Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke

Conclusions: Global SVD burden is associated with increased BBB leakage in both acutely ischemic and nonischemic area. Our results support that SVD score has construct validity, and confirm a relation between SVD and BBB disruption also in patients with acute stroke.
Source: Neurology - Category: Neurology Authors: Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

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Publication date: Available online 14 January 2019Source: Academic RadiologyAuthor(s): Houman Sotoudeh, Asim K. Bag, Michael David BrooksRationale and ObjectivesRegarding the most recent ischemic stroke treatment guideline, perfusion imaging has been recommended up to 24 hours after initial symptoms of brain infarction. Patients with a significant amount of salvageable peri-infarct ischemia and no contraindications benefit from delayed thrombolysis and intra-arterial thrombectomy. This approach causes increasingly more CT perfusion to be done in the subacute phase of ischemic stroke. CT perfusion findings in this “su...
Source: Academic Radiology - Category: Radiology Source Type: research
We present a single-center experience with CTP selection and comparison with CTP trials. Methods: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 or M2) and with admission brain CTP analyzed by RAPID software were included into the analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Abstract OBJECTIVEThe role of CT perfusion (CTP) in the management of patients with acute ischemic stroke (AIS) remains a matter of debate. The primary aim of this study was to evaluate the correlation between the areas of infarction and penumbra on CTP scans and functional outcome in patients with AIS.METHODSThis was a retrospective review of 100 consecutively treated patients with acute anterior circulation ischemic stroke who underwent CT angiography (CTA) and CTP at admission between February 2011 and October 2014. On CTP, the volume of ischemic core and penumbra was measured using the Alberta Stroke Program E...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
We describe the case of a patient with CF, who had a migrainous stroke during an SHM attack. A 32-year-old Caucasian male was diagnosed with CF, with heterozygotic delta F508/unknown CFTR mutation. The patient experiences bouts of coughing sometimes triggering SHM attacks with visual phosphenes, aphasia, right-sided paresthesia, and hemiparesis. He had a 48-hour hemiparesis triggered by a bout of coughing with hemoptysis, loss of consciousness, and severe hypoxia-hypercapnia. MRI demonstrated transient diffusion hyperintensity in the left frontal-parietal-occipital regions resulting in a permanent infarction in the primary...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
AbstractBackgroundLeukoaraiosis (LA) is related to the dysfunction of the microcirculation and results in the impairment of the perfusion state. We investigated the association of LA and poor outcomes after successful recanalization by thrombectomy.MethodsWe retrospectively analyzed 97 patients with anterior large-artery occlusion who underwent thrombectomy and had successful recanalization (modified Treatment in Cerebral Ischemia Scale score 2b or 3). All patients underwent magnetic resonance imaging (MRI). LA was evaluated using fluid-attenuated inversion recovery MRI and graded using the Fazekas scale. Poor functional o...
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusion: In extended time windows, RAPID provides a fast and reliable estimate of salvageable brain tissue to help select patients for endovascular treatment.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Conclusions: In summary, platelet membrane-based nanobubbles for targeting acute ischemic lesions were developed as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics. This biomimetic PNBs theranostic strategy will be valuable for ischemic stroke patients in the future.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
The feasibility of using susceptibility-weighted imaging (SWI) in a clinical setting was assessed for quantifying leptomeningeal collateralization. Eighteen patients with stroke and acute infarction underwent diffusion-weighted imaging, SWI, perfusion-weighted imaging, and magnetic resonance angiography within 3 days after symptom onset. Lesions were evaluated by the Alberta Stroke Program Early CT score (ASPECTS), based on mean transit time, SWI, and cerebral blood volume (CBV). For evaluating ischemic penumbra and leptomeningeal collateralization, the SWI-ASPECTS significantly correlated, respectively, with mean transi...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Rationale: With the development of multi-slice computed tomography (CT) technology, perfusion CT angiography (p-CTA) is now widely used for the diagnosis of acute cerebral infarction. Although p-CTA has the advantage of distinguishing between an ischemic penumbra and an infarct core, more research is needed with respect to its clinical use. Patient concerns: A healthy 36-year-old man experienced sudden dizziness while swimming. His dizziness persisted irrespective of the change in position, and then improved during transport. He had no neurological abnormality when he arrived at the emergency room. Diagnoses: CT pe...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Christian Lucas, Andr é Kemmling, Nassim Bouteldja, Linda F. Aulmann, Amir Madany Mamlouk, Mattias P. Heinrich
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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