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Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke

Conclusions: Global SVD burden is associated with increased BBB leakage in both acutely ischemic and nonischemic area. Our results support that SVD score has construct validity, and confirm a relation between SVD and BBB disruption also in patients with acute stroke.
Source: Neurology - Category: Neurology Authors: Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

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Background and Purpose—Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans.Methods—Patients with suspected TIA underwent acute brain perfusion imaging, and those with acute ischemia were enrolled into a prospective observational study. We collected baseline and 90-day magnetic resonance imaging, including MP-RAGE (high-resolution T1 sequence) and cognitive assessment with the Montreal Cognitive Assessment. Brain morphometry and within pati...
Source: Stroke - Category: Neurology Authors: Tags: Clinical Studies, Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Cognitive Impairment, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Abstract BackgroundWe aimed to determine predictors of focal hypoperfusion on CT Perfusion (CTP) in patients with acute posterior circulation stroke and its association with long‐term outcome. MethodsWe selected patients with posterior circulation stroke from the Acute STroke Registry and Analysis of Lausanne (ASTRAL) who underwent CTP within 24 hours of stroke onset as part of the stroke imaging protocol. Hypoperfusion was defined as an area of visually well demarcated mean‐transit‐time (MTT) prolongation corresponding to an arterial territory on standard reconstruction CTP imaging maps. Areas of hypoperfusion were ...
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
Purpose of review The clinical practice of acute ischemic stroke treatment has undergone a major change over the last 5 years, as multimodal imaging becomes more accessible, and evidence mounts that individualized treatment is possible. Multimodal imaging performed before treatment provides invaluable information to treating clinicians, which includes confirmation of the diagnosis, and provides guidance on the appropriateness and the likely outcome of intravenous or endovascular treatment for individual patients (and their families). However, often health systems struggle to keep pace with science; thus, a one-size fits ...
Source: Current Opinion in Neurology - Category: Neurology Tags: CEREBROVASCULAR DISEASE: Edited by Hugh S. Markus Source Type: research
Conclusion: BBBP predicts HT but does not improve prediction with age and admission NIHSS.Cerebrovasc Dis 2018;45:26 –32
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
Conclusions In both CTP methods, the most prominent difference was found in dMTT. Visually, penumbra was better distinguished by SVD in proximal critical stenosis, whereas was better distinguished by SVD+ in distal critical stenosis. In cases having both ipsilateral critical proximal and distal stenoses, penumbra was noted in SVD but pseudohyperperfusion in SVD+. This finding showed that extraction of contrast delay in the SVD+ method might cause false results in cases of ipsilateral critical proximal and distal stenoses.
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Neuroradiology Source Type: research
Conclusions The optimized IVIM protocol proposed in the current study allows for measurements of cerebral hypoperfusion that might be of great interest for pathologies diagnosis such as ischemic stroke.
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Neuroradiology Source Type: research
Conclusions In both CTP methods, the most prominent difference was found in dMTT. Visually, penumbra was better distinguished by SVD in proximal critical stenosis, whereas was better distinguished by SVD+ in distal critical stenosis. In cases having both ipsilateral critical proximal and distal stenoses, penumbra was noted in SVD but pseudohyperperfusion in SVD+. This finding showed that extraction of contrast delay in the SVD+ method might cause false results in cases of ipsilateral critical proximal and distal stenoses.
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Neuroradiology Source Type: research
Conclusions The optimized IVIM protocol proposed in the current study allows for measurements of cerebral hypoperfusion that might be of great interest for pathologies diagnosis such as ischemic stroke.
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Neuroradiology Source Type: research
CONCLUSIONS: The prevalence of low cerebral oximetry values underscores the importance of increasing the sensitivity of monitoring tools. Further evaluation is required to assess the value of this modality and the role of nurses in optimizing neurocognitive outcomes. PMID: 29284341 [PubMed - as supplied by publisher]
Source: Contemporary Nurse - Category: Nursing Tags: Contemp Nurse Source Type: research
Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys‐)functions. Bi‐directional feedback interactions between the heart and the brain are inherent in the pathophysiology of HF: (i) the impaired cardiac function affects cerebral structure and functional capacity, and (ii) neuronal signals impact on the cardiovascular continuum. These interactions contribute to the symptomatic presentation of HF patients and affect many co‐morbidities of HF. Moreover, neuro‐cardiac feedback signals significantly promote aggravation and further progression of HF ...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Position Paper Source Type: research
More News: Brain | Ischemic Stroke | Neurology | Perfusion | Stroke