno-inflammatory and arterial stiffness indexes possibly due to metabolic background of these types of patients that trigger a more intense immune-inflammatory activation irrespective of stroke subtype, whereas being related to stroke subtype in subjects without metabolic syndrome.
Source: Epidemiologic Perspectives and Innovations - February 27, 2014 Category: Epidemiology Authors: Antonino TuttolomondoRosaria PecoraroDomenico Di RaimondoRiccardo Di SciaccaBaldassare CaninoValentina ArnaoCarmelo ButtàVittoriano Della CorteCarlo MaidaGiuseppe LicataAntonio Pinto Source Type: research

Metabolic Syndrome and Ischemic Stroke Risk by Sex: Meta-analysis (I12-2B)
CONCLUSIONS: The metabolic syndrome is prevalent, and a significant risk factor for ischemic stroke with differential effects by sex. Women with metabolic syndrome had a near 2 folds higher stroke risk than men with metabolic syndrome. Future studies are needed to elucidate the mechanism by which the metabolic syndrome exerts higher stroke burden on women.Disclosure: Dr. Lin has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Saposnik, G., Shi, Q., Towfighi, A. Tags: Obesity and Neurological Disorders Data Blitz Presentations Source Type: research

Metabolic Syndrome and Ischemic Stroke Risk by Sex: Meta-analysis (P1.004)
CONCLUSIONS: The metabolic syndrome is prevalent, and a significant risk factor for ischemic stroke with differential effects by sex. Women with metabolic syndrome had a near 2 folds higher stroke risk than men with metabolic syndrome. Future studies are needed to elucidate the mechanism by which the metabolic syndrome exerts higher stroke burden on women.Disclosure: Dr. Lin has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Saposnik, G., Shi, Q., Towfighi, A. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

Correlation between CH2DS2-VASc Score and Serum Leptin Levels in Cardioembolic Stroke Patients: The Impact of Metabolic Syndrome.
Conclusion: This pilot study revealed that leptin could be a potential biomarker for risk stratification of cardioembolic stroke in MetS patients and that heterogeneity of stroke subtypes should be considered for more refined and precise clinical stroke studies. PMID: 29225622 [PubMed]
Source: International Journal of Endocrinology - December 13, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hypertension and diabetes mellitus as a predictive risk factors for stroke
Conclusionafter summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 23, 2018 Category: Endocrinology Source Type: research