Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke

Conclusions: Global SVD burden is associated with increased BBB leakage in both acutely ischemic and nonischemic area. Our results support that SVD score has construct validity, and confirm a relation between SVD and BBB disruption also in patients with acute stroke.
Source: Neurology - Category: Neurology Authors: Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

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CONCLUSIONS: Thrombus permeability assessed on dynamic CTA could be a better predictor of outcome after reperfusion therapy than that assessed on conventional single-phase CTA.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: INTERVENTIONAL Source Type: research
Authors: Cho BH, Cheon K, Lee KY PMID: 30284769 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Conclusions: Non-standard criteria for rtPA eligibility were evident in all three countries and could, in part, explain comparably low use of rtPA. Differences in the use of standard criteria may signify practitioner intolerance for those derived from original efficacy studies that are no longer relevant.Intervent Neurol 2019;8:1 –12
Source: Interventional Neurology - Category: Neurology Source Type: research
Publication date: September 2018Source: Journal of Clinical Neuroscience, Volume 55Author(s): Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Jianjun Lu, Yan Xu, Jinlong Ye, Zuying Kuang, Bo Li, Mengqiu Pan, Wenming Chen, Shuisheng Lu, Ziyang Zhou, Lina Cheng, Honghao WangAbstractTo compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS an...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusion: This randomized study will provide important information about the physiological effects of BP reduction on cerebral perfusion after intravenous thrombolysis in AIS.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Abstract We investigated structural and functional differences in primary and pial collateral circulations in adult normotensive male and female Wistar rats. Male (n=10) and female (n=7) rats were subjected to middle cerebral artery (MCA) occlusion and changes in relative cerebral blood flow (rCBF) in MCA and pial collateral territories were measured by multi-site laser Doppler flowmetry. Rats were then transcardially perfused with a mixture of carbon black and latex, perfusion fixed and imaged to compare primary and pial collateral structure between males (n=4) and females (n=3), including lumen diameters and num...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
Conclusions: In our population, patients with CAO clinically present with severe strokes. Isolated occlusions of the extra- or intracranial segments of the carotid are more frequent than tandem occlusions. Successful recanalization after thrombectomy is achieved in most of the patients, but association with favorable functional outcome is poor. Clinical evolution is similar in patients treated with PMT and BT. Intracranial symptomatic hemorrhage after treatment is associated with higher intrahospital mortality and worse 3 months-mRS. Poor perfusion-CT mismatch, symptomatic hemorrhage, and isolated CAO are independent predi...
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
CONCLUSION: Findings indicate the beneficial effects of HCG and Trolox on the improvement of memory and the number of healthy cells in the hippocampal region. It is worth noting that the amount of apoptosis in the hippocampus was significantly reduced by Trolox, HCG and Carnosic acid. PMID: 30227824 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
Publication date: Available online 15 September 2018Source: Neuroimaging Clinics of North AmericaAuthor(s): Carlos Leiva-Salinas, Bin Jiang, Max Wintermark
Source: Neuroimaging Clinics of North America - Category: Radiology Source Type: research
We present a diagnostic strategy in a pregnant woman with suspect of acute stroke. We perform magnetic resonance with arterial spin labeling sequence, an X-ray and contrast medium safe perfusion technique. Arterial spin labeling can detects collateral vessels in patient with acute ischemic stroke. Demonstrating collateral vessels is relevant for better understanding prognosis and for improving the diagnostic assessment in pregnancy.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
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