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Influence of mobility restrictions on post ‐stroke pain
ConclusionsIn conclusion, the results suggest that restrictions in mobility and low vitality have an important role on the occurrence of post ‐stroke pain. Having post‐stroke pain could be due to not able to stand without losing balance and low vitality. Thus, rehabilitation professionals may consider the importance of these factors, especially mobility restrictions, in preventing post‐stroke pain.
Source: Brain and Behavior - March 2, 2021 Category: Neurology Authors: Pelin Atalan, Guna B ērziņa, Katharina S Sunnerhagen Tags: ORIGINAL RESEARCH Source Type: research

Suicide Following Stroke in the United States Veterans Health Administration Population
In the United States (US), suicide is a leading cause of death, and most of these suicides involve firearms, highlighting the importance of lethal means safety in suicide prevention.(1, 2) US Veterans experience a suicide rate 1.5 times higher than US civilian adults and are more likely to use firearms as the means of suicide.(3) Risk factors for suicide within this population include demographic factors such as sex, age, race, and level of education, as well as health factors such as smoking status, psychiatric conditions (e.g., posttraumatic stress disorder [PTSD], depression, bipolar and anxiety disorders, schizophrenia...
Source: Archives of Physical Medicine and Rehabilitation - March 31, 2021 Category: Rehabilitation Authors: Jordan M. Wyrwa, Tyler M. Shirel, Trisha A. Hostetter, Alexandra L. Schneider, Claire A. Hoffmire, Kelly A. Stearns-Yoder, Jeri E. Forster, Nathan E. Odom, Lisa A. Brenner Tags: Original Research Source Type: research

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD. Ethics Statement All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Advancing mediation analysis in occupational health research
In recent years, mediation analysis has become a popular means to identify and quantify pathways linking an exposure to an outcome, thereby elucidating how a particular exposure contributes to the occurrence of a specific outcome. When a mediator is a modifiable risk factor, this opens up new opportunities for interventions to block (part) of the exposure`s effect on the outcome. Recent examples in Scandinavian Journal of Work Environment Health have addressed the mediating effect of wellbeing on the association between type of office and job satisfaction (1) and examined whether workplace social capital contributes to the...
Source: Scandinavian Journal of Work, Environment and Health - January 17, 2020 Category: Occupational Health Tags: Editorial Source Type: research

Decreased physical health-related quality of life —a persisting state for older women with clinical vertebral fracture
ConclusionsClinical vertebral fracture was associated with lower self-rated physical HRQoL, for up to 18.9  years after time of fracture.
Source: Osteoporosis International - June 20, 2019 Category: Orthopaedics Source Type: research

A comparison of the effect of Swedish massage with and without chamomile oil on labor outcomes and maternal satisfaction of the childbirth process: a randomized controlled trial
ConclusionThe results of the study showed that using Swedish massage techniques with or without chamomile oil can improve labor outcomes. Swedish massage using chamomile oil was associated with better results compared to the same massage without using chamomile oil.Clinical trial code IRCT20200513047430N1.
Source: European Journal of Medical Research - November 25, 2022 Category: Research Source Type: research