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Condition: Stroke
Procedure: Perfusion

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Total 4550 results found since Jan 2013.

Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke Clinical Sciences
Conclusions—Compared with target mismatch patients, those with the malignant profile experience faster infarct growth and a steeper decline in the odds of functional independence, with longer delays between baseline imaging and reperfusion. However, this does not exclude the possibility of treatment benefit in patients with a malignant profile.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Jenny P. Tsai, Michael Mlynash, Soren Christensen, Stephanie Kemp, Sun Kim, Nishant K. Mishra, Christian Federau, Raul G. Nogueira, Tudor G. Jovin, Thomas G. Devlin, Naveed Akhtar, Dileep R. Yavagal, Roland Bammer, Matus Straka, Gregory Zaharchuk, Michael Tags: Revascularization, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

Association Between CT Angiogram Collaterals and CT Perfusion in the Interventional Management of Stroke III Trial Brief Reports
Conclusion— Better collaterals were associated with smaller ischemic core and higher mismatch in the IMS III trial. Collateral assessment and perfusion imaging identify the same biological construct about ischemic tissue sustenance.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Vagal, A., Menon, B. K., Foster, L. D., Livorine, A., Yeatts, S. D., Qazi, E., dEsterre, C., Shi, J., Demchuk, A. M., Hill, M. D., Liebeskind, D. S., Tomsick, T., Goyal, M. Tags: Computerized Tomography (CT), Imaging, Ischemic Stroke Brief Reports Source Type: research

Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia Brief Reports
Conclusions— This study demonstrates that diffuse, mild BBB disruption in the acutely ischemic human brain is reversible with reperfusion. This study also confirms prior findings that focal severe BBB disruption confers an increased risk of hemorrhagic transformation in patients treated with intravenous tissue-type plasminogen activator.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Simpkins, A. N., Dias, C., Leigh, R., on behalf of the National Institutes of Health Natural History of Stroke Investigators, Benson, Hsia, Latour, Luby, Lynch, Merino, Nadareishvili, Warach Tags: Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes Clinical Sciences
Background and Purpose—The minimal scan duration needed to obtain reliable lesion volumes with computed tomographic perfusion (CTP) has not been well established in the literature.Methods—We retrospectively assessed the impact of gradual truncation of the scan duration on acute ischemic lesion volume measurements. For each scan, we identified its optimal scan time, defined as the shortest scan duration that yields measurements of the ischemic lesion volumes similar to those obtained with longer scanning, and the relative height of the fitted venous output function at its optimal scan time.Results—We analyzed 70 compu...
Source: Stroke - November 27, 2016 Category: Neurology Authors: Aimen S. Kasasbeh, Soren Christensen, Matus Straka, Nishant Mishra, Michael Mlynash, Roland Bammer, Gregory W. Albers, Maarten G. Lansberg Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke Clinical Sciences
This study aimed to assess how the ischemic core measured by perfusion computed tomography (CTP) was affected by the delay and dispersion effect.Methods—Ischemic stroke patients having CTP performed within 6 hours of onset were included. The CTP data were processed twice, generating standard cerebral blood flow (sCBF) and delay- and dispersion-corrected CBF (ddCBF), respectively. Ischemic core measured by the sCBF and ddCBF was then compared at the relative threshold
Source: Stroke - March 26, 2018 Category: Neurology Authors: Longting Lin, Andrew Bivard, Timothy Kleinig, Neil J. Spratt, Christopher R. Levi, Qing Yang, Mark W. Parsons Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Prediction of Tissue Outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep Learning Clinical Sciences
Background and Purpose—Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume.Methods—Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep) to predict final imaging outcome. A total of 222 patients were included, of which 187 were treated with...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Treatment, Quality and Outcomes, Statements and Guidelines, Ischemic Stroke Original Contributions Source Type: research

Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation
ConclusionAtrial fibrillation is associated with greater volumes of more severe baseline hypoperfusion, leading to higher infarct growth, more frequent severe hemorrhagic transformation and worse stroke outcomes.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Hans T. H. Tu, Bruce C. V. Campbell, Soren Christensen, Patricia M. Desmond, Deidre A. De Silva, Mark W. Parsons, Leonid Churilov, Maarten G. Lansberg, Michael Mlynash, Jean‐Marc Olivot, Matus Straka, Roland Bammer, Gregory W. Albers, Geoffrey A. Donnan Tags: Research Source Type: research

Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry
There are limited data on the utilization of diagnostics and the variation of treatments at the national level in acute stroke care. Clinical Research Center for Stroke – 5th division stroke registry aimed to describe stroke statistics and quality of care in Korea and to implement quality indicators. Clinical Research Center for Stroke – 5th division registry was established in April 2008 and covers pretreatment demographics, medical and stroke severity measures, diagnostic evaluation, hyperacute revascularization, in‐hospital management, discharge disposition, quality indicators, and long‐term functional outcomes....
Source: International Journal of Stroke - November 21, 2013 Category: Neurology Authors: Beom Joon Kim, Moon‐Ku Han, Tai Hwan Park, Sang‐Soon Park, Kyung Bok Lee, Byung‐Chul Lee, Kyung‐Ho Yu, Jae Kwan Cha, Dae‐Hyun Kim, Jun Lee, Soo Joo Lee, Youngchai Ko, Jong‐Moo Park, Kyusik Kang, Yong‐Jin Cho, Keun‐Sik Hong, Ki‐Hyun Cho, Tags: Panorama Source Type: research

National Institutes of Health Stroke Scale score is an unreliable predictor of perfusion deficits in acute stroke
ConclusionsAlthough higher National Institutes of Health Stroke Scale scores are predictive of perfusion deficits, many patients with no clinically detectable signs have persisting cerebral blood flow changes. A National Institutes of Health Stroke Scale score threshold should therefore not be used to select patients for perfusion‐weighted magnetic resonance imaging. Perfusion‐weighted magnetic resonance imaging should be considered in all patients presenting with acute focal neurological deficits, even if these deficits are transient.
Source: International Journal of Stroke - April 6, 2015 Category: Neurology Authors: Victor Choi, Mahesh Kate, Jayme C. Kosior, Brian Buck, Trevor Steve, Rebecca McCourt, Thomas Jeerakathil, Ashfaq Shuaib, Derek Emery, Ken Butcher Tags: Research Source Type: research

Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, Update 2015
The 2015 update of the Canadian Stroke Best Practice Recommendations Hyperacute Stroke Care guideline highlights key elements involved in the initial assessment, stabilization, and treatment of patients with transient ischemic attack (TIA), ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and acute venous sinus thrombosis. The most notable change in this 5th edition is the addition of new recommendations for the use of endovascular therapy for patients with acute ischemic stroke and proximal intracranial arterial occlusion. This includes an overview of the infrastructure and resources required ...
Source: International Journal of Stroke - July 6, 2015 Category: Neurology Authors: Leanne K. Casaubon, Jean‐Martin Boulanger, Dylan Blacquiere, Scott Boucher, Kyla Brown, Tom Goddard, Jacqueline Gordon, Myles Horton, Jeffrey Lalonde, Christian LaRivière, Pascale Lavoie, Paul Leslie, Jeanne McNeill, Bijoy K. Menon, Brian Moses, Melani Tags: Guidelines Source Type: research

Dehydration Is Associated with More Severe Hemispatial Neglect after Stroke (S02.004)
CONCLUSIONS: Patients who are dehydrated at the time of presentation with stroke have more severe stroke symptoms, independent of stroke severity. This represents an opportunity to evaluate our hydration practices in patients with varying degrees of cardiac dysfunction during the acute stroke period in order to prescribe more precise fluid resuscitation algorithms. Future clinical trials designed to evaluate fluid resuscitation practices at the time of ischemic stroke are needed.Disclosure: Dr. Bahouth has nothing to disclose. Dr. Bahrainwala has nothing to disclose. Dr. Hillis has received personal compensation in an edit...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bahouth, M., Bahrainwala, Z., Hillis, A., Gottesman, R. Tags: S02 Acute Stroke Therapy Source Type: research

Impaired perfusion modifies the relationship between blood pressure and stroke risk in major cerebral artery disease
Conclusions Impaired perfusion modified the relationship between blood pressure and stroke risk, although this study had limitations including the retrospective analysis, the potentially biased sample, the small number of critical events and the fact that BP was measured only as a snapshot in clinic.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Yamauchi, H., Higashi, T., Kagawa, S., Kishibe, Y., Takahashi, M. Tags: Open access, Stroke, Hypertension, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Stroke Lesion Volumes and Outcome Are Not Different in Hemispheric Stroke Side Treated With Intravenous Thrombolysis Based on Magnetic Resonance Imaging Criteria Clinical Sciences
Conclusions— We did not find differences between RHS and left HS with regards to stroke lesions volumes or outcome after thrombolysis. Previously reported hemisphere-related differences in stroke outcome may partly results from imbalances in stroke lesion volume between RHS and left HS.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Golsari, A., Cheng, B., Sobesky, J., Schellinger, P. D., Fiehler, J., Gerloff, C., Thomalla, G. Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window Brief Report
Conclusions—Of all patients with acute ischemic stroke presenting to a single comprehensive stroke center, 1.7% of patients qualified for DAWN clinical trial enrollment with an additional 0.6% to 1% qualifying for the DEFUSE-3 trial. These data predict an increase in thrombectomy utilization with important implications for comprehensive stroke center resource optimization and stroke systems of care.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Ashutosh P. Jadhav, Shashvat M. Desai, Cynthia L. Kenmuir, Marcelo Rocha, Matthew T. Starr, Bradley J. Molyneaux, Bradley A. Gross, Brian T. Jankowitz, Tudor G. Jovin Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Brief Reports Source Type: research

Prognostic Evaluation Based on Cortical Vein Score Difference in Stroke Clinical Sciences
Conclusions— The Prognostic Evaluation based on Cortical vein score difference In Stroke score, a novel measure of venous enhancement on CT angiography, accurately predicts clinical outcomes. Venous features on computed tomography angiography provide additional characterization of collateral perfusion and prognostication in acute ischemic stroke.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Parthasarathy, R., Kate, M., Rempel, J. L., Liebeskind, D. S., Jeerakathil, T., Butcher, K. S., Shuaib, A. Tags: Acute Cerebral Infarction, Brain Circulation and Metabolism, Angiography, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research