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Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

A study of the correlation between stroke and gut microbiota over the last 20years: a bibliometric analysis
ConclusionFindings suggest that in the next 10 years, the number of publications produced annually may increase significantly. Future research trends tend to concentrate on the mechanisms of stroke and gut microbiota, with the inflammation and immunological mechanisms, TMAO, and fecal transplantation as hotspots. And the relationship between these mechanisms and a particular cardiovascular illness may also be a future research trend.
Source: Frontiers in Microbiology - June 7, 2023 Category: Microbiology Source Type: research

Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICAS≥70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICAS≥70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results. Introduction Internal carotid artery stenosis (ICAS) causes around one-fifth of ischemic cerebrovascular stroke and has the highest risk of early stroke recurrence...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

Innovations, new strategies and surprising twists in Neurology: captured in new journal Neurological Research and Practice
What are the current hot topics in neurology, what do you anticipate will be the challenges and trends in the future within the field? Neurology is such a rapidly moving field that it is impossible to anticipate what the new trends will be. We were frequently proven wrong with our predictions in the past, while completely unexpected developments happened and new avenues were opened. One thing however is for sure: There will be numerous innovations, new strategies, surprising twists and turns, and within the new journal Neurological Research and Practice we try to capture some of them. What are your research interests and w...
Source: BioMed Central Blog - October 1, 2018 Category: General Medicine Authors: Victoria Hentschke Tags: Biology Medicine Open Access Publishing Neurological Research and Practice Source Type: blogs

Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
Conclusion: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. https://doi.org/10.1289/EHP424 Received: 17 December 2015 Revised: 12 August 2016 Accepted: 30 August 2016 Published: 10 October 2017 Address correspondence to V. Stone, School of Life Sciences, Heriot-Watt University, Edinburgh, UK. Telephone: +44 131 451 3460. Email: v.stone@hw.ac.uk V.S. currently receives grant funding from Byk Altana and from The European Ceramic Fibre Industry Association (ECFIA). In the past, V.S. has received funding from Unilever and GlaxoSmithKline....
Source: EHP Research - October 10, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

The 2017 hormone therapy position statement of The North American Menopause Society
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence. The Panel's recommendations were reviewed and approved by...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia Neuroscience
Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme. Mutations in and aberrant function of UCHL1 have been linked to many neurological disorders. UCHL1 activity protects neurons from hypoxic injury, and binding of stroke-induced reactive lipid species to the cysteine 152 (C152) of UCHL1 unfolds the protein and...
Source: Proceedings of the National Academy of Sciences - March 4, 2019 Category: Science Authors: Hao Liu, Nadya Povysheva, Marie E. Rose, Zhiping Mi, Joseph S. Banton, Wenȷin Li, Fenghua Chen, Daniel P. Reay, German Barrionuevo, Feng Zhang, Steven H. Graham Tags: PNAS Plus Source Type: research