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Total 1466 results found since Jan 2013.

Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke
ConclusionsIn patients with hemorrhagic stroke, nicardipine appeared to have similar efficacy as clevidipine in SBP reduction, with a more likely reduction of rebound hypertension and drug cost. This retrospective study was underpowered, which may limit these implications. Further prospective studies are warranted to confirm these results.
Source: Neurocritical Care - December 13, 2021 Category: Neurology Source Type: research

Pregnancy and stroke risk in women
Neurobiol Dis. 2022 Apr 24:105735. doi: 10.1016/j.nbd.2022.105735. Online ahead of print.ABSTRACTStroke associated with pregnancy and post-partum occurs in about 30 per 100,000 deliveries, and includes subtypes of ischemic and hemorrhagic stroke as well as cerebral venous sinus thrombosis (CVST). There are a wide variety of underlying causes and risk factors, some that are common to both pregnant and non-pregnant women, and others that are unique to pregnancy. Although some of the strokes that occur may be a direct result of the pregnancy itself, such as hypertensive disorders of pregnancy, others could be anticipated or p...
Source: Neurobiology of Disease - April 27, 2022 Category: Neurology Authors: Constance Katsafanas Cheryl Bushnell Source Type: research

Systemic thrombolysis for stroke in pregnancy
Pregnancy is an exclusion criterion for all clinical trials that validate alteplase in acute stroke, so our knowledge about its use in this condition is relative only to case reports and case series. Herein, we report the successful use of intravenous recombinant tissue-type plasminogen activator (rt-PA) in pregnant women with acute stroke. The patient was a 28-year-old who was 16 weeks pregnant. She presented to our hospital 1 hour after a sudden onset of mothor aphasia, hemiparesis, and hypoesthesia on the right side due to incipient ischemia in the left cerebral hemisphere resulting from ipsilateral middle cerebral arte...
Source: The American Journal of Emergency Medicine - August 6, 2012 Category: Emergency Medicine Authors: Rossana Tassi, Maurizio Acampa, Giovanna Marotta, Samuele Cioni, Francesca Guideri, Simone Rossi, Alfonso Cerase, Giuseppe Martini Tags: Case Reports Source Type: research

Risk of future stroke increased by hypertension during pregnancy
High blood pressure during pregnancy could dramatically raise a woman's lifetime risk of stroke, according to a study presented at the Canadian Stroke Congress. "We've found that women who had high blood pressure during pregnancy could be at higher risk of stroke, particularly if they had pre-eclampsia, which is a more severe form of high blood pressure," says Dr. Aravind Ganesh, a neurology resident at the University of Calgary. "The elevated risk of stroke could be as high as 40 per cent." Dr. Ganesh, along with Neha Sarna (medical student), Dr...
Source: Health News from Medical News Today - October 22, 2013 Category: Consumer Health News Tags: Hypertension Source Type: news

Pregnancy-associated Intracranial Hemorrhage: Results of a Survey of Neurosurgical Institutes across Japan
Conclusion: Pregnancy-associated hemorrhagic strokes frequently concealed baseline CVDs, especially when they occurred before the 32nd week of gestation. AVMs were the predominant bleeding source. For appropriate treatment, therefore, close examination for cerebral vascular lesions is essential when a pregnancy-associated hemorrhagic stroke is encountered.
Source: Journal of Stroke and Cerebrovascular Diseases - November 18, 2013 Category: Neurology Authors: Jun C. Takahashi, Koji Iihara, Akira Ishii, Eiju Watanabe, Tomoaki Ikeda, Susumu Miyamoto Tags: Original Articles Source Type: research

Comment Sex disparity in the risk of diabetes-associated stroke
In the general population, stroke is more prevalent in men than in women. Men also have a higher age-specific stroke incidence than women, except for women aged 35–44 years and those older than 85 years. Factors such as pregnancy and the use of oral contraceptives are believed to contribute to the increased risk of stroke in women in their mid-30s to mid-40s, and their relative longevity contributes to the higher risk of stroke in older women.
Source: LANCET - June 6, 2014 Category: Journals (General) Authors: Linong Ji Tags: Comment Source Type: research

The risk of fatal stroke in Finnish postmenopausal hormone therapy users before and after the Women's Health Initiative: A cohort study
Stroke is the third most common cause of death and the most common cause of prolonged disability in women worldwide[1]. Therefore, the American Heart and Stroke Association recently published strict new guidelines for the prevention of stroke in women [2]. These guidelines acknowledge a number of female gender-related risk factors for stroke, such as migraine, pregnancy, pre-eclampsia, atrial fibrillation, obesity, metabolic syndrome, living alone -status and consequent delay in thrombolysis, and longevity.
Source: Maturitas - April 13, 2015 Category: Primary Care Authors: Pauliina Tuomikoski, Heli Lyytinen, Pasi Korhonen, Fabian Hoti, Pia Vattulainen, Mika Gissler, Olavi Ylikorkala, Tomi S. Mikkola Source Type: research

Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring.
Abstract The maternal system is challenged with many physiological changes throughout pregnancy to prepare the body to meet the metabolic needs of the fetus and for delivery. Many pregnancies, however, are faced with pathological stressors or complications that significantly impact maternal health. A shift in this paradigm is now beginning to investigate the implication of pregnancy complications on the fetus and their continued influence on offspring disease risk into adulthood. In this investigation, we sought to determine whether maternal hypertension during pregnancy alters the cerebral response of adult offsp...
Source: Molecular and Cellular Biochemistry - July 14, 2015 Category: Biochemistry Authors: Ventura NM, Jin AY, Tse MY, Peterson NT, Andrew RD, Mewburn JD, Pang SC Tags: Mol Cell Biochem Source Type: research

Acute ischemic stroke and abnormal blood hemoglobin concentration
ConclusionsOur results suggest that an elevated HGB on the initial admission is associated with more severe strokes, greater disability at discharge, and higher 30‐day mortality after AIS. A low HGB on admission is associated with longer stay in the acute care hospital.
Source: Acta Neurologica Scandinavica - October 21, 2015 Category: Neurology Authors: J. C. Furlan, J. Fang, F. L. Silver Tags: Original Article Source Type: research

Treatment Patterns and Short-Term Outcomes in Ischemic Stroke in Pregnancy or Postpartum
Stroke is a rare but devastating event during pregnancy, occurring in 34/100,000 deliveries, and obstetricians are often the first providers to be contacted by symptomatic patients. At least half of pregnancy-related strokes are likely to be of the ischemic stroke subtype. Most pregnant or newly postpartum women with ischemic stroke do not receive acute stroke reperfusion therapy although this is the recommended treatment for adults. Little is known about these therapies in pregnant or postpartum women as pregnancy has been an exclusion criteria for all reperfusion trials.
Source: American Journal of Obstetrics and Gynecology - December 17, 2015 Category: OBGYN Authors: Lisa R. Leffert, Caitlin R. Clancy, Brian T. Bateman, Margueritte Cox, Phillip J. Schulte, Eric E. Smith, Gregg C. Fonarow, Elena V. Kuklina, Mary G. George, Lee H. Schwamm Source Type: research

Pregnancy related stroke in the setting of homozygous type-II HBS antithrombin deficiency
Stroke is defined as a focal or global disturbance of cerebral function lasting over 24h; resulting from disruption of blood supply [1]. Stroke during pregnancy is fortunately a rare event, but it can have severe consequences, such as long-term disability or death, with 9.5% of all maternal deaths being related to stroke [2]. The overall risk of pregnancy-related stroke was 34.2 (95% CI 33.3–35.1) per 100000 deliveries in the USA, with 48% occurring postpartum, 41% at the time of delivery and 11% antepartum [3].
Source: Thrombosis Research - January 27, 2016 Category: Hematology Authors: Mirjana Kovac, Gorana Mitic, Zeljko Mikovic, Vesna Mandic, Valentina Djordjevic, Laszlo Muszbek, Zsuzsanna Bereczky Tags: Correspondence Source Type: research

Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period
Stroke, which is a rare but devastating event during pregnancy, occurs in 34 of every 100,000 deliveries; obstetricians are often the first providers to be contacted by symptomatic patients. At least one-half of pregnancy-related strokes are likely to be of the ischemic stroke subtype. Most pregnant or newly postpartum women with ischemic stroke do not receive acute stroke reperfusion therapy, although this is the recommended treatment for adults. Little is known about these therapies in pregnant or postpartum women because pregnancy has been an exclusion criterion for all reperfusion trials.
Source: American Journal of Obstetrics and Gynecology - December 17, 2015 Category: OBGYN Authors: Lisa R. Leffert, Caitlin R. Clancy, Brian T. Bateman, Margueritte Cox, Phillip J. Schulte, Eric E. Smith, Gregg C. Fonarow, Elena V. Kuklina, Mary G. George, Lee H. Schwamm Tags: Original Research Source Type: research

Pregnancy and acute ischemic stroke.
Abstract Pregnancy-related ischemic strokes play an important role in both maternal and fetal morbidity and mortality. Changes in hemostaseology and hemodynamics as well as risk factors related to or independent from pregnancy contribute to the increased stroke-risk during gestation and the puerperium. Potential teratogenic effects make diagnostics, acute therapy and prevention challenging. Because randomized, controlled trials are not available, a multicenter registry of patients with gestational stroke would be desirable. Until definite guidelines emerge, management of acute ischemic stroke during pregnancy rema...
Source: Orvosi Hetilap - April 30, 2016 Category: Journals (General) Authors: Ifj Bereczki D Tags: Orv Hetil Source Type: research

Mechanical thrombectomy for acute ischemic stroke in pregnancy using the penumbra system
Sanjith Aaron, NK Shyamkumar, Sunithi Alexander, P Suresh Babu, AT Prabhakar, Vinu Moses, TV Murthy, Mathew AlexanderAnnals of Indian Academy of Neurology 2016 19(2):261-263Even though intravenous thrombolysis with tissue plasminogen activator (IV tPA) is the standard of care in acute ischemic stroke, its use in pregnancy is not clearly defined. Mechanical thrombectomy devices can be an option; however, literature on the use of such mechanical devices in stroke in pregnancy is lacking. Here we describe two cases that developed acute embolic stroke during pregnancy who were successfully treated by mechanical clot retrieval ...
Source: Annals of Indian Academy of Neurology - May 11, 2016 Category: Neurology Authors: Sanjith AaronNK ShyamkumarSunithi AlexanderP Suresh BabuAT PrabhakarVinu MosesTV MurthyMathew Alexander Source Type: research