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Condition: Stroke
Procedure: Perfusion

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Total 4550 results found since Jan 2013.

Combined PET/MRI: Multimodality insights into acute stroke hemodynamics
A 61-year-old man underwent simultaneous PET/MRI 5.5 hours after sudden onset of aphasia (NIH Stroke Scale 4), which revealed a diffusion/perfusion mismatch of different extents as measured with pulsed arterial spin-labeling MRI (59 mL), perfusion-weighted MRI (27 mL), and [15O]H2O-PET (36 mL) (figure). Due to spontaneous recanalization, the penumbra tissue did not progress towards infarction. This demonstrates that the outcome of critically hypoperfused stroke brain tissue may be favorable even without sufficient collateral flow and without therapeutic intervention.1 Here, PET/MRI offers the chance to cross-evaluate MRI-b...
Source: Neurology - May 15, 2016 Category: Neurology Authors: Werner, P., Saur, D., Mildner, T., Moller, H., Classen, J., Sabri, O., Hoffmann, K.-T., Barthel, H. Tags: MRI, PET, DWI, All Cerebrovascular disease/Stroke NEUROIMAGES Source Type: research

Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy Clinical Sciences
Conclusions— Our study demonstrates best accuracy and approximation between the results of a fully automated software (RAPID) and FIV, especially in early and fully recanalized patients. Furthermore, this software package overestimated the FIV to a significantly lower degree and estimated a malignant mismatch profile less often than other software.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Austein, F., Riedel, C., Kerby, T., Meyne, J., Binder, A., Lindner, T., Huhndorf, M., Wodarg, F., Jansen, O. Tags: Computerized Tomography (CT), Ischemic Stroke Clinical Sciences Source Type: research

Risk of acute kidney injury associated with neuroimaging obtained during triage and treatment of patients with acute ischemic stroke symptoms
Conclusions This study provides preliminary evidence of the safety and feasibility of obtaining CTSS with additional DSA imaging, whether for diagnosis or intervention, to identify possible acute ischemic stroke.
Source: Journal of NeuroInterventional Surgery - November 14, 2016 Category: Neurosurgery Authors: Hall, S. L., Munich, S. A., Cress, M. C., Rangel-Castilla, L., Levy, E. I., Snyder, K. V., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

Relationship Between Changes in the Temporal Dynamics of the Blood-Oxygen-Level-Dependent Signal and Hypoperfusion in Acute Ischemic Stroke Clinical Sciences
Conclusions—BOLD delay is related to macrovascular delay and microvascular hypoperfusion, can identify severely hypoperfused tissue in acute stroke, and is a promising alternative to gadolinium contrast agent–based perfusion assessment in acute stroke.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00715533 and NCT02077582.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Ahmed A. Khalil, Ann-Christin Ostwaldt, Till Nierhaus, Ramanan Ganeshan, Heinrich J. Audebert, Kersten Villringer, Arno Villringer, Jochen B. Fiebach Tags: Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Imaging (MRI) Original Contributions Source Type: research

Neurons Over Nephrons Clinical Sciences
Background and Purpose—Because of the perceived risk of contrast-induced acute kidney injury (AKI), many centers require pre-imaging serum creatinine levels, potentially delaying care. We performed a systematic review and meta-analysis evaluating AKI rates in patients with acute ischemic stroke receiving computed tomographic angiography (CTA) and computed tomographic perfusion (CTP).Methods—We searched MEDLINE, EMBASE, and the Web of Science through December 2016 for studies reporting on AKI in patients with acute ischemic stroke receiving CTA/CTP. Using a random-effects model, estimates were pooled across studies. Out...
Source: Stroke - June 26, 2017 Category: Neurology Authors: Waleed Brinjikji, Andrew M. Demchuk, Mohammad H. Murad, Alejandro A. Rabinstein, Robert J. McDonald, Jennifer S. McDonald, David F. Kallmes Tags: Imaging, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke
Conclusions: Global SVD burden is associated with increased BBB leakage in both acutely ischemic and nonischemic area. Our results support that SVD score has construct validity, and confirm a relation between SVD and BBB disruption also in patients with acute stroke.
Source: Neurology - November 20, 2017 Category: Neurology Authors: Arba, F., Leigh, R., Inzitari, D., Warach, S. J., Luby, M., Lees, K. R., On behalf of the STIR/VISTA Imaging Collaboration Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

White Matter Integrity and Early Outcomes After Acute Ischemic Stroke
AbstractChronic white matter structural injury is a risk factor for poor long-term outcomes after acute ischemic stroke (AIS). However, it is unclear how white matter structural injury predisposes to poor outcomes after AIS. To explore this question, in 42 AIS patients with moderate to severe white matter hyperintensity (WMH) burden, we characterized WMH and normal-appearing white matter (NAWM) diffusivity anisotropy metrics in the hemisphere contralateral to acute ischemia in relation to ischemic tissue and early functional outcomes. All patients underwent brain MRI with dynamic susceptibility contrast perfusion and diffu...
Source: Translational Stroke Research - January 28, 2019 Category: Neurology Source Type: research

The Yield of Multimodal Computed Tomography among Emergency Department Patients with Suspected Large Vessel Occlusion Stroke
Objectives: Endovascular therapy (EVT) improves outcomes for appropriately selected acute ischemic stroke patients. Guidelines suggest rapid acquisition of noninvasive vascular imaging to screen suspected ischemic stroke patients for large vessel occlusion (LVO) and candidacy for EVT. We sought to quantify the yield of an LVO stroke screening process in an undifferentiated emergency department (ED) suspected stroke population as well as identify predictors of successful EVT. Methods: We identified a cohort of consecutive ED patients who received CT angiography and brain perfusion (CTA/P) imaging to determine candidacy for EVT during 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2019 Category: Neurology Authors: Yalda Serena Dastmalchi, J. Adam Oostema Source Type: research

Image level detection of large vessel occlusion on 4D-CTA perfusion data using deep learning in acute stroke
Acute ischemic stroke (AIS) secondary to LVOs represent approximately 30-40% of all stroke cases and are associated with disproportionately higher morbidity and mortality.1, 2 The importance of endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS) has been well established in multiple randomized controlled trials for patients in both early and late stroke windows.3-6 A critical aspect of the patient triage is the accurate and timely detection of underlying large vessel occlusion (LVO).
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2022 Category: Neurology Authors: Girish Bathla, Dhruba Durjoy, Sarv Priya, Edgar Samaniego, Colin P. Derdeyn Source Type: research

Interobserver Agreement of ASPECT Score Distribution for Noncontrast CT, CT Angiography, and CT Perfusion in Acute Stroke Brief Reports
Conclusions— CTP-CBV demonstrates the highest interobserver agreement for individual ASPECTS regions.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Finlayson, O., John, V., Yeung, R., Dowlatshahi, D., Howard, P., Zhang, L., Swartz, R., Aviv, R. I. Tags: Acute Cerebral Infarction, Angiography, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Timing-Invariant Imaging of Collateral Vessels in Acute Ischemic Stroke Clinical Sciences
Conclusions— Collateral vessels may not always be visible on standard single time-frame CTA because of delayed contrast arrival. Future prognostic studies in acute stroke should consider delay-insensitive techniques, such as TI-CTA, instead of standard single time-frame imaging, such as standard CTA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Smit, E. J., Vonken, E.-j., van Seeters, T., Dankbaar, J. W., van der Schaaf, I. C., Kappelle, L. J., van Ginneken, B., Velthuis, B. K., Prokop, M. Tags: Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Arterial Spin-Labeled Perfusion Imaging to Predict Mismatch in Acute Ischemic Stroke Brief Reports
Conclusions— In acute ischemic stroke, PWI lesions based on ASL threshold of <20 mL/100 g per minute can provide a reliable estimate of mismatch in correspondence at MTT threshold of >10 s.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Niibo, T., Ohta, H., Yonenaga, K., Ikushima, I., Miyata, S., Takeshima, H. Tags: Acute Cerebral Infarction Brief Reports Source Type: research

Meta-analyses Indicate Associations between Neuroendocrine Activation, Deactivation in Neurotrophic and Neuroimaging Markers in Depression after Stroke
Conclusions: Cortisol-lowering therapies and those that increase blood flow and neurotrophic factors represent promising novel therapeutics for depression subtypes and may reduce the risk of depression in stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - November 12, 2012 Category: Neurology Authors: Kate Noonan, Leeanne M. Carey, Sheila G. Crewther Tags: Original Articles Source Type: research

A score based on age and DWI volume predicts poor outcome following endovascular treatment for acute ischemic stroke
ConclusionsThe Stanford Age and Diffusion‐Weighted Imaging and Houston Intra‐Arterial Therapy scores can be used to predict poor functional outcome following endovascular therapy with good accuracy. However, these scores do not predict the clinical response to reperfusion. This limits their utility as tools to select patients for acute stroke interventions.
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: John T. P. Liggins, Albert J. Yoo, Nishant K. Mishra, Hayley M. Wheeler, Matus Straka, Thabele M. Leslie‐Mazwi, Zeshan A. Chaudhry, Stephanie Kemp, Michael Mlynash, Roland Bammer, Gregory W. Albers, Maarten G. Lansberg, Tags: Research Source Type: research

Arterial Spin Labeling Versus Bolus-Tracking Perfusion in Hyperacute Stroke Clinical Sciences
Conclusions— ASL-DWI mismatch shows potential to identify salvageable tissue in hyperacute stroke.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Bivard, A., Krishnamurthy, V., Stanwell, P., Levi, C., Spratt, N. J., Davis, S., Parsons, M. Tags: CT and MRI Clinical Sciences Source Type: research